Publications by authors named "Essmat M El-Sheref"

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Design, synthesis, and antiproliferative activity of new 2-amino-pyrano[3,2-]quinoline-3-carbonitriles as potential EGFR, BRAF, and HER-2 inhibitors.
Lamya H Al-Wahaibi, Aliaa M Mohassab, Safwat M Rabea, Bahaa G M Youssif, Stefan Bräse, Essmat M El-Sheref

RSC Adv· October 2025

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Design, synthesis, and biological evaluation of novel quinoline-based EGFR/HER-2 dual-target inhibitors as potential anti-tumor agents.
Lamya H Al-Wahaibi, Essmat M El-Sheref, Hendawy N Tawfeek, Hesham A Abou-Zied, Safwat M Rabea

RSC Adv· October 2024

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Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF inhibitors.
Lamya H Al-Wahaibi, Bahaa G M Youssif, Hesham A Abou-Zied, Stefan Bräse, Alan B Brown, Essmat M El-Sheref

RSC Med Chem· July 2024

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Convenient synthesis and X-ray determination of 2-amino-6-1,3,4-thiadiazin-3-ium bromides endowed with antiproliferative activity.
Hendawy N Tawfeek, Alshaimaa Abdelmoez, Kholood A Dahlous, Bahaa G M Youssif, Stefan Bräse, Essmat M El-Sheref

RSC Adv· May 2024

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Stereoselective synthesis and X-ray structure determination of novel 1,2-dihydroquinolinehydrazonopropanoate derivatives.
Hendawy N Tawfeek, Ahmed M Tawfeek, Stefan Bräse, Martin Nieger, Essmat M El-Sheref

Heliyon· February 2024

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Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1)-ones as Multi-Target Inhibitors.
Essmat M El-Sheref, Stefan Bräse, Hendawy N Tawfeek, Fatmah Ali Alasmary, Bahaa G M Youssif

Int J Mol Sci· August 2023

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Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF Dual Inhibitors Endowed with Antiproliferative Activity.
Lamya H Al-Wahaibi, Essmat M El-Sheref, Alaa A Hassan, S Bräse, M Nieger

Pharmaceuticals (Basel)· July 2023

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One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF Inhibitors.
Lamya H Al-Wahaibi, Essmat M El-Sheref, Mohamed M Hammouda, Bahaa G M Youssif

Pharmaceuticals (Basel)· March 2023

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Design, Synthesis and Biological Evaluation of and -like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action.
Essmat M El-Sheref, Mohamed A Ameen, Kamal M El-Shaieb, Fathy F Abdel-Latif, Asmaa I Abdel-Naser

Molecules· December 2022

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Synthesis of novel amidines one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties.
Essmat M El-Sheref, Hendawy N Tawfeek, Alaa A Hassan, S Bräse, Mohammed A I Elbastawesy

Front Chem· November 2022

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Design and Synthesis of (2--1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents.
Essmat M El-Sheref, Mohammed A I Elbastawesy, Alan B Brown, Ahmed M Shawky, Hesham A M Gomaa

Molecules· November 2021

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Synthesis of potentially new schiff bases of -substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents.
Mohammed B Alshammari, Mohamed Ramadan, Ashraf A Aly, Essmat M El-Sheref, Md Afroz Bakht

J Mol Struct· April 2021

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Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/-2(1)-Quinolinone Hybrids.
Essmat M El-Sheref, Ashraf A Aly, Mohammed B Alshammari, Alan B Brown, Sara Mohamed Naguib Abdel-Hafez

Molecules· October 2020

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4-Hydroxy-2-quinolones: syntheses, reactions and fused heterocycles.
Ashraf A Aly, Essmat M El-Sheref, Aboul-Fetouh E Mourad, Momtaz E M Bakheet, Stefan Bräse

Mol Divers· May 2020

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Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma.
Ashraf A Aly, Essmat M El-Sheref, Momtaz E M Bakheet, Mai A E Mourad, Stefan Bräse

Bioorg Chem· February 2019

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Synthesis of novel 1,2-bis-quinolinyl-1,4-naphthoquinones: ERK2 inhibition, cytotoxicity and molecular docking studies.
Ashraf A Aly, Essmat M El-Sheref, Momtaz E M Bakheet, Mai A E Mourad, Alan B Brown

Bioorg Chem· December 2018

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Synthesis and antibacterial activity of 4-aryl-2-(1-substituted ethylidene)thiazoles.
Alaa A Hassan, Yusria R Ibrahim, Essmat M El-Sheref, Mohamed Abdel-Aziz, Stefan Bräse

Arch Pharm (Weinheim)· July 2013

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