Publications by authors named "Eric Meffre"

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CTLA-4 blockade shifts the B cell repertoire toward autoimmunity.
Elif Çakan, Meng Wang, Yile Dai, Adrien Mirouse, Clarence Rachel Villanueva-Pachas, Eric Meffre

J Clin Invest· November 2025

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Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus.
Shady Younis, Salvinaz I Moutusy, Sajede Rasouli, Shaghayegh Jahanbani, Mahesh Pandit, Eric Meffre

Sci Transl Med· November 2025

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Senescent Activated Naive B Cells Promote Anti-Citrullinated Antigen T Cell Responses and the Transition to Clinical Rheumatoid Arthritis.
Xiaohao Wu, Mengrui Zhang, Jae-Seung Moon, Eun Kyung Song, Joshua C Abrams, Eric Meffre

bioRxiv· October 2025

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Nuclear-penetrating scleroderma autoantibody inhibits topoisomerase 1 cleavage complex formation.
Christopher K May, Philip W Noble, Erica L Herzog, Eric Meffre, James E Hansen

Biochem Biophys Res Commun· August 2024

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FOXP3 deficiency, from the mechanisms of the disease to curative strategies.
Simon Borna, Eric Meffre, Rosa Bacchetta

Immunol Rev· March 2024

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Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation?
Dana Ghergus, Mickaël Martin, Anne-Marie Knapp, Fabien Delmotte, Aurélie Joublin-Delavat, Eric Meffre

Am J Hematol· January 2024

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TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance.
Elif Çakan, Marie Dominique Ah Kioon, Yolanda Garcia-Carmona, Salomé Glauzy, David Oliver, Eric Meffre

J Exp Med· December 2023

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Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with mutations.
Šimon Borna, Esmond Lee, Jason Nideffer, Akshaya Ramachandran, Bing Wang, Eric Meffre

Sci Transl Med· December 2023

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Germline genetic variants are associated with development of insulin-dependent diabetes in cancer patients treated with immune checkpoint inhibitors.
Jasmine I Caulfield, Lilach Aizenbud, Ana Luisa Perdigoto, Eric Meffre, Lucia Jilaveanu

J Immunother Cancer· March 2023

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Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.
Adriana A de Jesus, Guibin Chen, Dan Yang, Tomas Brdicka, Natasha M Ruth, Eric Meffre

Nat Commun· March 2023

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Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms.
Adeleh Taghi Khani, Anil Kumar, Ashly Sanchez Ortiz, Kelly C Radecki, Soraya Aramburo, Eric Meffre

Commun Biol· March 2023

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Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling.
Jaewoong Lee, Mark E Robinson, Ruifeng Sun, Kohei Kume, Ning Ma, Eric Meffre

bioRxiv· March 2023

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Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness.
Allan Feng, Emily Y Yang, Andrew Reese Moore, Shaurya Dhingra, Sarah Esther Chang, Eric Meffre

JCI Insight· February 2023

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Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet B cells.
Krisztian Csomos, Boglarka Ujhazi, Peter Blazso, Jose L Herrera, Christopher M Tipton, Eric Meffre

Nat Immunol· August 2022

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A humanized mouse model of chronic COVID-19.
Esen Sefik, Benjamin Israelow, Haris Mirza, Jun Zhao, Rihao Qu, Eric Meffre

Nat Biotechnol· June 2022

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Inflammasome activation in infected macrophages drives COVID-19 pathology.
Esen Sefik, Rihao Qu, Caroline Junqueira, Eleanna Kaffe, Haris Mirza, Eric Meffre

Nature· June 2022

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A Novel AICDA Splice-Site Mutation in Two Siblings with HIGM2 Permits Somatic Hypermutation but Abrogates Mutational Targeting.
Johannes Dirks, Gabriele Haase, Tineke Cantaert, Lea Frey, Moritz Klaas, Eric Meffre

J Clin Immunol· May 2022

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Inflammasome activation in infected macrophages drives COVID-19 pathology.
Esen Sefik, Rihao Qu, Caroline Junqueira, Eleanna Kaffe, Haris Mirza, Eric Meffre

bioRxiv· April 2022

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Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen-Specific Clones.
Salome Glauzy, Brennan Olson, Christopher K May, Daniele Parisi, Christopher Massad, Eric Meffre

Arthritis Rheumatol· February 2022

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High-throughput identification of autoantibodies that target the human exoproteome.
Eric Y Wang, Yile Dai, Connor E Rosen, Monica M Schmitt, Mei X Dong, Eric Meffre

Cell Rep Methods· February 2022

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Positive and negative selection shape the human naive B cell repertoire.
Jeff W Chen, Jean-Nicolas Schickel, Nikolaos Tsakiris, Joel Sng, Florent Arbogast, Eric Meffre

J Clin Invest· January 2022

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Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections.
Allan Feng, Emily Yang, Andrew Moore, Shaurya Dhingra, Sarah Chang, Eric Meffre

Res Sq· January 2022

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Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Teresa Sadras, Mickaël Martin, Kohei Kume, Mark E Robinson, Supraja Saravanakumar, Eric Meffre

Mol Cell· May 2021

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A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options.
Esen Sefik, Ben Israelow, Jun Zhao, Rihao Qu, Eric Song, Eric Meffre

Res Sq· March 2021

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Interferon deficiency can lead to severe COVID.
Eric Meffre, Akiko Iwasaki

Nature· November 2020

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