Publications by authors named "Emily Rocha"

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Lessons from the Tim Greenamyre model.
Laurie H Sanders, Nancy Blechman, Sarah Berman, Erwan Bezard, Fabio Blandini, Emily Rocha

Neurobiol Dis· September 2025

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Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration.
Silas A Buck, Sophie A Rubin, Tenzin Kunkhyen, Christoph D Treiber, Xiangning Xue, Emily M Rocha

bioRxiv· July 2025

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Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson's model.
Maria Tsalenchuk, Kyle Farmer, Sandra Castro, Abigail Scheirer, Yuqian Ye, Emily M Rocha

NPJ Parkinsons Dis· July 2025

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A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress.
Leandro C Clementino, Andrew P Thomas, Emily M Rocha, Sabine Hilfiker

Cell Calcium· January 2025

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LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease.
Matthew T Keeney, Emily M Rocha, Eric K Hoffman, Kyle Farmer, Roberto Di Maio

Sci Transl Med· October 2024

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Leveraging Quality Improvement and Shared Learning to Improve Infant Well-Child Visit Rates in Texas.
Emily Stauffer Rocha, Susana Beatriz Peñate, Ryan D Van Ramshorst

Healthcare (Basel)· October 2024

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15-Lipoxygenase-Mediated Lipid Peroxidation Regulates LRRK2 Kinase Activity.
Matthew T Keeney, Eric K Hoffman, Julie Weir, Weston G Wagner, Emily M Rocha

bioRxiv· June 2024

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Recalibrating the Why and Whom of Animal Models in Parkinson Disease: A Clinician's Perspective.
Andrea Sturchio, Emily M Rocha, Marcelo A Kauffman, Luca Marsili, Abhimanyu Mahajan

Brain Sci· January 2024

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Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy.
Amber D Van Laar, Katherine R Webb, Matthew T Keeney, Victor S Van Laar, Alevtina Zharikov, Emily M Rocha

NPJ Parkinsons Dis· August 2023

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Aging, Parkinson's Disease, and Models: What Are the Challenges?
Emily Rocha, Manish Chamoli, Shankar J Chinta, Julie K Andersen, Ruby Wallis

Aging Biol· July 2023

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Disease mechanisms as subtypes: Lysosomal dysfunction in the endolysosomal Parkinson's disease subtype.
Adamantios Mamais, Rebecca Wallings, Emily M Rocha

Handb Clin Neurol· February 2023

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LRRK2 and idiopathic Parkinson's disease.
Emily M Rocha, Matthew T Keeney, Roberto Di Maio, Briana R De Miranda, J Timothy Greenamyre

Trends Neurosci· March 2022

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The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.
Briana R De Miranda, Sandra L Castro, Emily M Rocha, Christopher R Bodle, Katrina E Johnson

Neurobiol Dis· June 2021

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Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20.
Briana R De Miranda, Emily M Rocha, Sandra L Castro, J Timothy Greenamyre

NPJ Parkinsons Dis· December 2020

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LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease.
Emily M Rocha, Briana R De Miranda, Sandra Castro, Robert Drolet, Nathan G Hatcher

Neurobiol Dis· February 2020

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Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence.
Briana R De Miranda, Marco Fazzari, Emily M Rocha, Sandra Castro, J Timothy Greenamyre

Toxicol Sci· July 2019

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Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease.
Briana R De Miranda, Emily M Rocha, Qing Bai, Amina El Ayadi, David Hinkle

Neurobiol Dis· July 2018

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Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.
Penelope J Hallett, Mylene Huebecker, Oeystein R Brekk, Elizabeth B Moloney, Emily M Rocha

Neurobiol Aging· July 2018

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LRRK2 activation in idiopathic Parkinson's disease.
Roberto Di Maio, Eric K Hoffman, Emily M Rocha, Matthew T Keeney, Laurie H Sanders

Sci Transl Med· July 2018

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Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease.
Emily M Rocha, Briana De Miranda, Laurie H Sanders

Neurobiol Dis· January 2018

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A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Gaynor A Smith, Emily M Rocha, Thomas Rooney, Pascal Barneoud, Jesse R McLean

PLoS One· February 2016

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Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.
Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Eilish Brown

Neurobiol Dis· October 2015

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Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.
Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Anne-Renee Graham

Antioxid Redox Signal· August 2015

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Progressive decline of glucocerebrosidase in aging and Parkinson's disease.
Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Eilish Brown

Ann Clin Transl Neurol· April 2015

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ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.
Jesse R McLean, Gaynor A Smith, Emily M Rocha, Teresia M Osborn, Samar Dib

Exp Neurol· November 2014

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