Publications by authors named "Flora Sam"

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Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial.
Barry A Borlaug, Jeffrey M Testani, Mark C Petrie, Zhenzhong Wang, Jonathan Cunningham, Flora Sam

Nat Med· November 2025

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Metabolic dysregulation in the heart in obesity-associated HFpEF.
Maria Valero-Muñoz, Hannah L Cooper, Shanpeng Li, Eng Leng Saw, Richard M Wilson, Flora Sam

Front Cardiovasc Med· October 2025

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Association of Long-Term Body Mass Index Variability With the Development of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction Across Patterns of Weight Change.
Zeshui Yu, Yuqing Chen, Oshin Miranda, Meiyuzhen Qi, Manling Zhang, Flora Sam

J Am Heart Assoc· September 2025

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White Adipose Tissue in Obesity-Associated HFpEF: Insights From Mice and Humans.
María Valero-Muñoz, Eng Leng Saw, Hannah Cooper, David R Pimentel, Flora Sam

JACC Basic Transl Sci· August 2025

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Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction.
Eng Leng Saw, Louis Dominic Werner, Hannah L Cooper, David R Pimental, Payman Zamani, Flora Sam

Circ Heart Fail· June 2025

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LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer.
Siyu Han, Shixiang Yu, Mengya Shi, Makoto Harada, Jianhong Ge, Flora Sam

Nat Commun· April 2025

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Volenrelaxin (LY3540378) increases renal plasma flow: a randomized Phase 1 trial.
Lai San Tham, Hiddo J L Heerspink, Xiaojun Wang, Petra Verdino, Chadi G Saifan, Flora Sam

Nephrol Dial Transplant· December 2024

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Endothelin-1: Is it Time to "Biomark" the Cardiac-Tumor-Treatment Nexus in Breast Cancer?
María Valero-Muñoz, Flora Sam

JACC CardioOncol· October 2023

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Weight-dependent and weight-independent effects of dulaglutide on blood pressure in patients with type 2 diabetes.
Keith C Ferdinand, Julia Dunn, Claudia Nicolay, Flora Sam, Emily K Blue

Cardiovasc Diabetol· March 2023

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Correction: Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications.
Fatima El-Adili, Justin K Lui, Mortada Najem, Giuseppina Farina, Maria Trojanowska, Flora Sam

Arthritis Res Ther· January 2023

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Skeletal muscle phenotypic switching in heart failure with preserved ejection fraction.
Eng Leng Saw, Louis Dominic Werner, Payman Zamani, Julio A Chirinos, María Valero-Muñoz, Flora Sam

Front Cardiovasc Med· December 2022

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Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications.
Fatima El-Adili, Justin K Lui, Mortada Najem, Giuseppina Farina, Maria Trojanowska, Flora Sam

Arthritis Res Ther· November 2022

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Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF).
María Valero-Muñoz, Eng Leng Saw, Ryan M Hekman, Benjamin C Blum, Zaynab Hourani, Flora Sam

Front Cardiovasc Med· August 2022

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A misdirected conundrum in translational HFpEF research.
María Valero-Muñoz, Flora Sam

J Mol Cell Cardiol· July 2022

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Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models.
Jason Roh, Joseph A Hill, Abhilasha Singh, María Valero-Muñoz, Flora Sam

Circ Res· June 2022

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Endothelial-Mesenchymal Transition in Heart Failure With a Preserved Ejection Fraction: Insights Into the Cardiorenal Syndrome.
María Valero-Muñoz, Albin Oh, Elizabeth Faudoa, Rosa Bretón-Romero, Fatima El Adili, Flora Sam

Circ Heart Fail· September 2021

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Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.
Ambarish Pandey, Sanjiv J Shah, Javed Butler, Dean L Kellogg, Gregory D Lewis, Flora Sam

J Am Coll Cardiol· September 2021

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Reply to letter by Hou et al., Doxycycline ameliorates autophagy by inhibiting p38 MAPK in cardiac myocytes.
María Valero-Muñoz, Flora Sam

Int J Cardiol· May 2021

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Reply to letter by Ye et al., blocking lncRNA H19/miR-194-5p/SIRT1 axis in cardiac myocyte is responsible for doxycycline inhibiting autophagy.
María Valero-Muñoz, Flora Sam

Int J Cardiol· May 2021

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Skeletal muscle (dys)function in heart failure with preserved ejection fraction.
Eng Leng Saw, Swetha Ramachandran, Maria Valero-Muñoz, Flora Sam

Curr Opin Cardiol· March 2021

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Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes.
María Valero-Muñoz, Richard M Wilson, Rosa Bretón-Romero, Dominique Croteau, David C Seldin, Flora Sam

Int J Cardiol· December 2020

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Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary.
Sanjiv J Shah, Barry A Borlaug, Dalane W Kitzman, Andrew D McCulloch, Burns C Blaxall, Flora Sam

Circulation· March 2020

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Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study.
Sheraz A Butt, Jørgen L Jeppesen, Christian Torp-Pedersen, Flora Sam, Gunnar H Gislason

J Am Heart Assoc· September 2019

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Heart Failure With Preserved Ejection Fraction and Adipose Tissue: A Story of Two Tales.
Albin Oh, Ross Okazaki, Flora Sam, Maria Valero-Muñoz

Front Cardiovasc Med· August 2019

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Predictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure.
Usman A Tahir, Gheorghe Doros, John S Kim, Lawreen H Connors, David C Seldin, Flora Sam

Sci Rep· June 2019

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