Publications by authors named "Enoch Kumar Perimal"

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Elucidating zerumbone's low-efficacy agonism at the μ-opioid receptor via molecular dynamics simulation and Markov state modeling.
Wan Mardhiyana Wan Ayub, Nurul Amirah Marjohan, Mohamed Haneif Khalid, Enoch Kumar Perimal, Muhamad Arif Mohamad Jamali

J Comput Aided Mol Des· October 2025

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Cardio- and neuroprotective effects by pretreatment of dietary moringin from seeds and α-CD/moringin formulation in a rat model of isoproterenol-induced myocardial infarction.
Ahmad Faizal Abdull Razis, Ramla Muhammad Kamal, Gina Rosalinda De Nicola, Sabine Montaut, Enoch Kumar Perimal

J Nutr Sci· September 2025

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Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases.
Ramla Muhammad Kamal, Ahmad Faizal Abdull Razis, Nurul Syafuhah Mohd Sukri, Enoch Kumar Perimal, Hafandi Ahmad

Molecules· January 2022

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Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice.
Hui Ming Ong, Ahmad Farhan Ahmad Azmi, Sze Wei Leong, Faridah Abas, Enoch Kumar Perimal

Sci Rep· December 2021

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The Involvement of l-Arginine-Nitric Oxide-cGMP-ATP-Sensitive K Channel Pathway in Antinociception of BBHC, a Novel Diarylpentanoid Analogue, in Mice Model.
Hui Ming Ong, Ahmad Farhan Ahmad Azmi, Sze Wei Leong, Faridah Abas, Enoch Kumar Perimal

Molecules· December 2021

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Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models.
Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Hanis Zakaria, Enoch Kumar Perimal

Molecules· June 2021

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Cardamonin Modulates Neuropathic Pain through the Possible Involvement of Serotonergic 5-HT1A Receptor Pathway in CCI-Induced Neuropathic Pain Mice Model.
Nur Khalisah Kaswan, Noor Aishah Binti Mohammed Izham, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perimal

Molecules· June 2021

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Possible Participation of Ionotropic Glutamate Receptors and l-Arginine-Nitric Oxide-Cyclic Guanosine Monophosphate-ATP-Sensitive K Channel Pathway in the Antinociceptive Activity of Cardamonin in Acute Pain Animal Models.
Chung Pui Ping, Muhammad Nadeem Akhtar, Daud Ahmad Israf, Enoch Kumar Perimal, Mohd Roslan Sulaiman

Molecules· November 2020

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Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain.
Banulata Gopalsamy, Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, Enoch Kumar Perimal

Molecules· August 2020

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Zerumbone Modulates α-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain and LPS-Induced SH-SY5Y Neuroblastoma Models.
Jasmine Siew Min Chia, Noor Aishah Mohammed Izham, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, Sanam Mustafa, Enoch Kumar Perimal

Front Pharmacol· March 2020

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Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats.
Sahba Jafarian, King-Hwa Ling, Zurina Hassan, Lua Perimal-Lewis, Mohd Roslan Sulaiman, Enoch Kumar Perimal

Alzheimers Dement (N Y)· October 2019

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Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice.
Banulata Gopalsamy, Yogesvari Sambasevam, Nurul Atiqah Zulazmi, Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Enoch Kumar Perimal

Neurochem Res· September 2019

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Morning boost on individuals' psychophysiological wellbeing indicators with supportive, dynamic lighting in windowless open-plan workplace in Malaysia.
RatnaKala Sithravel, Rahinah Ibrahim, Munn Sann Lye, Enoch Kumar Perimal, Normala Ibrahim

PLoS One· April 2019

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Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV₁, Glutamate, and Opioid Receptors.
Chung Pui Ping, Tengku Azam Shah Tengku Mohamad, Muhammad Nadeem Akhtar, Enoch Kumar Perimal, Ahmad Akira

Molecules· September 2018

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Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain.
Banulata Gopalsamy, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perimal

J Pain Res· November 2017

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Zerumbone Alleviates Neuropathic Pain through the Involvement of l-Arginine-Nitric Oxide-cGMP-K⁺ ATP Channel Pathways in Chronic Constriction Injury in Mice Model.
Nurul Atiqah Zulazmi, Banulata Gopalsamy, Jasmine Chia Siew Min, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, Enoch Kumar Perimal

Molecules· March 2017

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Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system.
Yogesvari Sambasevam, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, B Hemabarathy Bharatham, Enoch Kumar Perimal

Eur J Pharmacol· February 2017

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Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats.
Fui-Ling Voon, Mohd Roslan Sulaiman, Muhammad Nadeem Akhtar, Mohamad Fauzi Idris, Ahmad Akira, Enoch Kumar Perimal

Eur J Pharmacol· January 2017

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Zerumbone alleviates chronic constriction injury-induced allodynia and hyperalgesia through serotonin 5-HT receptors.
Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Azam Shah Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perimal

Biomed Pharmacother· October 2016

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Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception.
Nur Izzati Ismail, Lee Ming-Tatt, Nordin Lajis, Muhammad Nadeem Akhtar, Ahmad Akira, Enoch Kumar Perimal

Molecules· August 2016

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Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain.
Nurul Atiqah Zulazmi, Banulata Gopalsamy, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, B Hemabarathy Bharatham, Enoch Kumar Perimal

Fitoterapia· September 2015

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Development and characterization of novel porous 3D alginate-cockle shell powder nanobiocomposite bone scaffold.
B Hemabarathy Bharatham, Md Zuki Abu Bakar, Enoch Kumar Perimal, Loqman Mohamed Yusof, Muhajir Hamid

Biomed Res Int· March 2015

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Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ-opioid receptor and KATP.
Lee Ming-Tatt, Shaik Ibrahim Khalivulla, Muhammad Nadeem Akhtar, Nordin Lajis, Enoch Kumar Perimal

Pharmacol Biochem Behav· December 2013

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Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway.
Mohd Nasier Kamaldin, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Nordin Lajis, Enoch Kumar Perimal

Molecules· April 2013

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Antinociceptive activity of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on nociception-induced models in mice.
Lee Ming-Tatt, Shaik Ibrahim Khalivulla, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Enoch Kumar Perimal

Basic Clin Pharmacol Toxicol· March 2012

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