Publications by authors named "Francois Debaene"

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Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM.
Jérôme Castel, Thomas Botzanowski, Ieva Brooks, Alexandre Frechard, Gilbert Bey, François Debaene

Sci Rep· August 2025

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Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residues.
Wataru Asano, Rie Hantani, Toru Uhara, François Debaene, Akihiro Nomura

SLAS Discov· March 2024

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A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.
Hanne Hillen, Aurélie Candi, Bart Vanderhoydonck, Weronika Kowalczyk, Leticia Sansores-Garcia, Francois Debaene

Mol Cancer Ther· January 2024

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The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein-Protein Interface of Homodimeric tRNA-Guanine Transglycosylase.
Andreas Nguyen, Dzung Nguyen, Tran Xuan Phong Nguyen, Maurice Sebastiani, Stefanie Dörr, François Debaene

ACS Chem Biol· November 2020

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A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state.
Gisela Schnapp, Heike Neubauer, Frank H Büttner, Sandra Handschuh, Iain Lingard, Francois Debaene

Commun Chem· June 2020

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Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches.
Guillaume Terral, Thierry Champion, François Debaene, Olivier Colas, Maxime Bourguet

MAbs· July 2018

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Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
Frederik Rainer Ehrmann, Johann Stojko, Alexander Metz, François Debaene, Luzi Jakob Barandun

PLoS One· May 2017

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Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.
Alain Beck, Guillaume Terral, François Debaene, Elsa Wagner-Rousset, Julien Marcoux

Expert Rev Proteomics· October 2016

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What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme Tgt.
Stephan Jakobi, Phong T X Nguyen, François Debaene, Sarah Cianférani, Klaus Reuter

ACS Chem Biol· August 2015

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CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability.
Sergii Kolodych, Oleksandr Koniev, Zoljargal Baatarkhuu, Jean-Yves Bonnefoy, François Debaene

Bioconjug Chem· February 2015

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Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.
Alain Beck, François Debaene, Hélène Diemer, Elsa Wagner-Rousset, Olivier Colas

J Mass Spectrom· February 2015

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Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.
François Debaene, Amandine Boeuf, Elsa Wagner-Rousset, Olivier Colas, Daniel Ayoub

Anal Chem· November 2014

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Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme.
Stephan Jakobi, Tran Xuan Phong Nguyen, François Debaene, Alexander Metz, Sarah Sanglier-Cianférani

Proteins· October 2014

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Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.
Mattia Mori, Alessandro Nucci, Maria Chiara Dasso Lang, Nicolas Humbert, Christian Boudier, Francois Debaene

ACS Chem Biol· September 2014

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Launching spiking ligands into a protein-protein interface: a promising strategy to destabilize and break interface formation in a tRNA modifying enzyme.
Florian Immekus, Luzi Jakob Barandun, Michael Betz, François Debaene, Stéphanie Petiot

ACS Chem Biol· August 2014

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Supramolecular luminescent lanthanide dimers for fluoride sequestering and sensing.
Tao Liu, Aline Nonat, Maryline Beyler, Martín Regueiro-Figueroa, Katia Nchimi Nono, François Debaene

Angew Chem Int Ed Engl· July 2014

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Time resolved native ion-mobility mass spectrometry to monitor dynamics of IgG4 Fab arm exchange and "bispecific" monoclonal antibody formation.
François Debaene, Elsa Wagner-Rousset, Olivier Colas, Daniel Ayoub, Nathalie Corvaïa

Anal Chem· October 2013

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Simultaneous self-assembly of a [2]catenane, a trefoil knot, and a Solomon link from a simple pair of ligands.
Thirumurugan Prakasam, Matteo Lusi, Mourad Elhabiri, Carlos Platas-Iglesias, John-Carl Olsen, François Debaene

Angew Chem Int Ed Engl· September 2013

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Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein.
Mattia Mori, Patrizia Schult-Dietrich, Beata Szafarowicz, Nicolas Humbert, Francois Debaene

Virus Res· November 2012

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A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions.
Thomas Vercruysse, Beata Basta, Wim Dehaen, Nicolas Humbert, Jan Balzarini, François Debaene

Retrovirology· November 2012

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Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger.
Alexandra Cousido-Siah, Daniel Ayoub, Graciela Berberián, Mariana Bollo, Alain Van Dorsselaer, François Debaene

Acta Crystallogr D Biol Crystallogr· September 2012

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Self-assembly of PNA-encoded peptides into microarrays.
Francois Debaene, Nicolas Winssinger

Methods Mol Biol· January 2010

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Self-assembled small-molecule microarrays for protease screening and profiling.
Hugo D Urbina, François Debaene, Bernard Jost, Christine Bole-Feysot, Daniel E Mason

Chembiochem· November 2006

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Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.
Jennifer Harris, Daniel E Mason, Jun Li, Keith W Burdick, Bradley J Backes, François Debaene

Chem Biol· October 2004

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Azidopeptide nucleic acid. An alternative strategy for solid-phase peptide nucleic acid (PNA) synthesis.
François Debaene, Nicolas Winssinger

Org Lett· November 2003

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