Publications by authors named "Emilyn Alejandro"

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Placental mTOR signalling links mitochondrial dysfunction, nutrient transport and neonatal beta cell perturbations in mice.
Megan Beetch, Eunice Oribamise, Seokwon Jo, Briana Clifton, Sarah Larson, Emilyn U Alejandro

Diabetologia· December 2025

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Placental mitochondrial calcium uniporter modulates offspring susceptibility to metabolic dysfunction.
Seokwon Jo, Grace Chung, Yu-Jin Youn, Charlotte Hunt, Ava Hill, Emilyn U Alejandro

Mol Metab· October 2025

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Post translational modification regulation of transcription factors governing pancreatic β-cell identity and functional mass.
Alicia Wong, Emilyn U Alejandro

Front Endocrinol (Lausanne)· May 2025

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Improved glucose handling in female rat offspring of a hypertensive pregnancy with intrauterine growth restriction.
Melissa A Cedars, Kate M Root, Brian Akhaphong, Megan Beetch, Abigail E Miles, Emilyn U Alejandro

Physiol Rep· February 2025

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Loss of O-GlcNAcylation modulates mTORC1 and autophagy in β cells, driving diabetes 2 progression.
Seokwon Jo, Nicholas Esch, Anh Nguyen, Alicia Wong, Ramkumar Mohan, Emilyn U Alejandro

JCI Insight· December 2024

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Sweet Spot Regulation of Maternal Metabolic Health and Nutrition on β-Cell Mass in the Offspring.
Grace Chung, Alicia Wong, Tracy Her, Emilyn U Alejandro

Adv Anat Embryol Cell Biol· September 2024

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Circadian Disruption across Lifespan Impairs Glucose Homeostasis and Insulin Sensitivity in Adult Mice.
Tracy K Her, Jin Li, Hao Lin, Dong Liu, Kate M Root, Emilyn U Alejandro

Metabolites· February 2024

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RISING STARS: Mechanistic insights into maternal-fetal cross talk and islet beta-cell development.
Seokwon Jo, Emilyn U Alejandro

J Endocrinol· December 2023

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Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring.
Megan Beetch, Brian Akhaphong, Alicia Wong, Briana Clifton, Seokwon Jo, Emilyn U Alejandro

J Mol Endocrinol· November 2023

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Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis.
Bhavani S Sahu, Maria Razzoli, Seth McGonigle, Jean Pierre Pallais, Megin E Nguyen, Emilyn Alejandro

Mol Metab· October 2023

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A computational bridge between traction force microscopy and tissue contraction.
Shannon M Flanary, Seokwon Jo, Rohit Ravichandran, Emilyn U Alejandro, Victor H Barocas

J Appl Phys· August 2023

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Sex Differences in Pancreatic β-Cell Physiology and Glucose Homeostasis in C57BL/6J Mice.
Seokwon Jo, Megan Beetch, Eric Gustafson, Alicia Wong, Eunice Oribamise, Emilyn U Alejandro

J Endocr Soc· August 2023

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Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner.
Sereen K Nashif, Renee M Mahr, Snehalata Jena, Seokwon Jo, Alisa B Nelson, Emilyn U Alejandro

Front Cell Dev Biol· May 2023

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Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis.
Bhavani S Sahu, Maria Razzoli, Seth McGonigle, Jean Pierre Pallais, Megin E Nguyen, Emilyn Alejandro

bioRxiv· March 2023

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Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion.
Alicia Wong, Samantha Pritchard, Mackenzie Moore, Brian Akhaphong, Nandini Avula, Emilyn U Alejandro

J Biol Chem· February 2023

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Metformin impairs trophoblast metabolism and differentiation in dose dependent manner.
Sereen K Nashif, Renee M Mahr, Snehalata Jena, Seokwon Jo, Alisa B Nelson, Emilyn U Alejandro

bioRxiv· February 2023

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Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies.
Kate M Root, Brian Akhaphong, Melissa A Cedars, Alexa M Molin, Margaretta E Huchthausen, Emilyn U Alejandro

Diabetes· December 2022

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Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass.
Alicia Wong, Brian Akhaphong, Daniel Baumann, Emilyn U Alejandro

Biomedicines· December 2022

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Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis .
Seokwon Jo, Samantha Pritchard, Alicia Wong, Nandini Avula, Ahmad Essawy, Emilyn U Alejandro

Front Endocrinol (Lausanne)· November 2022

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Editorial: Research Topic for Frontiers in Endocrinology (Obesity): Fetal Origin of Obesity and Diabetes.
Joanna H Sliwowska, Emilyn U Alejandro, Adam Gesing

Front Endocrinol (Lausanne)· July 2022

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Maternal High-Fat Diet During Pre-Conception and Gestation Predisposes Adult Female Offspring to Metabolic Dysfunction in Mice.
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Emilyn U Alejandro

Front Endocrinol (Lausanne)· March 2022

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Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival.
Seokwon Jo, Emilyn U Alejandro

Diabetes· March 2022

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Placental Insulin Receptor Transiently Regulates Glucose Homeostasis in the Adult Mouse Offspring of Multiparous Dams.
Grace Chung, Ramkumar Mohan, Megan Beetch, Seokwon Jo, Emilyn Uy Alejandro

Biomedicines· March 2022

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Reduction in O-GlcNAcylation Mitigates the Severity of Inflammatory Response in Cerulein-Induced Acute Pancreatitis in a Mouse Model.
Mackenzie Moore, Nandini Avula, Alicia Wong, Megan Beetch, Seokwon Jo, Emilyn U Alejandro

Biology (Basel)· February 2022

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Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring.
Megan Beetch, Emilyn U Alejandro

Children (Basel)· October 2021

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