Publications by authors named "Emma M Lessieur"

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Lysyl Oxidase Promotes Actin-Dependent Neutrophil Activation and Cytotoxicity Toward Retinal Endothelial Cells in Diabetes.
Mahesh Agarwal, Sathishkumar Chandrakumar, Irene Santiago Tierno, Emma M Lessieur, Zak R Bollinger

Diabetes· January 2026

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Lysyl oxidase promotes actin-dependent neutrophil activation and cytotoxicity in diabetes: Implications for diabetic retinopathy.
Mahesh Agarwal, Sathishkumar Chandrakumar, Irene Santiago Tierno, Emma M Lessieur, Zak R Bollinger

bioRxiv· May 2025

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Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature.
Emma M Lessieur, Timothy S Kern

J Vis Exp· January 2025

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Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes.
Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Emma M Lessieur, Yunpeng Du

Diabetes· February 2024

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Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.
Jennings C Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Emma M Lessieur

Proc Natl Acad Sci U S A· May 2023

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CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice.
Aicha Saadane, Alexander A Veenstra, Martin S Minns, Jie Tang, Yunpeng Du, Emma M Lessieur

Diabetologia· March 2023

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ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes.
Emma M Lessieur, Haitao Liu, Aicha Saadane, Yunpeng Du, Jianying Kiser

Diabetologia· October 2022

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Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α-antitrypsin-derived peptide motif.
Michelle A Cruz, Dillon Bohinc, Elizabeth A Andraska, Jurgis Alvikas, Shruti Raghunathan, Emma M Lessieur

Nat Nanotechnol· September 2022

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Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy.
Aicha Saadane, Yunpeng Du, Wallace B Thoreson, Masaru Miyagi, Emma M Lessieur

Am J Pathol· October 2021

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Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy.
Emma M Lessieur, Haitao Liu, Aicha Saadane, Yunpeng Du, Jie Tang

Invest Ophthalmol Vis Sci· October 2021

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Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy.
Aicha Saadane, Emma M Lessieur, Yunpeng Du, Haitao Liu, Timothy S Kern

PLoS One· November 2020

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Ciliary genes arl13b, ahi1 and cc2d2a differentially modify expression of visual acuity phenotypes but do not enhance retinal degeneration due to mutation of cep290 in zebrafish.
Emma M Lessieur, Ping Song, Gabrielle C Nivar, Ellen M Piccillo, Joseph Fogerty

PLoS One· December 2019

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Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy.
Haitao Liu, Emma M Lessieur, Aicha Saadane, Sarah I Lindstrom, Patricia R Taylor

Diabetologia· December 2019

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The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival.
Emma M Lessieur, Joseph Fogerty, Robert J Gaivin, Ping Song, Brian D Perkins

Invest Ophthalmol Vis Sci· January 2017

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The adult zebrafish retina: In vivo optical sectioning with Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography.
Brent A Bell, Alex Yuan, Rose M Dicicco, Joseph Fogerty, Emma M Lessieur

Exp Eye Res· December 2016

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