Publications by authors named "Emmanuel Deau"

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DYRK1A inhibition restores pancreatic functions and improves glucose metabolism in a preclinical model of type 2 diabetes.
Romane Bertrand, Stefania Tolu, Delphine Picot, Cécile Tourrel-Cuzin, Ayoub Ouahab, Emmanuel Deau

Mol Metab· November 2025

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Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury.
Bryce C Murillo, Alexander Young, Kaitlyn L Wintruba, Alexander J Eichert, Klara Siejda, Emmanuel Deau

bioRxiv· August 2025

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Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.
Shannon L Carey-Smith, Maryam H Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Emmanuel Deau

Haematologica· July 2024

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Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.
Eva Lana-Elola, Rifdat Aoidi, Miriam Llorian, Dorota Gibbins, Callan Buechsenschuetz, Emmanuel Deau

Sci Transl Med· January 2024

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Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate.
Mattias F Lindberg, Emmanuel Deau, Frédéric Miege, Marie Greverie, Didier Roche

J Med Chem· December 2023

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Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.
Emmanuel Deau, Mattias F Lindberg, Frédéric Miege, Didier Roche, Nicolas George

J Med Chem· August 2023

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Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases.
Mattias F Lindberg, Emmanuel Deau, Jonas Arfwedson, Nicolas George, Pascal George

J Med Chem· March 2023

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Serodolin, a β-arrestin-biased ligand of 5-HT receptor, attenuates pain-related behaviors.
Chayma El Khamlichi, Flora Reverchon, Nadège Hervouet-Coste, Elodie Robin, Nicolas Chopin, Emmanuel Deau

Proc Natl Acad Sci U S A· May 2022

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Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
Tania Tahtouh, Emilie Durieu, Benoît Villiers, Céline Bruyère, Thu Lan Nguyen, Emmanuel Deau

J Med Chem· January 2022

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Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives.
Emmanuel Deau, Alexandra Le Foll, Clémence Fouache, Emilie Corrot, Laetitia Bailly

Chem Commun (Camb)· August 2021

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Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain.
Emmanuel Deau, Elodie Robin, Raluca Voinea, Nathalie Percina, Grzegorz Satała

J Med Chem· October 2015

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Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors.
Yvonnick Loidreau, Emmanuel Deau, Pascal Marchand, Marie-Renée Nourrisson, Cédric Logé

Eur J Med Chem· March 2015

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Microwave-assisted kinetic resolution of homochiral (Z)-cyclooct-5-ene-1,2-diol and (Z)-2-acetoxycyclooct-4-enyl acetate using lipases.
Hervé Rouillard, Emmanuel Deau, Lisianne Domon, Jean-René Chérouvrier, Marianne Graber

Molecules· July 2014

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Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.
Emmanuel Deau, Yvonnick Loidreau, Pascal Marchand, Marie-Renée Nourrisson, Nadège Loaëc

Bioorg Med Chem Lett· December 2013

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