Publications by authors named "Eric S Diffenderfer"

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First multi-institutional systematic comparison of the neutron ambient dose equivalent produced by proton therapy systems.
Arash Darafsheh, Yao Hao, Anissa Bey, Michele M Kim, Eric S Diffenderfer

Phys Med Biol· November 2025

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Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates.
Andrew M Friberg, Hai Siong Tan, Eric S Diffenderfer, Ioannis Verginadis, Michele M Kim

Phys Med Biol· August 2025

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Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files.
Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Michele M Kim, Rudi Labarbe, Lucian Hotoiu, Eric S Diffenderfer

Med Phys· June 2025

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Proton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee.
Arpit M Chhabra, Richard A Amos, Charles B Simone, Adeel Kaiser, Luis A Perles, Eric S Diffenderfer

Int J Radiat Oncol Biol Phys· May 2025

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FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone.
Ioannis I Verginadis, Anastasia Velalopoulou, Michele M Kim, Kyle Kim, Ioannis Paraskevaidis, Eric S Diffenderfer

Radiother Oncol· April 2025

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FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy.
Haiwei Ni, Zachary J Reitman, Wei Zou, Md Naushad Akhtar, Ritama Paul, Eric S Diffenderfer

Nat Cancer· March 2025

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Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip.
Andrei Georgescu, Joseph Hai Oved, Jonathan H Galarraga, Thomas Cantrell, Samira Mehta, Eric S Diffenderfer

Cell Stem Cell· December 2024

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FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease.
Kyle Kim, Michele M Kim, Giorgos Skoufos, Eric S Diffenderfer, Seyyedeh Azar Oliaei Motlagh

Int J Radiat Oncol Biol Phys· July 2024

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Secondary neutron dosimetry for conformal FLASH proton therapy.
Dixin Chen, Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Rudi Labarbe, Beryl Bell, Eric Stanton Diffenderfer

Med Phys· July 2024

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FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.
Ioannis I Verginadis, Anastasia Velalopoulou, Michele M Kim, Kyle Kim, Ioannis Paraskevaidis, Eric S Diffenderfer

bioRxiv· July 2024

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Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer.
Uri Amit, Ugur Uslu, Ioannis I Verginadis, Michele M Kim, Seyyedeh Azar Oliaei Motlagh, Eric S Diffenderfer

Proc Natl Acad Sci U S A· July 2024

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Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer.
Priyanka Chowdhury, Anastasia Velalopoulou, Ioannis I Verginadis, George Morcos, Phoebe E Loo, Eric S Diffenderfer

Mol Cancer Ther· June 2024

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FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?
Keith A Cengel, Michele M Kim, Eric S Diffenderfer, Theresa M Busch

Semin Radiat Oncol· April 2024

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Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients.
Antonia Rotolo, Eoin C Whelan, Matthew J Atherton, Irina Kulikovskaya, Danuta Jarocha, Eric S Diffenderfer

Cell Rep Med· October 2023

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Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps.
Wei Zou, Rongxiao Zhang, Emil Schüler, Paige A Taylor, Anthony E Mascia, Eric S Diffenderfer

Int J Radiat Oncol Biol Phys· August 2023

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A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply.
Wei Zou, Haram Kim, Eric S Diffenderfer, David J Carlson, Cameron J Koch

Front Oncol· November 2022

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The current status of preclinical proton FLASH radiation and future directions.
Eric S Diffenderfer, Brita S Sørensen, Alejandro Mazal, David J Carlson

Med Phys· March 2022

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Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation.
José Marcio Luna, Andrew R Barsky, Russell T Shinohara, Leonid Roshkovan, Michelle Hershman, Eric S Diffenderfer

Cancers (Basel)· January 2022

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Patient-derived organoids as a platform for modeling a patient's response to chemoradiotherapy in esophageal cancer.
Tatiana A Karakasheva, Joel T Gabre, Uma M Sachdeva, Ricardo Cruz-Acuña, Eric W Lin, Eric S Diffenderfer

Sci Rep· October 2021

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Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model.
Michele M Kim, Ioannis I Verginadis, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Eric S Diffenderfer

Cancers (Basel)· August 2021

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Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery.
Wei Zou, Eric S Diffenderfer, Kan Ota, Paul Boisseau, Michele M Kim

Med Phys· July 2021

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Current delivery limitations of proton PBS for FLASH.
Wei Zou, Eric S Diffenderfer, Keith A Cengel, Michele M Kim, Steve Avery

Radiother Oncol· February 2021

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Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation.
José Marcio Luna, Hann-Hsiang Chao, Russel T Shinohara, Lyle H Ungar, Keith A Cengel, Eric S Diffenderfer

Clin Transl Radiat Oncol· May 2020

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Reply to Nock and Nielsen: On the work of Nock and Nielsen and its relationship to the additive tree.
Gilmer Valdes, José Marcio Luna, Efstathios D Gennatas, Lyle H Ungar, Eric Eaton, Eric S Diffenderfer

Proc Natl Acad Sci U S A· April 2020

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Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System.
Eric S Diffenderfer, Ioannis I Verginadis, Michele M Kim, Khayrullo Shoniyozov, Anastasia Velalopoulou

Int J Radiat Oncol Biol Phys· February 2020

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