Publications by authors named "Fred W van Leeuwen"

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Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model.
Inbal Maniv, Mahasen Sarji, Anwar Bdarneh, Alona Feldman, Roi Ankawa, Fred W van Leeuwen

Nat Commun· September 2023

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Correction to: Somatic mutations in neurons during aging and neurodegeneration.
Bert M Verheijen, Marc Vermulst, Fred W van Leeuwen

Acta Neuropathol· September 2020

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Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains.
Bert M Verheijen, Satoru Morimoto, Ryogen Sasaki, Kiyomitsu Oyanagi, Yasumasa Kokubo, Fred W van Leeuwen

J Neuropathol Exp Neurol· August 2020

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The next steps in curing Alzheimer's disease.
Fred W van Leeuwen

Prog Mol Biol Transl Sci· July 2020

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Activation of the Unfolded Protein Response and Proteostasis Disturbance in Parkinsonism-Dementia of Guam.
Bert M Verheijen, Celina Lussier, Cora Müller-Hübers, Ralph M Garruto, Kiyomitsu Oyanagi, Fred W van Leeuwen

J Neuropathol Exp Neurol· January 2020

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Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model.
Bert M Verheijen, Jo A A Stevens, Romina J G Gentier, Christian D van 't Hekke, Daniel L A van den Hove, Fred W van Leeuwen

Neurobiol Aging· December 2018

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Age-related Disturbances in DNA (hydroxy)methylation in APP/PS1 Mice.
Leonidas Chouliaras, Roy Lardenoije, Gunter Kenis, Diego Mastroeni, Patrick R Hof, Fred W van Leeuwen

Transl Neurosci· December 2018

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Mutant ubiquitin reduces Aβ plaques.
Bert M Verheijen, Fred W van Leeuwen

Aging (Albany NY)· October 2018

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Somatic mutations in neurons during aging and neurodegeneration.
Bert M Verheijen, Marc Vermulst, Fred W van Leeuwen

Acta Neuropathol· June 2018

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Dysfunction of Protein Quality Control in Parkinsonism-Dementia Complex of Guam.
Bert M Verheijen, Kiyomitsu Oyanagi, Fred W van Leeuwen

Front Neurol· March 2018

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The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline.
Heidi I L Jacobs, David A Hopkins, Helen C Mayrhofer, Emiliano Bruner, Fred W van Leeuwen

Brain· January 2018

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Commentary: The landscape of transcription errors in eukaryotic cells.
Bert M Verheijen, Fred W van Leeuwen

Front Genet· December 2017

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Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam.
Bert M Verheijen, Tomoyo Hashimoto, Kiyomitsu Oyanagi, Fred W van Leeuwen

Acta Neuropathol Commun· November 2017

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Editorial: Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System.
Ashok N Hegde, Fred W van Leeuwen

Front Mol Neurosci· July 2017

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Selective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum.
Bert M Verheijen, Romina J G Gentier, Denise J H P Hermes, Fred W van Leeuwen, David A Hopkins

Cerebellum· June 2017

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Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice.
Annerieke S R Sierksma, Laurence de Nijs, Govert Hoogland, Tim Vanmierlo, Fred W van Leeuwen

J Alzheimers Dis· December 2016

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Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease.
Romina J Gentier, Fred W van Leeuwen

Front Mol Neurosci· September 2015

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Localization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer's disease.
Romina J G Gentier, Bert M Verheijen, Margherita Zamboni, Maartje M A Stroeken, Denise J H P Hermes, Fred W Van Leeuwen

Front Neuroanat· April 2015

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Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.
Jean-Ha Baek, Eva Schmidt, Nikenza Viceconte, Charlotte Strandgren, Karin Pernold, Fred W Van Leeuwen

Hum Mol Genet· March 2015

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Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin.
Ralf J Braun, Cornelia Sommer, Christine Leibiger, Romina J G Gentier, Verónica I Dumit, Fred W van Leeuwen

Cell Rep· March 2015

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Lectin OS-9 delivers mutant neuroserpin to endoplasmic reticulum associated degradation in familial encephalopathy with neuroserpin inclusion bodies.
Angela Schipanski, Felix Oberhauser, Melanie Neumann, Sascha Lange, Beata Szalay, Fred W van Leeuwen

Neurobiol Aging· October 2014

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Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa.
Shawn W Zimmerman, Young-Joo Yi, Miriam Sutovsky, Fred W van Leeuwen, Gavin Conant

Cell Tissue Res· April 2014

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Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.
Paula van Tijn, Frank J A Dennissen, Romina J G Gentier, Barbara Hobo, Denise Hermes, Fred W Van Leeuwen

Neurochem Int· October 2012

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Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
Martin Irmler, Romina J G Gentier, Frank J A Dennissen, Holger Schulz, Ines Bolle, Fred W Van Leeuwen

Acta Neuropathol· August 2012

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Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
Frank J A Dennissen, Natalia Kholod, Denise J H P Hermes, Nadja Kemmerling, Harry W M Steinbusch, Fred W van Leeuwen

FEBS Lett· August 2011

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