Publications by authors named "Francesco Miceli"

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The fast-dissociating D antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Francesco Miceli

Br J Pharmacol· November 2025

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Potassium current inactivation as a novel pathomechanism for KCNQ2 developmental and epileptic encephalopathy.
Ingride Luzio Gaspar, Gaetano Terrone, Giusy Carleo, Lidia Carotenuto, Francesco Miceli

Epilepsia· June 2025

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Constitutive opening of the Kv7.2 pore activation gate causes -developmental encephalopathy.
Mario Nappi, Giulio Alberini, Alessandro Berselli, Agnese Roscioni, Maria Virginia Soldovieri, Francesco Miceli

Proc Natl Acad Sci U S A· December 2024

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Assisted Identification, Synthesis, and Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel.
Nunzio Iraci, Lidia Carotenuto, Tania Ciaglia, Giorgio Belperio, Francesca Di Matteo, Francesco Miceli

J Med Chem· June 2024

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Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage.
Camilla Celentano, Lidia Carotenuto, Francesco Miceli, Giusy Carleo, Brunella Corrado

Am J Physiol Cell Physiol· March 2024

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Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment.
Allan Bayat, Stefano Iavarone, Francesco Miceli, Anne V Jakobsen, Katrine M Johannesen

Neurotherapeutics· January 2024

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A new Kchannel-independent mechanism is involved in the antioxidant effect of XE-991 in an in vitro model of glucose metabolism impairment: implications for Alzheimer's disease.
Silvia Piccirillo, Alessandra Preziuso, Salvatore Amoroso, Tiziano Serfilippi, Francesco Miceli

Cell Death Discov· September 2022

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Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity.
Simona Musella, Lidia Carotenuto, Nunzio Iraci, Giulia Baroli, Tania Ciaglia, Francesco Miceli

J Med Chem· August 2022

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KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism.
Francesco Miceli, Charissa Millevert, Maria Virginia Soldovieri, Ilaria Mosca, Paolo Ambrosino

EBioMedicine· July 2022

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Gain of function due to increased opening probability by two pore variants causing developmental and epileptic encephalopathy.
Mario Nappi, Vincenzo Barrese, Lidia Carotenuto, Gaetan Lesca, Audrey Labalme, Francesco Miceli

Proc Natl Acad Sci U S A· April 2022

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Kv7.4 channels regulate potassium permeability in neuronal mitochondria.
Gianluca Paventi, Maria Virginia Soldovieri, Ilenio Servettini, Vincenzo Barrese, Francesco Miceli

Biochem Pharmacol· March 2022

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Distinct epilepsy phenotypes and response to drugs in KCNA1 gain- and loss-of function variants.
Francesco Miceli, Renzo Guerrini, Mario Nappi, Maria Virginia Soldovieri, Elena Cellini

Epilepsia· January 2022

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Generation of an iPSC line (UNINAi001-A) from a girl with neonatal-onset epilepsy and non-syndromic intellectual disability carrying the homozygous KCNQ3 p.PHE534ILEfs*15 variant and of an iPSC line (UNINAi002-A) from a non-carrier, unaffected brother.
Elena Longobardi, Francesco Miceli, Agnese Secondo, Rita Cicatiello, Antonella Izzo

Stem Cell Res· May 2021

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Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology.
Thomas A Jepps, Vincenzo Barrese, Francesco Miceli

Front Physiol· April 2021

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Benign familial infantile epilepsy associated with KCNQ3 mutation: a rare occurrence or an underestimated event?
Rosaria Nardello, Giuseppe Donato Mangano, Francesco Miceli, Antonina Fontana, Ettore Piro

Epileptic Disord· December 2020

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Genotype-phenotype correlations in patients with de novo pathogenic variants.
Federica Malerba, Giulio Alberini, Ganna Balagura, Francesca Marchese, Elisabetta Amadori, Francesco Miceli

Neurol Genet· December 2020

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Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.
Sirio Fiorino, Claudio Gallo, Maddalena Zippi, Sergio Sabbatani, Roberto Manfredi, Francesco Miceli

Aging Clin Exp Res· October 2020

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The Role of Kv7.2 in Neurodevelopment: Insights and Gaps in Our Understanding.
Nina Dirkx, Francesco Miceli, Maurizio Taglialatela, Sarah Weckhuysen

Front Physiol· October 2020

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A Novel Kv7.3 Variant in the Voltage-Sensing S Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and Rescue by β-Hydroxybutyrate.
Francesco Miceli, Lidia Carotenuto, Vincenzo Barrese, Maria Virginia Soldovieri, Erin L Heinzen

Front Physiol· September 2020

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Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction.
Piera Nappi, Francesco Miceli, Maria Virginia Soldovieri, Paolo Ambrosino, Vincenzo Barrese

Pflugers Arch· July 2020

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Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators.
Carmine Ostacolo, Francesco Miceli, Veronica Di Sarno, Piera Nappi, Nunzio Iraci

J Med Chem· January 2020

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Insights into the pathogenesis of ATP1A1-related CMT disease using patient-specific iPSCs.
Fiore Manganelli, Silvia Parisi, Maria Nolano, Francesco Miceli, Stefano Tozza

J Peripher Nerv Syst· December 2019

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Activation of Kv7 Potassium Channels Inhibits Intracellular Ca Increases Triggered By TRPV1-Mediated Pain-Inducing Stimuli in F11 Immortalized Sensory Neurons.
Paolo Ambrosino, Maria Virginia Soldovieri, Erika Di Zazzo, Gianluca Paventi, Fabio Arturo Iannotti, Francesco Miceli

Int J Mol Sci· September 2019

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