Publications by authors named "Fengwei Lin"

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Scaffold hopping-based structural modification of tranilast led to the identification of HNW005 as a promising NLRP3 inflammasome and URAT1 dual inhibitor for the treatment of gouty arthritis.
Ming Sun, Fengwei Lin, Chenchen Yue, Zijie Wei, Chang Liu

Eur J Med Chem· August 2025

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Design, Synthesis, and Biological Evaluation of Heterocycle-Fused Celastrol Derivatives as Potent Antiosteoporosis Agents by Blocking RANKL-Induced Activation of the NF-κB and MAPK Signaling Pathways.
Xuefeng Fu, Chengjun Wu, Wen Jiang, Yang Jiao, Jiahui Wang, Fengwei Lin, Lin Tao

J Med Chem· August 2025

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Design, synthesis and biological evaluation of 2-[1-(pyridin-2-ylmethyl)-1H-pyrazole-3-carboxamido]benzoic acids as promising urate transporter 1 inhibitors with potential nephroprotective efficacy for the treatment of hyperuricemic nephropathy.
Qing Mao, Peng Zhang, Fengwei Lin, Xuefeng Fu, Bing Zhang

Eur J Med Chem· June 2025

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Design, Synthesis, and Biological Evaluation of 4-(Difluoromethyl)-1-imidazole-5-carboxylic Acids/4-(3-Cyanophenoxy)pyrimidine-5-carboxylic Acids as P2Y Receptor Antagonists for Ischemic Stroke Treatment.
Bing Zhang, Jinxin Li, Qi Li, Qiuhua Li, Ruyu Wang, Fengwei Lin

J Med Chem· June 2025

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Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells.
Xuefeng Fu, Yang Jiao, Yao Feng, Fengwei Lin, Bing Zhang

J Nat Prod· August 2024

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Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase.
Fengwei Lin, Ming Sun, Jun Gao, Bing Zhang, Qing Mao

Eur J Med Chem· September 2023

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Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway.
Xuefeng Fu, Qing Mao, Bing Zhang, Jialun Lv, Kunqi Ping, Fengwei Lin

J Nat Prod· April 2022

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Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.
Yao Feng, Bing Zhang, Jialun Lv, Peng Zhang, Qing Mao, Fengwei Lin, Zhaolin Li

Eur J Med Chem· April 2022

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Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA-PABA-MAC and 5-ASA-PABA-Diamine for the Treatment of Ulcerative Colitis.
Jiaxing Zhao, Bing Zhang, Qing Mao, Kunqi Ping, Peng Zhang, Fengwei Lin

J Med Chem· March 2022

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Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.
Jiaxing Zhao, Qing Mao, Fengwei Lin, Bing Zhang, Ming Sun

Eur J Med Chem· February 2022

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Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Bing Zhang, Yulin Duan, Yuwei Yang, Qing Mao, Fengwei Lin

Eur J Med Chem· January 2022

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Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.
Ming Sun, Jiaxing Zhao, Qing Mao, Chengda Yan, Bing Zhang, Fengwei Lin, Yulin Duan

Bioorg Med Chem· May 2021

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Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y and P2Y as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.
Yu Lei, Bing Zhang, Dan Liu, Jian Zhao, Xiwen Dai, Fengwei Lin, Yulin Duan

J Med Chem· December 2020

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Rapid MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor.
Feng-Wei Lin, Pin-Yuan Chen, Kuo-Chen Wei, Chiung-Yin Huang, Chih-Kuang Wang

Theranostics· March 2018

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Co-Delivery of Docetaxel and p44/42 MAPK siRNA Using PSMA Antibody-Conjugated BSA-PEI Layer-by-Layer Nanoparticles for Prostate Cancer Target Therapy.
See-Tong Pang, Feng-Wei Lin, Cheng-Keng Chuang, Hung-Wei Yang

Macromol Biosci· May 2017

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1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance-fluorescence imaging for tracking of chemotherapeutic agents.
Kuo-Chen Wei, Feng-Wei Lin, Chiung-Yin Huang, Chen-Chi M Ma, Ju-Yu Chen

Int J Nanomedicine· February 2017

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Synthesis and evaluation of the alpha-glucosidase inhibitory activity of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives.
Shaojie Wang, Jufang Yan, Xiaoyan Wang, Zhuo Yang, Fengwei Lin

Eur J Med Chem· March 2010

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