Publications by authors named "Francis Combes"

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Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA.
Francis Combes, Frida J Pettersson, Thanh-Huong Bui

Mol Ther Nucleic Acids· December 2025

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Using nucleolytic toxins as restriction enzymes enables new RNA applications.
Ulli Rothweiler, Sigurd Eidem Gundesø, Emma Wu Mikalsen, Steingrim Svenning, Mahavir Singh, Francis Combes

Nucleic Acids Res· October 2024

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Urea supplementation improves mRNA in vitro transcription by decreasing both shorter and longer RNA byproducts.
Combes Francis, Pettersson Frida J, Bui Thanh-Huong, Molska Alicja, Komissarov Artem

RNA Biol· January 2024

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Rapid and scalable detection of synthetic mRNA byproducts using polynucleotide phosphorylase and polythymidine oligonucleotides.
Francis Combes, Thanh-Huong Bui, Frida J Pettersson, Sjoerd Hak

RNA Biol· January 2024

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Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.
Marie J Pauwels, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Francis Combes

Biomaterials· November 2022

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Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators.
Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Francis Combes

J Am Chem Soc· July 2021

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A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system.
Alexandros Marios Sofias, Francis Combes, Steffen Koschmieder, Gert Storm, Twan Lammers

Drug Discov Today· June 2021

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Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs.
Zifu Zhong, Séan McCafferty, Lisa Opsomer, Haixiu Wang, Hanne Huysmans, Francis Combes

Mol Ther· April 2021

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In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation.
Sean Mc Cafferty, Joyca De Temmerman, Tasuku Kitada, Jacob R Becraft, Ron Weiss, Francis Combes

Mol Ther· March 2021

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Corticosteroids and mRNA Vaccines: A Word of Caution.
Zifu Zhong, Francis Combes, Niek N Sanders

Mol Ther· March 2021

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Immune cells as tumor drug delivery vehicles.
Francis Combes, Evelyne Meyer, Niek N Sanders

J Control Release· November 2020

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Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy.
Hui Li, Simon Van Herck, Yongjun Liu, Yanyun Hao, Xiaochu Ding, Francis Combes

ACS Biomater Sci Eng· September 2020

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Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes.
Francis Combes, Alexandros Marios Sofias, Séan Mc Cafferty, Hanne Huysmans, Joyca De Temmerman

Cancers (Basel)· November 2019

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Improving the Repeatability and Efficacy of Intradermal Electroporated Self-Replicating mRNA.
Hanne Huysmans, Joyca De Temmerman, Zifu Zhong, Séan Mc Cafferty, Francis Combes

Mol Ther Nucleic Acids· September 2019

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Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses.
Lutz Nuhn, Stefaan De Koker, Sandra Van Lint, Zifu Zhong, João Portela Catani, Francis Combes

Adv Mater· November 2018

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Off-Target and Tumor-Specific Accumulation of Monocytes, Macrophages and Myeloid-Derived Suppressor Cells after Systemic Injection.
Francis Combes, Séan Mc Cafferty, Evelyne Meyer, Niek N Sanders

Neoplasia· August 2018

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Comparison of the Expression Kinetics and Immunostimulatory Activity of Replicating mRNA, Nonreplicating mRNA, and pDNA after Intradermal Electroporation in Pigs.
Bregje Leyman, Hanne Huysmans, Séan Mc Cafferty, Francis Combes, Eric Cox

Mol Pharm· February 2018

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Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice.
Sofie Denies, Bregje Leyman, Hanne Huysmans, Francis Combes, Séan Mc Cafferty

Cancer Immunol Immunother· December 2017

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