Publications by authors named "Eric LeFebvre"

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Phase II INTEGRIS-PSC trial of bexotegrast, an αβ/αβ integrin inhibitor, in primary sclerosing cholangitis.
Gideon M Hirschfield, Kris V Kowdley, Palak J Trivedi, Bertus Eksteen, Bilal Hameed, Éric A Lefebvre

J Hepatol· January 2026

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Cosmic Ray-induced Radiation Exposure among Summer and Overwintering Expeditioners in the High-altitude Antarctic Environment.
Guillaume Hubert, Eric Lefebvre

Radiat Res· December 2025

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Dual αβ and αβ Inhibition over 12 Weeks Reduces Active Type I Collagen Deposition in Individuals with Idiopathic Pulmonary Fibrosis: A Phase 2, Double-Blind, Placebo-controlled Clinical Trial.
Sydney B Montesi, Gregory P Cosgrove, Scott M Turner, Iris Y Zhou, Nikos Efthimiou, Éric A Lefebvre

Am J Respir Crit Care Med· July 2025

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Bexotegrast Shows Dose-Dependent Integrin αβ Receptor Occupancy in Lungs of Participants with Idiopathic Pulmonary Fibrosis: A Phase 2, Open-Label Clinical Trial.
Joshua J Mooney, Susan Jacobs, Éric A Lefebvre, Gregory P Cosgrove, Annie Clark

Ann Am Thorac Soc· March 2025

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Bexotegrast in people with idiopathic pulmonary fibrosis (IPF): a plain language summary of publication of the INTEGRIS-IPF study.
Lisa Lancaster, Vincent Cottin, Murali Ramaswamy, Wim A Wuyts, R Gisli Jenkins, Éric A Lefebvre

Ther Adv Respir Dis· November 2024

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Bexotegrast in Patients with Idiopathic Pulmonary Fibrosis: The INTEGRIS-IPF Clinical Trial.
Lisa Lancaster, Vincent Cottin, Murali Ramaswamy, Wim A Wuyts, R Gisli Jenkins, Éric A Lefebvre

Am J Respir Crit Care Med· August 2024

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Comparison of ADAPT, FIB-4 and APRI as non-invasive predictors of liver fibrosis and NASH within the CENTAUR screening population.
Mette Juul Nielsen, Diana Julie Leeming, Zachary Goodman, Scott Friedman, Peder Frederiksen, Eric Lefebvre

J Hepatol· December 2021

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Dual inhibition of αβ and αβ reduces fibrogenesis in lung tissue explants from patients with IPF.
Martin L Decaris, Johanna R Schaub, Chun Chen, Jacob Cha, Gail G Lee, Eric A Lefebvre

Respir Res· October 2021

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Antarctic surface temperature and elevation during the Last Glacial Maximum.
Christo Buizert, T J Fudge, William H G Roberts, Eric J Steig, Sam Sherriff-Tadano, Eric Lefebvre

Science· June 2021

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Efficacy and Safety of Cenicriviroc in Patients With Primary Sclerosing Cholangitis: PERSEUS Study.
Bertus Eksteen, Christopher L Bowlus, Aldo J Montano-Loza, Eric Lefebvre, Laurent Fischer

Hepatol Commun· March 2021

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Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.
Patrick P Lowe, Caroline Morel, Aditya Ambade, Arvin Iracheta-Vellve, Erica Kwiatkowski, Eric Lefebvre

J Neuroinflammation· October 2020

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Low Cost and Compact FMCW 24 GHz Radar Applications for Snowpack and Ice Thickness Measurements.
Patrick Pomerleau, Alain Royer, Alexandre Langlois, Patrick Cliche, Bruno Courtemanche, Éric Lefebvre

Sensors (Basel)· July 2020

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APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz.
Daniela A Covino, Cristina Purificato, Laura Catapano, Clementina M Galluzzo, Maria Cristina Gauzzi, Eric Lefebvre

Front Immunol· September 2019

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The Critical Role of Chemokine (C-C Motif) Receptor 2-Positive Monocytes in Autoimmune Cholangitis.
Debby Reuveni, Yael Gore, Patrick S C Leung, Yael Lichter, Itay Moshkovits, Eric Lefebvre

Front Immunol· September 2019

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Cerebrospinal fluid exposure of cenicriviroc in HIV-positive individuals with cognitive impairment.
Jasmini Alagaratnam, Sujan Dilly-Penchala, Elizabeth Challenger, Laura Else, Ken Legg, Eric Lefebvre

Br J Clin Pharmacol· May 2019

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Rates of and Factors Associated With Placebo Response in Trials of Pharmacotherapies for Nonalcoholic Steatohepatitis: Systematic Review and Meta-analysis.
Ma Ai Thanda Han, Osama Altayar, Shadi Hamdeh, Varun Takyar, Yaron Rotman, Eric Lefebvre

Clin Gastroenterol Hepatol· March 2019

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Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.
Aditya Ambade, Patrick Lowe, Karen Kodys, Donna Catalano, Benedek Gyongyosi, Eric Lefebvre

Hepatology· March 2019

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Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression.
Michelle L D'Antoni, Brooks I Mitchell, Sara McCurdy, Mary Margaret Byron, Debra Ogata-Arakaki, Eric Lefebvre

J Leukoc Biol· December 2018

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Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism.
Michelle L DʼAntoni, Robert H Paul, Brooks I Mitchell, Lindsay Kohorn, Laurent Fischer, Eric Lefebvre

J Acquir Immune Defic Syndr· September 2018

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A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.
Scott L Friedman, Vlad Ratziu, Stephen A Harrison, Manal F Abdelmalek, Guruprasad P Aithal, Eric Lefebvre

Hepatology· May 2018

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Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet-induced mouse model of nonalcoholic steatohepatitis.
Annie J Kruger, Bryan C Fuchs, Ricard Masia, Jacinta A Holmes, Shadi Salloum, Eric Lefebvre

Hepatol Commun· May 2018

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Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis.
Oliver Krenkel, Tobias Puengel, Olivier Govaere, Ali T Abdallah, Jana C Mossanen, Eric Lefebvre

Hepatology· April 2018

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Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury.
Tobias Puengel, Oliver Krenkel, Marlene Kohlhepp, Eric Lefebvre, Tom Luedde

PLoS One· October 2017

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Availability of Advance Care Planning Documentation for Older Emergency Department Patients: A Cross-Sectional Study.
Timothy F Platts-Mills, Natalie L Richmond, Eric M LeFebvre, Sowmya A Mangipudi, Allison G Hollowell

J Palliat Med· January 2017

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Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury.
Jana C Mossanen, Oliver Krenkel, Can Ergen, Olivier Govaere, Anke Liepelt, Eric Lefebvre

Hepatology· November 2016

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