Publications by authors named "Emma Heart"

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BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt.
Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Emma A Heart

Environ Toxicol Pharmacol· December 2017

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Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways.
Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Angela L Slitt, Emma A Heart

PLoS One· October 2017

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NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) and cytochrome P450 oxidoreductase (CYP450OR) differentially regulate menadione-mediated alterations in redox status, survival and metabolism in pancreatic β-cells.
Joshua P Gray, Shpetim Karandrea, Delaine Zayasbazan Burgos, Anil A Jaiswal, Emma A Heart

Toxicol Lett· November 2016

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Mechanisms of Doxorubicin Toxicity in Pancreatic β-Cells.
Emma A Heart, Shpetim Karandrea, Xiaomei Liang, Maren E Balke, Patrick A Beringer

Toxicol Sci· August 2016

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Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA.
Joshua P Gray, Delaine Zayasbazan Burgos, Tao Yuan, Navindra Seeram, Rebecca Rebar, Emma A Heart

Am J Physiol Endocrinol Metab· March 2016

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NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells.
Joshua P Gray, Kambiz N Alavian, Elizabeth A Jonas, Emma A Heart

Am J Physiol Endocrinol Metab· July 2012

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The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion.
Emma Heart, Meridith Palo, Trayce Womack, Peter J S Smith, Joshua P Gray

Toxicol Appl Pharmacol· January 2012

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Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1.
Joshua P Gray, Timothy Eisen, Gary W Cline, Peter J S Smith, Emma Heart

Am J Physiol Endocrinol Metab· July 2011

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Usurping the mitochondrial supremacy: extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion.
Joshua P Gray, Emma Heart

Toxicol Mech Methods· May 2010

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Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.
Marie-Line Peyot, Joshua P Gray, Julien Lamontagne, Peter J S Smith, George G Holz, Emma Heart

PLoS One· July 2009

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Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.
Emma Heart, Gary W Cline, Leon P Collis, Rebecca L Pongratz, Joshua P Gray

Am J Physiol Endocrinol Metab· June 2009

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Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach".
George G Holz, Emma Heart, Colin A Leech

Am J Physiol Cell Physiol· January 2008

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beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.
Jakob D Wikstrom, Shana M Katzman, Hibo Mohamed, Gilad Twig, Solomon A Graf, Emma Heart

Diabetes· October 2007

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Rhythm of the beta-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior.
Emma Heart, Peter J S Smith

Am J Physiol Endocrinol Metab· May 2007

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Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.
Emma Heart, Gordon C Yaney, Richard F Corkey, Vera Schultz, Esthere Luc

Biochem J· April 2007

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Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells.
Emma Heart, Richard F Corkey, Jacob D Wikstrom, Orian S Shirihai, Barbara E Corkey

Am J Physiol Endocrinol Metab· January 2006

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Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes.
Emma Heart, Chin K Sung

J Cell Biochem· March 2003

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Glucose transport by osmotic shock and vanadate is impaired by glucosamine.
Emma Heart, Chin K Sung

Biochem Biophys Res Commun· March 2002

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