Publications by authors named "Everett Stone"

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Reciprocal links between methionine metabolism, DNA repair and therapy resistance in glioblastoma.
Navyateja Korimerla, Baharan Meghdadi, Isra Haq, Kari Wilder-Romans, Jie Xu, Everett M Stone

bioRxiv· November 2024

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MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors.
Si Chen, Jiakai Hou, Roshni Jaffery, Ashley Guerrero, Rongjie Fu, Everett M Stone

J Immunother Cancer· September 2024

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Enzymatic depletion of l-Met using an engineered human enzyme as a novel therapeutic strategy for melanoma.
Carly S Wilder, Jennifer Chiou, Anna Battenhouse, Achinto Saha, Zhao Chen, Everett Stone

Mol Carcinog· October 2023

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Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance.
Donjeta Gjuka, Elio Adib, Kendra Garrison, Jianfeng Chen, Yuxue Zhang, Everett Stone

Cancer Cell· October 2023

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Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition.
Achinto Saha, Shengyuan Zhao, Austin Kindall, Carly Wilder, Chelsea A Friedman, Everett Stone

J Exp Clin Cancer Res· May 2023

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Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.
John Blazeck, Christos S Karamitros, Kyle Ford, Catrina Somody, Ahlam Qerqez, Everett Stone

Nat Catal· October 2022

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Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Everett Stone

Nature· August 2022

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Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.
Long Zhang, Charbel S Hobeika, Damir Khabibullin, Deyang Yu, Harilaos Filippakis, Everett Stone

Proc Natl Acad Sci U S A· July 2022

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Leveraging intrinsic flexibility to engineer enhanced enzyme catalytic activity.
Christos S Karamitros, Kyle Murray, Brent Winemiller, Candice Lamb, Everett M Stone

Proc Natl Acad Sci U S A· June 2022

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Cyst(e)inase-Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell Cancer.
Baris Kerimoglu, Candice Lamb, Ryan D McPherson, Ergul Ergen, Everett M Stone

Mol Cancer Ther· March 2022

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Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Everett Stone

Nature· March 2022

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Combinatorial Approaches to Enhance DNA Damage following Enzyme-Mediated Depletion of L-Cys for Treatment of Pancreatic Cancer.
Achinto Saha, Shengyuan Zhao, Zhao Chen, George Georgiou, Everett Stone

Mol Ther· February 2021

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Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis.
Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett Stone

Cell Metab· January 2021

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Conformational Dynamics Contribute to Substrate Selectivity and Catalysis in Human Kynureninase.
Christos S Karamitros, Kyle Murray, Yusuke Sugiyama, Yoichi Kumada, Kenneth A Johnson, Everett M Stone

ACS Chem Biol· December 2020

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Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Wei-Cheng Lu, Achinto Saha, Wupeng Yan, Kendra Garrison, Candice Lamb, Everett Stone

Proc Natl Acad Sci U S A· June 2020

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Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Michael A Badgley, Daniel M Kremer, H Carlo Maurer, Kathleen E DelGiorno, Ho-Joon Lee, Everett Stone

Science· April 2020

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Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11.
Xueting Lang, Michael D Green, Weimin Wang, Jiali Yu, Jae Eun Choi, Everett M Stone

Cancer Discov· December 2019

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Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction.
Thomas Thisted, Zuzana Biesova, Celine Walmacq, Everett Stone, Max Rodnick-Smith

BMC Biotechnol· August 2019

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Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth.
Sabin Kshattry, Achinto Saha, Paul Gries, Stefano Tiziani, Everett Stone

NPJ Precis Oncol· June 2019

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CD8 T cells regulate tumour ferroptosis during cancer immunotherapy.
Weimin Wang, Michael Green, Jae Eun Choi, Miguel Gijón, Paul D Kennedy, Everett Stone

Nature· May 2019

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A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.
Jennifer Yinuo Cao, Aunoy Poddar, Leslie Magtanong, Jennifer H Lumb, Trevor R Mileur, Everett Stone

Cell Rep· February 2019

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Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Todd A Triplett, Kendra C Garrison, Nicholas Marshall, Moses Donkor, John Blazeck, Everett Stone

Nat Biotechnol· September 2018

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Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine.
Ioannis Poursaitidis, Xiaomeng Wang, Thomas Crighton, Christiaan Labuschagne, David Mason, Everett Stone

Cell Rep· March 2017

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Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Wupeng Yan, Everett Stone, Yan Jessie Zhang

Biochemistry· February 2017

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Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.
Shira L Cramer, Achinto Saha, Jinyun Liu, Surendar Tadi, Stefano Tiziani, Everett Stone

Nat Med· January 2017

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