Publications by authors named "Eric R Hantz"

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Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo.
Priyadarshini Jaishankar, Galen J Correy, Yusuke Matsui, Takaya Togo, Moira M Rachman, Eric R Hantz

J Med Chem· December 2025

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Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo.
Priyadarshini Jaishankar, Galen J Correy, Yusuke Matsui, Takaya Togo, Moira M Rachman, Eric R Hantz

bioRxiv· October 2025

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Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus M inhibitors with potent in vivo efficacy.
Tyler C Detomasi, Gilles Degotte, Sijie Huang, Rahul K Suryawanshi, Amy Diallo, Eric R Hantz

Sci Adv· April 2025

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Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship.
Eric R Hantz, Svetlana B Tikunova, Natalya Belevych, Jonathan P Davis, Peter J Reiser

J Chem Inf Model· June 2023

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Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship.
Eric R Hantz, Svetlana B Tikunova, Natalya Belevych, Jonathan P Davis, Peter J Reiser

bioRxiv· February 2023

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The effect of Mg on Ca binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants.
Kaveh Rayani, Eric R Hantz, Omid Haji-Ghassemi, Alison Y Li, Anne M Spuches

FEBS J· December 2022

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Computational Exploration and Characterization of Potential Calcium Sensitizing Mutations in Cardiac Troponin C.
Eric R Hantz, Steffen Lindert

J Chem Inf Model· December 2022

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Actives-Based Receptor Selection Strongly Increases the Success Rate in Structure-Based Drug Design and Leads to Identification of 22 Potent Cancer Inhibitors.
Eric R Hantz, Steffen Lindert

J Chem Inf Model· November 2022

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Applications of machine learning in computer-aided drug discovery.
Sm Bargeen Alam Turzo, Eric R Hantz, Steffen Lindert

QRB Discov· September 2022

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Adaptative Steered Molecular Dynamics Study of Mutagenesis Effects on Calcium Affinity in the Regulatory Domain of Cardiac Troponin C.
Eric R Hantz, Steffen Lindert

J Chem Inf Model· June 2021

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