Publications by authors named "Erica Pyles"

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Leveraging digestion-assisted capillary electrophoresis sodium dodecyl sulfate (CE-SDS) to monitor galactosylation in monoclonal antibodies.
Ramya Rao, Dylan A Howie, Deanna Di Grandi, Lloydine Clarke, Emily Westin, Erica A Pyles

J Pharm Biomed Anal· November 2025

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A target affinity enrichment workflow to characterize critical post-translational modifications within therapeutic antibodies.
Jethro E Prinston, Wenjing Peng, Kathleen Provoncha, Youmi Moon, Evan Koufos, Erica A Pyles

J Pharm Sci· May 2025

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Comparison of enriched charge variants from different anti-CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post-translational modification.
Jennifer B Nguyen, Sophia Liu, Dylan A Howie, Zachary R Oberholtzer, Eric T Ong, Erica A Pyles

Protein Sci· April 2025

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Comparative analysis of empty and full adeno-associated viruses under stress conditions by anion-exchange chromatography, analytical ultracentrifugation, and mass photometry.
Julia A Townsend, Shuai Li, Laura Sweezy, Nina Liu, Michael P Rosconi, Erica A Pyles

J Pharm Sci· February 2025

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Development of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains.
Gangadhar Dhulipala, Alanna Broszeit, Kun Lu, Nisha Palackal, Erica Pyles

MAbs· November 2024

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Comparison of capillary electrophoresis-based methods for the analytical characterization of purity and stability of in vitro transcribed mRNA.
Prerana Mantri, Bindiya Juneja, Steven Henderson, Evan Koufos, Youmi Moon, Erica A Pyles

J Pharm Biomed Anal· October 2024

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Development of Biolayer Interferometry (BLI)-Based Double-Stranded RNA Detection Method with Application in mRNA-Based Therapeutics and Vaccines.
Dharia Sara Silas, Bindiya Juneja, Keerat Kaur, Muralikrishna Narayanareddy Gari, Yingjian You, Erica A Pyles

Pharmaceutics· September 2024

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Development of a platform method for rapid detection and characterization of domain-specific post-translational modifications in bispecific antibodies.
Sophia Liu, Jennifer B Nguyen, Yimeng Zhao, Svetlana Schussler, Sunnie Kim, Erica A Pyles

J Pharm Biomed Anal· July 2024

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Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA.
Daniel M Dayeh, Jaclyn Cika, Youmi Moon, Steven Henderson, Deanna Di Grandi, Erica A Pyles

J Chromatogr A· May 2024

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Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2.
Sophia Liu, Yuetian Yan, Cody M Secor, Zachary R Oberholtzer, Donna J Skow, Erica A Pyles

MAbs· April 2024

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A single-nucleotide resolution capillary gel electrophoresis workflow for poly(A) tail characterization in the development of mRNA therapeutics and vaccines.
Deanna Di Grandi, Daniel M Dayeh, Keerat Kaur, Yizhuo Chen, Steven Henderson, Erica A Pyles

J Pharm Biomed Anal· November 2023

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Comprehensive biophysical characterization of AAV-AAVR interaction uncovers serotype- and pH-dependent interaction.
Yue Fu, Deepanshu Choudhary, Nina Liu, Youmi Moon, Polat Abdubek, Erica Pyles

J Pharm Biomed Anal· September 2023

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High-sensitivity and high-resolution therapeutic antibody charge variant and impurity characterization by microfluidic native capillary electrophoresis-mass spectrometry.
Zhijie Wu, Hongxia Wang, Jikang Wu, Yu Huang, Xueqing Zhao, Erica A Pyles

J Pharm Biomed Anal· January 2023

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Human Serum Albumin Mitigates Formation of Fatty Acid Particles in Polysorbate-Containing Solutions.
Dorothy M Kim, Kensey Stansberry-Perkins, Michael S Marlow, Erica A Pyles

J Pharm Sci· November 2022

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Deciphering the High Viscosity of a Therapeutic Monoclonal Antibody in High Concentration Formulations by Microdialysis-Hydrogen/Deuterium Exchange Mass Spectrometry.
Xiaobin Xu, Aming Zhang, Yingjie Xu, Yuan Cao, Stephen Cale, Erica A Pyles

J Pharm Sci· May 2022

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A Biparatopic Antibody That Modulates MET Trafficking Exhibits Enhanced Efficacy Compared with Parental Antibodies in MET-Driven Tumor Models.
John O DaSilva, Katie Yang, Andres E Perez Bay, Julian Andreev, Peter Ngoi, Erica Pyles

Clin Cancer Res· March 2020

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Mitigating target interference in bridging immunogenicity assay with target-blocking reagents and mild basic pH.
Jihua Chen, John Garlits, Gangadhar Dhulipala, Thanoja Sirimanne, Colleen Xu, Erica Pyles

Bioanalysis· September 2019

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Matrix interference from Fc-Fc interactions in immunoassays for detecting human IgG4 therapeutics.
Michael A Partridge, Elif Kabuloglu Karayusuf, Gangadhar Dhulipala, Robert Dreyer, Thomas Daly, Erica Pyles

Bioanalysis· August 2016

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Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes.
Douglas A MacDonald, Joel Martin, Kathir K Muthusamy, Jiann-Kae Luo, Erica Pyles

Angiogenesis· July 2016

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Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab.
Nicholas Papadopoulos, Joel Martin, Qin Ruan, Ashique Rafique, Michael P Rosconi, Erica A Pyles

Angiogenesis· June 2012

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VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.
John S Rudge, Jocelyn Holash, Donna Hylton, Michelle Russell, Shelly Jiang, Erica A Pyles

Proc Natl Acad Sci U S A· November 2007

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Cytokine traps: multi-component, high-affinity blockers of cytokine action.
Aris N Economides, Laura Rocco Carpenter, John S Rudge, Vivien Wong, Ellen M Koehler-Stec, Erica A Pyles

Nat Med· January 2003

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