Publications by authors named "Floris van Alphen"

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mTOR signaling during T cell activation promotes cytokine production in T cells through 3' UTR-mediated translation control.
Anouk P Jurgens, Josephine Zwijnen, Antonia Bradarić, Floris P J van Alphen, Kaspar Bresser

Mol Cell· December 2025

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The RhoGEF Trio regulates the formation of tensile linear endothelial junctions to improve barrier function.
Jos van Rijssel, Thijs J Sluiter, Jeffrey M A van der Krogt, Cindy I Bart, Juan Zhang, Floris P J van Alphen

Mol Biol Cell· December 2025

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Trp1250, Lys1252, and Arg1367 of ADAMTS13 comprise a hot spot for anti-CUB domain antibodies in patients with iTTP.
Tim Postmus, Robin Jansen, Paul Kaijen, Floris van Alphen, Carmen van der Zwaan

Blood Adv· October 2025

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Proteolytic signatures of coagulation identified by plasma peptidomics.
Jessica Del Castillo Alferez, Alette Kooiker, Floris P J van Alphen, Carmen van der Zwaan, Herm-Jan Brinkman

J Thromb Haemost· August 2025

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FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4.
Mariarosaria Miranda, Bjarke Endel Hansen, Batoul Wehbi, Valeria Porcheddu, Floris P J Van Alphen

Haematologica· June 2025

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Exploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A.
Mariarosaria Miranda, Eelke Brandsma, Lotte Robben, Helena Van Dender, Floris P J van Alphen

J Thromb Haemost· March 2025

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Integrative phosphoproteomic analyses reveal hemostatic-endothelial signaling interplay.
Stijn A Groten, Bart L van den Eshof, Floris P J van Alphen, Alexander B Meijer, Maartje van den Biggelaar

J Thromb Haemost· February 2025

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Tumor-Expressed SPPL3 Supports Innate Antitumor Immune Responses.
Tamara Verkerk, Antonius A de Waard, Sofie J I Koomen, Jasper Sanders, Tineke Jorritsma, Floris P J van Alphen

Eur J Immunol· February 2025

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Plasma Profiling of Acute Myeloid Leukemia With Fever- and Infection-Related Complications During Chemotherapy-Induced Neutropenia.
Iris C Kreft, Annemarie van de Geer, Eva R Smit, Carmen van der Zwaan, Floris P J van Alphen

Cancer Rep (Hoboken)· October 2024

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Intestinal tissue-resident memory T cells maintain distinct identity from circulating memory T cells after in vitro restimulation.
Ammarina Beumer-Chuwonpad, Felix M Behr, Floris P J van Alphen, Natasja A M Kragten, Arie J Hoogendijk

Eur J Immunol· May 2024

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Platelet proteomic profiling in sitosterolemia suggests thrombocytopenia is driven by lipid disorder and not platelet aberrations.
Jessica Del Castillo, Anton T J Tool, Karin van Leeuwen, Floris P J van Alphen, Marion M Brands

Blood Adv· May 2024

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SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function.
Panagiota Bouti, Bart J A M Klein, Paul J H Verkuijlen, Karin Schornagel, Floris P J van Alphen

Front Immunol· March 2024

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Endothelial ICAM-1 Adhesome Recruits CD44 for Optimal Transcellular Migration of Human CTLs.
Abraham C I van Steen, Max L B Grönloh, Sander Joosten, Floris van Alphen, Maartje van den Biggelaar

J Immunol· August 2023

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Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function.
Branka Popović, Benoît P Nicolet, Aurélie Guislain, Sander Engels, Anouk P Jurgens, Floris P J van Alphen

Cell Rep· May 2023

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Multi-omics delineation of cytokine-induced endothelial inflammatory states.
Stijn A Groten, Eva R Smit, Esmée F J Janssen, Bart L van den Eshof, Floris P J van Alphen

Commun Biol· May 2023

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Mass spectrometry-based analysis on the impact of whole blood donation on the global plasma proteome.
Iris C Kreft, Arie J Hoogendijk, Carmen van der Zwaan, Floris P J van Alphen, Mariette Boon-Spijker

Transfusion· March 2023

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Memory CD8 T cells upregulate glycolysis and effector functions under limiting oxygen conditions.
Ammarina Beumer-Chuwonpad, Floris P J van Alphen, Natasja A M Kragten, Julian J Freen-van Heeren, Maria Rodriguez Gomez

Eur J Immunol· February 2023

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Proteomic landscapes of inherited platelet disorders with different etiologies.
Iris C Kreft, Elise J Huisman, Marjon H Cnossen, Floris P J van Alphen, Carmen van der Zwaan

J Thromb Haemost· February 2023

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Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture.
Marije Kat, Ellie Karampini, Arie J Hoogendijk, Petra E Bürgisser, Aat A Mulder, Floris P J Van Alphen

Haematologica· August 2022

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Neutrophil azurophilic granule glycoproteins are distinctively decorated by atypical pauci- and phosphomannose glycans.
Karli R Reiding, Yu-Hsien Lin, Floris P J van Alphen, Alexander B Meijer, Albert J R Heck

Commun Biol· August 2021

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Probing activation-driven changes in coagulation factor IX by mass spectrometry.
Nadia Freato, Floris P J van Alphen, Mariëtte Boon-Spijker, Maartje van den Biggelaar, Alexander B Meijer

J Thromb Haemost· June 2021

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N-glycan-mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP.
Bogac Ercig, Nuno A G Graça, Kadri Kangro, Tom Arfman, Kanin Wichapong, Floris P J van Alphen

Blood· May 2021

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Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote Expansion of Hematopoietic Stem and Progenitor Cells.
Corina A Ghebes, Jess Morhayim, Marion Kleijer, Merve Koroglu, Stefan J Erkeland, Floris P J van Alphen

Front Bioeng Biotechnol· February 2021

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Factor VIII-driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry.
Nadia Freato, Eduard H T M Ebberink, Josse van Galen, Caroline Fribourg, Mariëtte Boon-Spijker, Floris P J van Alphen

Blood· December 2020

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Loss-of-function mutations in CSF3R cause moderate neutropenia with fully mature neutrophils: two novel pedigrees.
Evelien G G Sprenkeler, Anton T J Tool, Iris C Kreft, Floris P J van Alphen,

Br J Haematol· December 2020

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