Publications by authors named "Fengrong Xu"

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Dual degradation mechanism of GPX4 degrader in induction of ferroptosis exerting anti-resistant tumor effect.
Chao Wang, Cangxin Zheng, Han Wang, Sufang Shui, Hongwei Jin, Fengrong Xu, Ping Xu

Eur J Med Chem· February 2023

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Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes.
Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Ping Xu

Biochem Pharmacol· March 2022

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Research progress of MEK1/2 inhibitors and degraders in the treatment of cancer.
Chao Wang, Han Wang, Cangxin Zheng, Zhenming Liu, Xiaozuo Gao, Fengrong Xu, Ping Xu

Eur J Med Chem· June 2021

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Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors.
Zirui Lü, Xiaona Li, Kebin Li, Cong Wang, Tingting Du, Fengrong Xu, Ping Xu

ACS Med Chem Lett· May 2021

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Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules.
Xiaona Li, Zirui Lü, Cong Wang, Kebin Li, Fengrong Xu, Ping Xu

ACS Med Chem Lett· May 2021

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Early Diagnosis of Cerebral Ischemia Reperfusion Injury and Revelation of Its Regional Development by a HR Receptor-Directed Probe.
Junda Wang, Yuanjun Zhu, Lingfei Yang, Hui Liu, Tongliang Zhou, Fengrong Xu, Ping Xu

ACS Sens· March 2021

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Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs.
Chao Wang, Dandan Xi, Han Wang, Yan Niu, Lei Liang, Fengrong Xu, Ping Xu

Eur J Med Chem· June 2020

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A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging.
Tongliang Zhou, Junda Wang, Jiamin Xu, Cangxin Zheng, Yan Niu, Fengrong Xu, Ping Xu

Anal Chem· April 2020

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Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome.
Qi Sun, Tongliang Zhou, Dandan Xi, Xiaona Li, Zirui Lü, Fengrong Xu, Ping Xu

Eur J Med Chem· April 2020

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Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening.
Dandan Xi, Yan Niu, Hongyue Li, Stefan M Noha, Veronika Temml, Fengrong Xu, Ping Xu

Eur J Med Chem· September 2019

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Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors.
Hongyue Li, Dandan Xi, Yan Niu, Chao Wang, Fengrong Xu, Ping Xu

J Inorg Biochem· June 2019

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Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors.
Xiufeng Xu, Peng Lü, Junjie Wang, Fengrong Xu, Lei Liang, Ping Xu

Chem Biol Drug Des· May 2019

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2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies.
Gang Yan, Lina Hao, Yan Niu, Wenjie Huang, Wei Wang, Fengrong Xu, Ping Xu

Eur J Med Chem· September 2017

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Discovery of a cobalt complex with high MEK1 binding affinity.
Hongyue Li, Tongliang Zhou, Hui Liu, Fengrong Xu, Yan Niu, Ping Xu

Bioorg Med Chem Lett· May 2017

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Discovery of a potent and highly specific β proteasome inhibitor from a library of copper complexes.
Tongliang Zhou, Yuanbo Cai, Lei Liang, Lingfei Yang, Fengrong Xu, Ping Xu

Bioorg Med Chem Lett· December 2016

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Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents.
Jing Sun, Yan Niu, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Ping Xu

Bioorg Med Chem· August 2016

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Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging.
Lingfei Yang, Yuanjun Zhu, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Fengrong Xu, Ping Xu

Chemistry· August 2016

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Development of novel proteasome inhibitors based on phthalazinone scaffold.
Lingfei Yang, Wei Wang, Qi Sun, Fengrong Xu, Yan Niu, Ping Xu

Bioorg Med Chem Lett· June 2016

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Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors.
Qi Sun, Bo Xu, Yan Niu, Fengrong Xu, Lei Liang, Ping Xu

ChemMedChem· March 2015

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4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies.
Peng Liu, Yan Niu, Chao Wang, Qi Sun, Yaya Zhai, Fengrong Xu, Ping Xu

Eur J Med Chem· May 2014

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Rational design, green synthesis, and initial evaluation of a series of full-color tunable fluorescent dyes enabled by the copper-catalyzed N-arylation of 6-phenyl pyridazinones and their application in cell imaging.
Lei Liang, Wei Wang, Jun Wu, Fengrong Xu, Yan Niu, Bo Xu, Ping Xu

Chemistry· October 2013

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Relay catalysis by a multifunctional Cu catalyst in a tandem dehydro-/dehalogenation sequence along with N-arylation.
Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu

Org Lett· June 2013

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Substituted 3-benzylcoumarins as allosteric MEK1 inhibitors: design, synthesis and biological evaluation as antiviral agents.
Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu, Yun Wu, Ping Xu

Molecules· May 2013

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Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors.
Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Ping Xu

Chem Biol Drug Des· November 2012

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The discovery of novel β-secretase inhibitors: pharmacophore modeling, virtual screening, and docking studies.
Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Ping Xu

Chem Biol Drug Des· June 2012

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