Publications by authors named "Fred Schaper"

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Designing Optimal Experiments to Discriminate Interaction Graph Models.
Sven Thiele, Sandra Heise, Wiebke Hessenkemper, Hannes Bongartz, Melissa Fensky, Fred Schaper

IEEE/ACM Trans Comput Biol Bioinform· July 2025

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Non-canonical STAT3 function reduces REDD1 transcription.
Nadine Köhler, Nicole Wundrack, Svenja Schulz, Florian Bartonitz, Fred Schaper

FEBS J· April 2023

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The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling.
Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Fred Schaper

Cell Commun Signal· September 2021

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Glucocorticoids attenuate interleukin-6-induced c-Fos and Egr1 expression and impair neuritogenesis in PC12 cells.
Hannes Bongartz, Elena Anne Seiß, Jörg Bock, Fred Schaper

J Neurochem· May 2021

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Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling.
Ulrike Billing, Tomasz Jetka, Lukas Nortmann, Nicole Wundrack, Michal Komorowski, Fred Schaper

Commun Biol· April 2020

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The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner.
Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Fred Schaper

Cell Commun Signal· October 2019

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Intragenic regulation of SOCS3 isoforms.
Oliver Klepsch, Lise Sarah Namer, Nadine Köhler, Raymond Kaempfer, Anna Dittrich, Fred Schaper

Cell Commun Signal· June 2019

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Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling.
Heike Reeh, Nadine Rudolph, Ulrike Billing, Henrike Christen, Stefan Streif, Fred Schaper

Cell Commun Signal· May 2019

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Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.
Jamie J L Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, Fred Schaper

Nat Commun· January 2018

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The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.
Hannes Bongartz, Wiebke Hessenkemper, Christian Müller, Melissa Fensky, Johannes Fritsch, Fred Schaper

Cell Signal· July 2017

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Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner.
Jessica Pinno, Hannes Bongartz, Oliver Klepsch, Nicole Wundrack, Valeria Poli, Fred Schaper

Cell Signal· August 2016

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Systems biology of IL-6, IL-12 family cytokines.
Anna Dittrich, Wiebke Hessenkemper, Fred Schaper

Cytokine Growth Factor Rev· October 2015

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Interleukin-6: Biology, signaling and strategies of blockade.
Fred Schaper, Stefan Rose-John

Cytokine Growth Factor Rev· October 2015

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"Family reunion"--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines.
Stefan Rose-John, Jürgen Scheller, Fred Schaper

Cytokine Growth Factor Rev· October 2015

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MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.
Alexandra Wolf, René Eulenfeld, Hannes Bongartz, Wiebke Hessenkemper, Philip C Simister, Fred Schaper

Cell Signal· February 2015

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JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.
Alexandra Wolf, René Eulenfeld, Karoline Gäbler, Catherine Rolvering, Serge Haan, Fred Schaper

JAKSTAT· July 2013

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Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach.
Anna Dittrich, Elmar Siewert, Fred Schaper

Methods Mol Biol· June 2013

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JAK/STAT signalling--an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology.
Mary Ann Blätke, Anna Dittrich, Christian Rohr, Monika Heiner, Fred Schaper

Mol Biosyst· June 2013

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Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia.
Pia J Müller, Kristoffer T G Rigbolt, Dirk Paterok, Jacob Piehler, Jens Vanselow, Fred Schaper

J Proteomics· June 2013

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mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.
Stefan Thiem, Thomas P Pierce, Michelle Palmieri, Tracy L Putoczki, Michael Buchert, Fred Schaper

J Clin Invest· February 2013

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Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling.
Johannes G Bode, Ute Albrecht, Dieter Häussinger, Peter C Heinrich, Fred Schaper

Eur J Cell Biol· November 2012

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Interleukin-6 signalling: more than Jaks and STATs.
René Eulenfeld, Anna Dittrich, Christina Khouri, Pia J Müller, Barbara Mütze, Fred Schaper

Eur J Cell Biol· November 2012

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Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling.
Anna Dittrich, Tom Quaiser, Christina Khouri, Dieter Görtz, Martin Mönnigmann, Fred Schaper

Mol Biosyst· August 2012

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Plasticity and cross-talk of interleukin 6-type cytokines.
Christoph Garbers, Heike M Hermanns, Fred Schaper, Gerhard Müller-Newen, Joachim Grötzinger

Cytokine Growth Factor Rev· June 2012

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Glucagon counteracts interleukin-6-dependent gene expression by redundant action of Epac and PKA.
Christina Khouri, Anna Dittrich, Sara Dutton Sackett, Bernd Denecke, Christian Trautwein, Fred Schaper

Biol Chem· December 2011

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