Publications by authors named "Eric Lightcap"

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In Vivo Tumor Growth Control by General Control Nonderepressible 2-Targeting Agents Results from Kinase Activation.
Feven Tameire, Paulina Wojnarowicz, Crissy Dudgeon, Kathryn T Bieging-Rolett, Sho Fujisawa, Eric S Lightcap

Mol Cancer Ther· September 2025

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In Vivo Tumor Growth Control by General Control Nonderepressible 2 Targeting Agents Results from Kinase Activation.
Feven Tameire, Paulina Wojnarowicz, Crissy Dudgeon, Kathryn T Bieging-Rolett, Sho Fujisawa, Eric S Lightcap

Mol Cancer Ther· August 2025

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Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator.
Christopher G Thomson, Thomas D Aicher, Weiwei Cheng, Hongwen Du, Crissy Dudgeon, Eric Lightcap

J Med Chem· April 2024

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PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.
Michael E Stokes, Veronica Calvo, Sho Fujisawa, Crissy Dudgeon, Sharon Huang, Eric S Lightcap

Clin Cancer Res· December 2023

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CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade.
Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Ryo Kamata, Gaku Yamamoto, Eric Lightcap

Nat Commun· November 2023

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A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models.
Eric S Lightcap, Pengfei Yu, Stephen Grossman, Keli Song, Mithun Khattar

Sci Transl Med· September 2021

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Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD.
Hong Liu, Suryasarathi Dasgupta, Yu Fu, Brandi Bailey, Christian Roy, Eric Lightcap

BMC Immunol· November 2019

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.
Xingyue He, Jessica Riceberg, Teresa Soucy, Erik Koenig, James Minissale, Eric S Lightcap

Nat Chem Biol· November 2017

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Acoustic Liquid Handling for Rapid siRNA Transfection Optimization.
Andrew S Xiao, Eric S Lightcap, David C Bouck

J Biomol Screen· September 2015

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Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.
Khristofer Garcia, Jonathan L Blank, David C Bouck, Xiaozhen J Liu, Darshan S Sappal, Eric S Lightcap

Mol Cancer Ther· June 2014

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Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.
Jonathan L Blank, Xiaozhen J Liu, Katherine Cosmopoulos, David C Bouck, Khristofer Garcia, Eric S Lightcap

Cancer Res· January 2013

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Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.
Devin T Worster, Tobias Schmelzle, Nicole L Solimini, Eric S Lightcap, Bjorn Millard

Sci Signal· March 2012

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Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.
Hua Liao, Xiaozhen J Liu, Jonathan L Blank, David C Bouck, Hugues Bernard, Eric S Lightcap

Mol Cell Proteomics· November 2011

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Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib.
Siquan Chen, Jonathan L Blank, Theodore Peters, Xiaozhen J Liu, David M Rappoli, Eric S Lightcap

Cancer Res· June 2010

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MYC regulation of a "poor-prognosis" metastatic cancer cell state.
Anita Wolfer, Ben S Wittner, Daniel Irimia, Richard J Flavin, Mathieu Lupien, Eric S Lightcap

Proc Natl Acad Sci U S A· February 2010

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Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.
Tobias Schmelzle, Arnaud A Mailleux, Michael Overholtzer, Jason S Carroll, Nicole L Solimini, Eric S Lightcap

Proc Natl Acad Sci U S A· March 2007

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Edge-count probabilities for the identification of local protein communities and their organization.
Victor Farutin, Keith Robison, Eric Lightcap, Vlado Dancik, Alan Ruttenberg

Proteins· March 2006

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Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver.
Dhirendra Nandi, Eric S Lightcap, Yumee Kim Koo, Xingliang Lu, Jean Quancard

Int J Biochem Cell Biol· July 2003

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Assays for proteasome inhibition.
Peter J Elliott, Teresa A Soucy, Christine S Pien, Julian Adams, Eric S Lightcap

Methods Mol Med· June 2003

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Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341.
James A Fleming, Eric S Lightcap, Seth Sadis, Vala Thoroddsen, Christine E Bulawa

Proc Natl Acad Sci U S A· February 2002

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