Publications by authors named "Eva Prchalova"

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Discovery of -Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Kateřina Novotná, Lukáš Tenora, Eva Prchalová, James Paule, Jesse Alt

J Med Chem· November 2023

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Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor.
Run-Duo Gao, Niyada Hin, Eva Prchalová, Arindom Pal, Jenny Lam

Bioorg Med Chem Lett· October 2021

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Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.
Kristen R Hollinger, Xiaolei Zhu, Elizabeth S Khoury, Ajit G Thomas, Kevin Liaw, Eva Prchalova

J Alzheimers Dis· September 2021

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Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Michael T Nedelcovych, Boe-Hyun Kim, Xiaolei Zhu, Lyndah E Lovell, Arena A Manning

J Neuroimmune Pharmacol· September 2021

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Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.
Kristen R Hollinger, Matthew D Smith, Leslie A Kirby, Eva Prchalova, Jesse Alt

Neurol Neuroimmunol Neuroinflamm· November 2019

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Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Robert D Leone, Liang Zhao, Judson M Englert, Im-Meng Sun, Min-Hee Oh, Eva Prchalova

Science· November 2019

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Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Michael T Nedelcovych, Boe-Hyun Kim, Xiaolei Zhu, Lyndah E Lovell, Arena A Manning

J Neuroimmune Pharmacol· September 2019

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Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists.
Eva Prchalová, Niyada Hin, Ajit G Thomas, Vijayabhaskar Veeravalli, Justin Ng

J Med Chem· September 2019

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Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Xiaolei Zhu, Michael T Nedelcovych, Ajit G Thomas, Yuto Hasegawa, Aisa Moreno-Megui, Eva Prchalova

Neuropsychopharmacology· May 2019

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JHU-083 selectively blocks glutaminase activity in brain CD11b cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Xiaolei Zhu, Michael T Nedelcovych, Ajit G Thomas, Yuto Hasegawa, Aisa Moreno-Megui, Eva Prchalova

Neuropsychopharmacology· March 2019

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MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.
Brittany A Riggle, Sanhita Sinharay, William Schreiber-Stainthorp, Jeeva P Munasinghe, Dragan Maric, Eva Prchalova

Proc Natl Acad Sci U S A· December 2018

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N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.
Sarah C Zimmermann, Tomáš Tichý, Jan Vávra, Ranjeet P Dash, C Ethan Slusher

J Med Chem· May 2018

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Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery.
Monika Kopečná, Miloslav Macháček, Eva Prchalová, Petr Štěpánek, Pavel Drašar

Pharm Res· October 2017

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N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
Michael T Nedelcovych, Lukáš Tenora, Boe-Hyun Kim, Jennifer Kelschenbach, Wei Chao

J Med Chem· August 2017

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Dodecyl Amino Glucoside Enhances Transdermal and Topical Drug Delivery via Reversible Interaction with Skin Barrier Lipids.
Monika Kopečná, Miloslav Macháček, Eva Prchalová, Petr Štěpánek, Pavel Drašar

Pharm Res· March 2017

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Medicinal applications of perfluoroalkylated chain-containing compounds.
Eva Prchalová, Ondřej Štěpánek, Stanislav Smrček, Martin Kotora

Future Med Chem· June 2014

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An approach to stereoselective preparation of 3-C-glycosylated D- and L-glucals.
Kamil Parkan, Lukás Werner, Zuzana Lövyová, Eva Prchalová, Ladislav Kniezo

Carbohydr Res· February 2010

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