Publications by authors named "Fabrizio Manetti"

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Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor.
Federica Poggialini, Paolo Governa, Chiara Vagaggini, Samuele Maramai, Stefania Lamponi, Fabrizio Manetti

Eur J Pharm Sci· June 2025

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Machine Learning for Predicting the Drug-to-Antibody Ratio (DAR) in the Synthesis of Antibody-Drug Conjugates (ADCs).
Lorenzo Angiolini, Fabrizio Manetti, Ottavia Spiga, Andrea Tafi, Anna Visibelli

J Chem Inf Model· June 2025

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Corrigendum to "Applying molecular hybridization to design a new class of pyrazolo[3,4-d] pyrimidines as Src inhibitors active in hepatocellular carcinoma" [Eur. J. Med. Chem. 280 (2024) 116929].
Salvatore Di Maria, Raffaele Passannanti, Federica Poggialini, Chiara Vagaggini, Alessia Serafinelli, Fabrizio Manetti

Eur J Med Chem· March 2025

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Morita-Baylis-Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands.
Marco Paolino, Giusy Tassone, Paolo Governa, Mario Saletti, Matteo Lami, Fabrizio Manetti

ACS Med Chem Lett· March 2025

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A Comprehensive In Vitro and In Silico Approach for Targeting 4-Hydroxyphenyl Pyruvate Dioxygenase: Towards New Therapeutics for Alkaptonuria.
Giulia Bernardini, Alfonso Trezza, Elena Petricci, Giulia Romagnoli, Demetra Zambardino, Fabrizio Manetti

Int J Mol Sci· March 2025

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Applying molecular hybridization to design a new class of pyrazolo[3,4-d]pyrimidines as Src inhibitors active in hepatocellular carcinoma.
Salvatore Di Maria, Raffaele Passannanti, Federica Poggialini, Chiara Vagaggini, Alessia Serafinelli, Fabrizio Manetti

Eur J Med Chem· December 2024

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Cooperative chemoenzymatic and biocatalytic cascades to access chiral sulfur compounds bearing C(sp)-S stereocentres.
Fei Zhao, Ariane Mattana, Ruqaiya Alam, Sarah L Montgomery, Akash Pandya, Fabrizio Manetti

Nat Commun· September 2024

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Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity.
Hakan Aslan, Gioele Renzi, Andrea Angeli, Ilaria D'Agostino, Roberto Ronca, Fabrizio Manetti

RSC Med Chem· June 2024

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Deletion of 82-85 N-Terminal Residues in SARS-CoV-2 Nsp1 Restricts Virus Replication.
Gianni Gori Savellini, Gabriele Anichini, Fabrizio Manetti, Claudia Immacolata Trivisani, Maria Grazia Cusi

Viruses· April 2024

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Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment.
Chiara Vagaggini, Debora Petroni, Ilaria D'Agostino, Federica Poggialini, Chiara Cavallini, Fabrizio Manetti

Drug Dev Res· February 2024

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Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors.
Paolo Governa, Marco Biagi, Fabrizio Manetti, Stefano Forli

RSC Med Chem· February 2024

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Effect of simulated digestion on the anti- activity of different Propolis extracts.
Paolo Governa, Giulia Romagnoli, Paola Albanese, Federico Rossi, Fabrizio Manetti

J Enzyme Inhib Med Chem· December 2023

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Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol.
Vittoria Borgonetti, Clarissa Caroli, Paolo Governa, Brighenti Virginia, Federica Pollastro, Fabrizio Manetti

Phytother Res· October 2023

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Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth.
Luisa Maresca, Enrica Crivaro, Francesca Migliorini, Giulia Anichini, Alessandro Giammona, Fabrizio Manetti

Pharmacol Res· September 2023

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Antiviral Activity of Cannabidiolic Acid and Its Methyl Ester against SARS-CoV-2.
Martina Tamburello, Stefano Salamone, Lisa Anceschi, Paolo Governa, Virginia Brighenti, Fabrizio Manetti

J Nat Prod· July 2023

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CanB, a Druggable Cellular Target in .
Giulia Degiacomi, Beatrice Gianibbi, Deborah Recchia, Giovanni Stelitano, Giuseppina Ivana Truglio, Fabrizio Manetti

ACS Omega· July 2023

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Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation.
Vittoria Borgonetti, Lisa Anceschi, Virginia Brighenti, Lorenzo Corsi, Paolo Governa, Fabrizio Manetti

Phytother Res· May 2023

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Zingiberene, a non-zinc-binding class I HDAC inhibitor: A novel strategy for the management of neuropathic pain.
Vittoria Borgonetti, Paolo Governa, Fabrizio Manetti, Nicoletta Galeotti

Phytomedicine· March 2023

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Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors.
Salvatore Princiotto, Loana Musso, Fabrizio Manetti, Valentina Marcellini, Giovanni Maga

J Enzyme Inhib Med Chem· December 2022

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Investigation on the neuroprotective effect of a cannabidiol-enriched non-psychotropic Cannabis sativa L. extract in an in vitro model of excitotoxicity.
Vittoria Borgonetti, Marco Biagi, Nicoletta Galeotti, Fabrizio Manetti, Paolo Governa

Fitoterapia· November 2022

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Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening.
Fabrizio Manetti, Luisa Maresca, Enrica Crivaro, Sara Pepe, Elena Cini

ACS Med Chem Lett· August 2022

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Tapping into the antitubercular potential of 2,5-dimethylpyrroles: A structure-activity relationship interrogation.
Dorothy Semenya, Meir Touitou, Domiziana Masci, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Fabrizio Manetti

Eur J Med Chem· July 2022

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Survey on the Recent Advances in 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibition by Diketone and Triketone Derivatives and Congeneric Compounds: Structural Analysis of HPPD/Inhibitor Complexes and Structure-Activity Relationship Considerations.
Paolo Governa, Giulia Bernardini, Daniela Braconi, Fabrizio Manetti, Annalisa Santucci

J Agric Food Chem· June 2022

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Non-psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors-, endocannabinoids-, and NF-κB-mediated signaling.
Vittoria Borgonetti, Cristina Benatti, Paolo Governa, Giovanni Isoldi, Federica Pellati, Fabrizio Manetti

Phytother Res· May 2022

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Structural Rigidification of -Aryl-pyrroles into Indoles Active against Intracellular and Drug-Resistant Mycobacteria.
Dorothy Semenya, Meir Touitou, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Luca Pisano, Fabrizio Manetti

ACS Med Chem Lett· January 2022

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