Publications by authors named "Fred Apple"

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N-Terminal Pro-B-Type Natriuretic Peptide and B-Type Natriuretic Peptide-to-Troponin - Ratios for Differentiating Type 1 From Type 2 Myocardial Infarction: A HIGH-US Substudy.
Muhammad Memon, Robert H Christenson, Gordon Jacobsen, Fred S Apple, Adam J Singer

Crit Pathw Cardiol· December 2025

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Analytical Error of Cardiac Troponin and Impact on the Performance of Accelerated Diagnostic Protocols in Patients with Acute Chest Pain.
Nasir Saeed, Ingar Z Restan, Ole-Thomas Steiro, Hilde L Tjora, Jørund Langørgen, Fred S Apple

Clin Chem· December 2025

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Cardiac Biomarkers for the Prediction, Discrimination, and Risk-Stratification of Type 2 Myocardial Infarction: A Critical Appraisal.
Daniel L Pollmann, Jonathan D Knott, Pedro E P Carvalho, Fred S Apple, Allan S Jaffe

Am J Med· October 2025

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Cardiovascular biomarkers for risk stratification in primary prevention.
Johannes T Neumann, James A de Lemos, Fred S Apple, Darryl P Leong

Eur Heart J· October 2025

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Clinical Performance of a Novel Point-of-Care High-Sensitivity Cardiac Troponin I Assay.
Alan H B Wu, Simon A Mahler, Stacey L House, Saeed A Jortani, Michael H Creer, Fred S Apple

J Appl Lab Med· October 2025

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Diagnostic Accuracy of a Novel 0/1-H Algorithm Using Point-of-Care High-Sensitivity Troponin in the Emergency Department.
Viola I L Thulin, Gard M S Myrmel, Paul O Collinson, Fred S Apple, Kjell Vikenes

Clin Chem· September 2025

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Effectiveness of Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department: A Randomized Controlled Trial.
Viola I L Thulin, Silje M F Jordalen, Gard M S Myrmel, Ole Christian Lekven, Jeyaseelan Krishnapillai, Fred S Apple

Ann Emerg Med· August 2025

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Novel Mindray high sensitivity cardiac troponin I assay for single sample and 0/2-hour rule out of myocardial infarction: MERITnI study.
Kevin G Buda, Yader Sandoval, Stephen W Smith, Barrett Wagner, Karen Schulz, Fred S Apple

Clin Chem Lab Med· July 2025

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Diagnostic performance of Mindray CL1200i high sensitivity cardiac troponin I assay compared to Abbott Alinity cardiac troponin I assay for the diagnosis of type 1 and 2 acute myocardial infarction in females and males: MERITnI study.
Fred S Apple, Kevin G Buda, Barrett P Wagner, Anne Sexter, Yader Sandoval

Clin Chem Lab Med· May 2025

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Design and Analytical Evaluation of Novel Cardiac Troponin Assays Targeting Multiple Forms of the Cardiac Troponin I-Cardiac Troponin T-Troponin C Complex and Fragmentation Forms.
Ling Li, Yuqing Liu, Ivan A Katrukha, Litao Zhang, Xin Shu, Fred S Apple

Clin Chem· March 2025

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Characterization of Cardiac Troponin Fragment Composition Reveals Potential for Differentiating Etiologies of Myocardial Injury.
Ling Li, Yuqing Liu, Ivan A Katrukha, Litao Zhang, Xin Shu, Fred S Apple

Clin Chem· March 2025

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Impact of high-sensitivity cardiac troponin I assay imprecision on the safety of a single-sample rule-out approach for myocardial infarction.
Ziwen Li, Yong Yong Tew, Peter A Kavsak, Kristin M Aakre, Allan S Jaffe, Fred S Apple

Clin Chem Lab Med· February 2025

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Analytical validation of the Mindray CL1200i analyzer high sensitivity cardiac troponin I assay: MERITnI study.
Blanca Fabre-Estremera, Karen Schulz, Alanna Ladd, Anne Sexter, Fred S Apple

Clin Chem Lab Med· November 2024

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Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study.
Betül Toprak, Hugo Solleder, Eleonora Di Carluccio, Jaimi H Greenslade, William A Parsonage, Fred S Apple

Lancet Digit Health· October 2024

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Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h.
Louise Cullen, Jaimi Greenslade, William Parsonage, Laura Stephensen, Stephen W Smith, Fred S Apple

Eur Heart J· July 2024

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Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative.
John W Pickering, Gerard Devlin, Richard Body, Sally Aldous, Allan S Jaffe, Fred S Apple

BMJ Open· June 2024

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Derivation and Validation of Thresholds Using Synthetic Data Methods for Single-Test Screening of Emergency Department Patients with Possible Acute Myocardial Infarction Using a Point-of-Care Troponin Assay.
John W Pickering, Joanna M Young, Peter M George, Antony S Watson, Sally J Aldous, Fred S Apple

J Appl Lab Med· May 2024

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Early Safe Rule Out Using High-Sensitivity Cardiac Troponin: The Role of Sex.
Fred S Apple

J Am Coll Cardiol· May 2024

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External validation of a rapid algorithm using high-sensitivity troponin assay results for evaluating patients with suspected acute myocardial infarction.
Louise Cullen, Jaimi H Greenslade, Laura Stephensen, Isuru Ranasinghe, Niranjan Gaikwad, Fred Apple

Emerg Med J· April 2024

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Large-Scale Scientific Study Led by a Professional Organization during the COVID-19 Pandemic: Operations, Best Practices, and Lessons Learned.
Caitlin R Ondracek, Stacy E F Melanson, Loretta Doan, Karen M Schulz, Stefanie Kleinman, Fred S Apple

J Appl Lab Med· March 2024

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Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification.
Kristin M Aakre, Fred S Apple, Nicolas L Mills, Steven J R Meex, Paul O Collinson

Clin Chem· March 2024

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Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response.
Y Victoria Zhang, Attila Kumanovics, Joesph Wiencek, Stacy E F Melanson, Tanzy Love, Fred S Apple

Viruses· February 2024

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Navigating the Observation Zone: Do Risk Scores Help Stratify Patients With Indeterminate High-Sensitivity Cardiac Troponins?
Nicklaus P Ashburn, James K McCord, Anna C Snavely, Robert H Christenson, Fred S Apple

Circulation· January 2024

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Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design.
Ingrid Viola Lavesson Thulin, Silje Marie Farestveit Jordalen, Ole Christian Lekven, Jeyaseelan Krishnapillai, Ole Thomas Steiro, Fred Apple

Scand Cardiovasc J· December 2023

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Single Troponin Measurement to Rule Out Myocardial Infarction: JACC Review Topic of the Week.
Allan S Jaffe, Richard Body, Nicholas L Mills, Kristin M Aakre, Paul O Collinson, Fred S Apple

J Am Coll Cardiol· July 2023

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