Publications by authors named "Erding Hu"

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Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression.
Amin Abedini, Jonathan Levinsohn, Konstantin A Klötzer, Bernhard Dumoulin, Ziyuan Ma, Erding Hu, Christopher A Hunter

Nat Genet· August 2024

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Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury.
Chia-Yi Kuan, Hong-Ru Chen, Ning Gao, Yi-Min Kuo, Ching-Wen Chen, Erding Hu

Neurobiol Dis· January 2021

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Carcinogenicity Assessment of Daprodustat (GSK1278863), a Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor.
David F Adams, Mark S Watkins, Luc Durette, Josée Laliberté, Félix Goulet, Erding Hu

Toxicol Pathol· February 2020

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In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice.
Stephen C Lenhard, Allen McAlexander, Anthony Virtue, William Fieles, Tina Skedzielewski, Erding Hu

J Pharmacol Exp Ther· September 2019

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Curvature facilitates podocyte culture in a biomimetic platform.
Anastasia Korolj, Carol Laschinger, Chris James, Erding Hu, Claire Velikonja

Lab Chip· October 2018

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Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes.
Sean P Sheehy, Anna Grosberg, Pu Qin, David J Behm, John P Ferrier, Erding Hu

Exp Biol Med (Maywood)· November 2017

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The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits.
Jin Zhou, Jie Li, Daniel M Rosenbaum, Jian Zhuang, Carrie Poon, Erding Hu

PLoS One· October 2017

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Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress.
Pu Qin, Pelin Arabacilar, Roberta E Bernard, Weike Bao, Alan R Olzinski, Ashley M Hughes, Erding Hu

J Am Heart Assoc· May 2017

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Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Han Dai, April W Case, Thomas V Riera, Thomas Considine, Jessica E Lee, Huizhen Zhao, Minghui Wang, Erding Hu

Nat Commun· July 2015

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Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease.
Eric Olson, Laura Demopoulos, Thomas F Haws, Erding Hu, Zixing Fang

Vasc Med· December 2014

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Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells.
Mara Fornaro, Aaron C Hinken, Saul Needle, Erding Hu, Anne-Ulrike Trendelenburg, Arthur D Brace

Am J Physiol Endocrinol Metab· January 2014

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Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.
Christine Y Ivashchenko, Gordon C Pipes, Irina M Lozinskaya, Zuojun Lin, Xu Xiaoping, Erding Hu

Am J Physiol Heart Circ Physiol· September 2013

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Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature.
Huansheng Xu, B Alexander Yi, Hao Wu, Christoph Bock, Hongcang Gu, Erding Hu

Cell Res· January 2012

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Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population.
Anne M Curtis, Lifeng Zhang, Elizabeth Medenilla, Ming Gui, Patrick F Wilkinson, Erding Hu

Cytometry B Clin Cytom· September 2010

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Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.
Weike Bao, Pu Qin, Saul Needle, Connie L Erickson-Miller, Kevin J Duffy, Shufang Zhao, Erding Hu

J Cardiovasc Pharmacol· August 2010

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Heme-oxygenase induction inhibits arteriolar thrombosis in vivo: effect of the non-substrate inducer cobalt protoporphyrin.
Douglas G Johns, Dorothy Zelent, Zhaohui Ao, Benjamin T Bradley, Alexandra Cooke, Erding Hu

Eur J Pharmacol· March 2009

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Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
Clark A Sehon, Gren Z Wang, Andrew Q Viet, Krista B Goodman, Sarah E Dowdell, Erding Hu

J Med Chem· November 2008

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Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
Chris Doe, Ross Bentley, David J Behm, Robert Lafferty, Robert Stavenger, Erding Hu

J Pharmacol Exp Ther· January 2007

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Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
Robert A Stavenger, Haifeng Cui, Sarah E Dowdell, Robert G Franz, Dimitri E Gaitanopoulos, Daohua Zhang, Erding Hu

J Med Chem· January 2007

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Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
Krista B Goodman, Haifeng Cui, Sarah E Dowdell, Dimitri E Gaitanopoulos, Robert L Ivy, Erding Hu

J Med Chem· January 2007

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Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases.
Erding Hu

Recent Pat Cardiovasc Drug Discov· November 2006

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Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.
Sanjay S Khandekar, Tracey Yi, Ed Dul, Lois L Wright, Susan Chen, Erding Hu

Protein Pept Lett· July 2006

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Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges.
Erding Hu, Dennis Lee

Expert Opin Ther Targets· August 2005

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Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury.
Weike Bao, Erding Hu, Ling Tao, Rogely Boyce, Rosanna Mirabile, Douglas T Thudium

Cardiovasc Res· February 2004

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Rho kinase inhibitors as potential therapeutic agents for cardiovascular diseases.
Erding Hu, Dennis Lee

Curr Opin Investig Drugs· September 2003

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