Publications by authors named "Fraser Cunningham"

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AI Drug Discovery: Expanding the Horizons of Infectious Disease Therapeutics.
Marta Bon, Fraser Cunningham, Jyoti Chauhan, Brian Lu, Sid Jain

ACS Infect Dis· August 2025

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Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation.
Janine L Gray, Elizabeth V K Ledger, Tiffany Suwatthee, Thomas J Burden, Konstantina Arvaniti, Fraser Cunningham

bioRxiv· August 2025

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Correction: Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
Lee A Armstrong, Sven M Lange, Virginia De Cesare, Stephen P Matthews, Raja Sekhar Nirujogi, Fraser Cunningham

PLoS One· April 2024

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Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
Anna Czarna, Jacek Plewka, Leanid Kresik, Alex Matsuda, Abdulkarim Karim, Fraser Cunningham

Structure· August 2022

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Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies.
Loveleena Bansal, Eva-Maria Nichols, Daniel P Howsmon, Jessica Neisen, Christina M Bessant, Fraser Cunningham

Front Pharmacol· April 2022

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Correction to: Mathematical Modelling of Alternative Pathway of Complement System.
Suruchi Bakshi, Fraser Cunningham, Eva-Maria Nichols, Marta Biedzka-Sarek, Jessica Neisen

Bull Math Biol· December 2021

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Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
Lee A Armstrong, Sven M Lange, Virginia Dee Cesare, Stephen P Matthews, Raja Sekhar Nirujogi, Fraser Cunningham

PLoS One· July 2021

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Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Fraser Cunningham, Jorge Esquivias, Raquel Fernández-Menéndez, Arancha Pérez, Ana Guardia

ACS Infect Dis· May 2020

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Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors.
Olga Balabon, Eleni Pitta, Maciej K Rogacki, Eugenia Meiler, Ruth Casanueva, Fraser Cunningham

J Med Chem· May 2020

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Mathematical Modelling of Alternative Pathway of Complement System.
Suruchi Bakshi, Fraser Cunningham, Eva-Maria Nichols, Marta Biedzka-Sarek, Jessica Neisen

Bull Math Biol· February 2020

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Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.
Maciej K Rogacki, Eleni Pitta, Olga Balabon, Sophie Huss, Eva Maria Lopez-Roman, Fraser Cunningham

J Med Chem· December 2018

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Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.
Glenn A McConkey, Paul T P Bedingfield, David R Burrell, Nicholas C Chambers, Fraser Cunningham

Bioorg Med Chem Lett· August 2017

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Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent.
Henok Asfaw, Katja Laqua, Anna Maria Walkowska, Fraser Cunningham, Maria Santos Martinez-Martinez

PLoS One· April 2017

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Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity.
Eleni Pitta, Olga Balabon, Maciej K Rogacki, Jesús Gómez, Fraser Cunningham

Eur J Med Chem· January 2017

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Repurposing clinically approved cephalosporins for tuberculosis therapy.
Santiago Ramón-García, Rubén González Del Río, Angel Santos Villarejo, Gaye D Sweet, Fraser Cunningham

Sci Rep· September 2016

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Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.
Eleni Pitta, Maciej K Rogacki, Olga Balabon, Sophie Huss, Fraser Cunningham

J Med Chem· July 2016

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Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.
Anita Ordas, Robert-Jan Raterink, Fraser Cunningham, Hans J Jansen, Malgorzata I Wiweger

Antimicrob Agents Chemother· February 2015

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Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.
Sarmad N Mageed, Fraser Cunningham, Alvin Wei Hung, Hernani Leonardo Silvestre, Shijun Wen

Antimicrob Agents Chemother· November 2014

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An in silico structure-based approach to anti-infective drug discovery.
Fraser Cunningham, Martin J McPhillie, A Peter Johnson, Colin W G Fishwick

Parasitology· January 2014

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Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.
Paul T P Bedingfield, Deborah Cowen, Paul Acklam, Fraser Cunningham, Mark R Parsons

J Med Chem· June 2012

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