Publications by authors named "Francesca Zimetti"

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Optimization of 4-Amino-2-Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure-Activity and Structure-Metabolism Relationships.
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Francesca Zimetti

ChemMedChem· November 2025

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Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer's Disease.
Martina Ugolotti, Bianca Papotti, Alessandro Trentini, Gianmarco Mola, Carlo Cervellati, Francesca Zimetti

Curr Pharm Des· October 2025

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Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9.
Marcella Palumbo, Martina Ugolotti, Francesca Zimetti, Maria Pia Adorni

Atheroscler Plus· March 2025

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Changes in serum cholesterol loading capacity are linked to coronary atherosclerosis progression in rheumatoid arthritis.
George Athanasios Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Francesca Zimetti

RMD Open· December 2024

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Influence of genotype on PCSK9-lipids association in cerebrospinal fluid and serum of patients in the Alzheimer's disease continuum.
Bianca Papotti, Marcella Palumbo, Maria Pia Adorni, Lisa Elviri, Annalisa Chiari, Francesca Zimetti

J Alzheimers Dis· November 2024

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HDL cholesterol efflux capacity and cholesterol loading capacity in long-term fasting: Evidence from a prospective, single-arm interventional study in healthy individuals.
Franziska Grundler, Marcella Palumbo, Maria Pia Adorni, Francesca Zimetti, Bianca Papotti

Atherosclerosis· October 2024

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Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer's Disease in the APPswePS1ΔE9 Mouse Model.
Nikita Martens, Na Zhan, Sammie C Yam, Frank P J Leijten, Marcella Palumbo, Francesca Zimetti

Nutrients· May 2024

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Effect of Empagliflozin with or without the Addition of Evolocumab on HDL Subspecies in Individuals with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the EXCEED-BHS3 Trial.
Isabella Bonilha, Érica Ivana Lázaro Gomes, Helison R P Carmo, Ikaro Breder, Joaquim Barreto, Francesca Zimetti

Int J Mol Sci· April 2024

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Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability.
Lisa Giannessi, Maria Giovanna Lupo, Ilaria Rossi, Maria Grazia Martina, Antonietta Vilella, Francesca Zimetti

Eur J Med Chem· February 2024

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PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice.
Antonietta Vilella, Martina Bodria, Bianca Papotti, Ilaria Zanotti, Francesca Zimetti

Brain Behav Immun· January 2024

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Statins influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis.
George A Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Francesca Zimetti

J Transl Autoimmun· December 2023

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Inflammation and immunomodulatory therapies influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis.
George A Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Francesca Zimetti

J Transl Autoimmun· December 2023

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Effect of the JAK/STAT Inhibitor Tofacitinib on Macrophage Cholesterol Metabolism.
Maria Pia Adorni, Bianca Papotti, Maria Orietta Borghi, Elena Raschi, Francesca Zimetti

Int J Mol Sci· August 2023

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Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer's disease.
Marta Turri, Elisa Conti, Chiara Pavanello, Francesco Gastoldi, Marcella Palumbo, Francesca Zimetti

Alzheimers Res Ther· May 2023

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ATP-binding cassette G1 membrane transporter-mediated cholesterol efflux capacity influences coronary atherosclerosis and cardiovascular risk in Rheumatoid Arthritis.
George A Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Francesca Zimetti

J Autoimmun· April 2023

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Hydroxypropyl-β-Cyclodextrin Depletes Membrane Cholesterol and Inhibits SARS-CoV-2 Entry into HEK293T-ACE Cells.
Silvia Alboni, Valentina Secco, Bianca Papotti, Antonietta Vilella, Maria Pia Adorni, Francesca Zimetti

Pathogens· April 2023

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Role of Lipoprotein Levels and Function in Atherosclerosis Associated with Autoimmune Rheumatic Diseases.
Nicoletta Ronda, Francesca Zimetti, Maria Pia Adorni, Marcella Palumbo, George A Karpouzas

Rheum Dis Clin North Am· February 2023

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Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases.
Na Zhan, Boyang Wang, Nikita Martens, Yankai Liu, Shangge Zhao, Francesca Zimetti

Int J Mol Sci· January 2023

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Effects of Antirheumatic Treatment on Cell Cholesterol Efflux and Loading Capacity of Serum Lipoproteins in Spondylarthropathies.
Ingrid Hokstad, Daniela Greco, Gia Deyab, Morten Wang Fagerland, Stefan Agewall, Francesca Zimetti

J Clin Med· December 2022

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PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer's Disease.
Bianca Papotti, Maria Pia Adorni, Cinzia Marchi, Francesca Zimetti, Nicoletta Ronda

Int J Mol Sci· October 2022

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PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells.
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zarà, Marco Cafora, Chiara Favero, Francesca Zimetti

Int J Mol Sci· October 2022

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Serum cholesterol loading capacity on macrophages is linked to coronary atherosclerosis and cardiovascular event risk in rheumatoid arthritis.
George Athanasios Karpouzas, Bianca Papotti, Sarah Ormseth, Marcella Palumbo, Elizabeth Hernandez, Francesca Zimetti

RMD Open· September 2022

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HDL metabolism and functions impacting on cell cholesterol homeostasis are specifically altered in patients with abdominal aortic aneurysm.
Maria Pia Adorni, Marcella Palumbo, Cinzia Marchi, Francesca Zimetti, Alice Ossoli

Front Immunol· September 2022

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HDL Cholesterol Efflux and Serum Cholesterol Loading Capacity Alterations Associate to Macrophage Cholesterol Accumulation in FH Patients with Achilles Tendon Xanthoma.
Maria Pia Adorni, Marta Biolo, Francesca Zimetti, Marcella Palumbo, Nicoletta Ronda

Int J Mol Sci· July 2022

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Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation.
Marcella Palumbo, Antonina Giammanco, Francesco Purrello, Chiara Pavanello, Giuliana Mombelli, Francesca Zimetti

Front Mol Biosci· July 2022

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