Publications by authors named "Flavia Varano"

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8-Amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives hybridized with antioxidants: new highly potent and selective human A adenosine receptor antagonists as useful agents against cerebral ischemia.
Sara Calenda, Costanza Ceni, Daniela Catarzi, Flavia Varano, Giulia Vagnoni

Bioorg Chem· September 2025

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Structural Simplification from Tricyclic to Bicyclic Scaffolds: A Long-Term Investigation in the Field of Adenosine Receptor Antagonists.
Costanza Ceni, Sara Calenda, Giulia Vagnoni, Daniela Catarzi, Flavia Varano

Cells· September 2025

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Repurposing the amino-3,5-dicyanopyridine scaffold from adenosine receptor ligands to carbonic anhydrase activators.
Erica Vigiani, Alessandro Bonardi, Daniela Catarzi, Flavia Varano, Sara Calenda

Eur J Med Chem· July 2025

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Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta.
Sara Calenda, Daniela Catarzi, Flavia Varano, Erica Vigiani, Rosaria Volpini

Pharmaceuticals (Basel)· April 2024

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Pharmacological Characterization of P626, a Novel Dual Adenosine A/A Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus.
Martina Venturini, Federica Cherchi, Clara Santalmasi, Lucia Frulloni, Ilaria Dettori, Flavia Varano

Biomolecules· May 2023

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"Dual Anta-Inhibitors" of the A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies.
Andrea Spinaci, Michela Buccioni, Daniela Catarzi, Chang Cui, Vittoria Colotta, Flavia Varano

Pharmaceuticals (Basel)· January 2023

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A Adenosine Receptor Antagonists and their Potential in Neurological Disorders.
Catia Lambertucci, Gabriella Marucci, Daniela Catarzi, Vittoria Colotta, Beatrice Francucci, Flavia Varano

Curr Med Chem· August 2022

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Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders.
Daniela Catarzi, Flavia Varano, Erica Vigiani, Catia Lambertucci, Andrea Spinaci

Curr Med Chem· August 2022

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CK1 delta inhibition: an emerging strategy to combat neurodegenerative diseases.
Flavia Varano, Daniela Catarzi, Sara Calenda, Erica Vigiani, Vittoria Colotta

Future Med Chem· August 2022

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4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives.
Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani

Pharmaceuticals (Basel)· April 2022

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Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A and A Receptors, and Efficacy in Animal Models of Depression.
Flavia Varano, Daniela Catarzi, Erica Vigiani, Diego Dal Ben, Michela Buccioni

Pharmaceuticals (Basel)· July 2021

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Special Issue "Adenosine Receptors as Attractive Targets in Human Diseases".
Daniela Catarzi, Flavia Varano, Vittoria Colotta

Pharmaceuticals (Basel)· February 2021

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Discovery of first-in-class multi-target adenosine A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents.
Costanza Ceni, Daniela Catarzi, Flavia Varano, Diego Dal Ben, Gabriella Marucci

Eur J Med Chem· September 2020

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Adenosine A receptors inhibit K currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway.
Elisabetta Coppi, Federica Cherchi, Irene Fusco, Ilaria Dettori, Lisa Gaviano, Flavia Varano

Biochem Pharmacol· July 2020

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Piperazine- and Piperidine-Containing Thiazolo[5,4-]pyrimidine Derivatives as New Potent and Selective Adenosine A Receptor Inverse Agonists.
Flavia Varano, Daniela Catarzi, Erica Vigiani, Fabrizio Vincenzi, Silvia Pasquini

Pharmaceuticals (Basel)· July 2020

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New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A adenosine receptor antagonists.
Matteo Falsini, Costanza Ceni, Daniela Catarzi, Flavia Varano, Diego Dal Ben

Bioorg Med Chem Lett· June 2020

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Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A receptor as potential antitumor agents.
Flavia Varano, Daniela Catarzi, Fabrizio Vincenzi, Silvia Pasquini, Julie Pelletier

Bioorg Med Chem Lett· May 2020

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Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging from Pan Ligands to Combined A/A Partial Agonists.
Daniela Catarzi, Flavia Varano, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini

Pharmaceuticals (Basel)· October 2019

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Functional characterization of a novel adenosine A receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus.
Irene Fusco, Federica Cherchi, Daniela Catarzi, Vittoria Colotta, Flavia Varano

Brain Res Bull· September 2019

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Antioxidant-Conjugated 1,2,4-Triazolo[4,3-]pyrazin-3-one Derivatives: Highly Potent and Selective Human A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain.
Matteo Falsini, Daniela Catarzi, Flavia Varano, Costanza Ceni, Diego Dal Ben

J Med Chem· September 2019

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Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.
Marco Betti, Daniela Catarzi, Flavia Varano, Matteo Falsini, Katia Varani

J Med Chem· August 2019

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Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A and A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells.
Matteo Falsini, Daniela Catarzi, Flavia Varano, Diego Dal Ben, Gabriella Marucci

Bioorg Chem· June 2019

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Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity.
Flavia Varano, Daniela Catarzi, Matteo Falsini, Diego Dal Ben, Michela Buccioni

Bioorg Med Chem Lett· February 2019

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Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A and A adenosine receptor antagonists/inverse agonists.
Flavia Varano, Daniela Catarzi, Matteo Falsini, Fabrizio Vincenzi, Silvia Pasquini

Bioorg Med Chem· July 2018

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Structure-activity relationship studies and pharmacological characterization of N-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A adenosine receptor.
Flavia Varano, Daniela Catarzi, Fabrizio Vincenzi, Matteo Falsini, Silvia Pasquini

Eur J Med Chem· July 2018

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