Publications by authors named "Frederic Allain"

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Multiplexed Analysis of Multicomponent Biomolecular Condensates without Any Tag.
Gyula Pálfy, Johannes Schmoll, Maria E Pérez, Fred F Damberger, Yaning Han, Frédéric H-T Allain

J Am Chem Soc· December 2025

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Water-detected NMR allows dynamic observations of repeat-expansion RNA condensates.
Johannes Schmoll, Mihajlo Novakovic, Frédéric H-T Allain

Nat Chem· November 2025

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A highly sensitive protein-RNA cross-linking mass spectrometry workflow with enhanced structural modeling potential.
Chris P Sarnowski, Anna Knörlein, Tebbe de Vries, Michael Götze, Irene Beusch, Frédéric H-T Allain

Nucleic Acids Res· June 2025

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LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels.
Mihajlo Novakovic, Yaning Han, Nina C Kathe, Yinan Ni, Leonidas Emmanouilidis, Frédéric H-T Allain

Nat Commun· May 2025

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High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.
Maartje J Luteijn, Varun Bhaskar, Dominic Trojer, Melanie Schürz, Hicham Mahboubi, Frederic Allain

Nucleic Acids Res· April 2025

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Newton's cradle-like allosteric mechanism explains regulatory RsmE RNA binding.
Esteban Finol, Fred F Damberger, Miroslav Krepl, Timo Flügel, Priscilla Dietrich, Frédéric H-T Allain

Res Sq· April 2025

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Steering research on mRNA splicing in cancer towards clinical translation.
Olga Anczukow, Frédéric H-T Allain, Brittany L Angarola, Douglas L Black, Angela N Brooks

Nat Rev Cancer· December 2024

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The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Frédéric H T Allain

Nat Commun· October 2024

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N-terminal domain of polypyrimidine-tract binding protein is a dynamic folding platform for adaptive RNA recognition.
Fred F Damberger, Miroslav Krepl, Rajika Arora, Irene Beusch, Christophe Maris, Frédéric H-T Allain

Nucleic Acids Res· September 2024

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A solid beta-sheet structure is formed at the surface of FUS droplets during aging.
Leonidas Emmanouilidis, Ettore Bartalucci, Yelena Kan, Mahdiye Ijavi, Maria Escura Pérez, Frédéric H-T Allain

Nat Chem Biol· August 2024

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The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
Florian Malard, Antje C Wolter, Julien Marquevielle, Estelle Morvan, Agathe Ecoutin, Frédéric H T Allain

Nucleic Acids Res· May 2024

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Buffer choice and pH strongly influence phase separation of SARS-CoV-2 nucleocapsid with RNA.
Nina C Kathe, Mihajlo Novakovic, Frédéric H-T Allain

Mol Biol Cell· May 2024

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Initial Primer Synthesis of a DNA Primase Monitored by Real-Time NMR Spectroscopy.
Pengzhi Wu, Johannes Zehnder, Nina Schröder, Pascal E W Blümmel, Loïc Salmon, Frédéric H-T Allain

J Am Chem Soc· April 2024

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Ensemble structure of the N-terminal domain (1-267) of FUS in a biomolecular condensate.
Laura Esteban-Hofer, Leonidas Emmanouilidis, Maxim Yulikov, Frédéric H-T Allain, Gunnar Jeschke

Biophys J· March 2024

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Specific protein-RNA interactions are mostly preserved in biomolecular condensates.
Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Frédéric H-T Allain

Sci Adv· March 2024

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The 100-protein NMR spectra dataset: A resource for biomolecular NMR data analysis.
Piotr Klukowski, Fred F Damberger, Frédéric H-T Allain, Hideo Iwai, Harindranath Kadavath

Sci Data· January 2024

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RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing.
Ahmed Moursy, Antoine Cléry, Stefan Gerhardy, Katharina M Betz, Sanjana Rao, Frédéric H-T Allain

Nat Commun· November 2023

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Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility.
Georg Dorn, Christoph Gmeiner, Tebbe de Vries, Emil Dedic, Mihajlo Novakovic, Frédéric H-T Allain

Nat Commun· October 2023

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Elongated Bacterial Pili as a Versatile Alignment Medium for NMR Spectroscopy.
Sirine Nouri, Julien Boudet, Hiang Dreher-Teo, Frédéric H-T Allain, Rudi Glockshuber

Angew Chem Int Ed Engl· September 2023

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Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns.
Manuela Pérez-Berlanga, Vera I Wiersma, Aurélie Zbinden, Laura De Vos, Ulrich Wagner, Frederic H-T Allain

EMBO J· September 2023

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Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39.
Sébastien Campagne, Daniel Jutzi, Florian Malard, Maja Matoga, Ksenija Romane, Frédéric H-T Allain

Nat Commun· September 2023

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A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2.
Giacomo Padroni, Maria Bikaki, Mihajlo Novakovic, Antje C Wolter, Simon H Rüdisser, Frederic H-T Allain

Nucleic Acids Res· May 2023

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RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.
Markus Blatter, Charlotte Meylan, Antoine Cléry, Roberto Giambruno, Yaroslav Nikolaev, Frédéric H-T Allain

Sci Adv· April 2023

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The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.
Malgorzata M Duszczyk, Harry Wischnewski, Tamara Kazeeva, Rajika Arora, Fionna E Loughlin, Frédéric H-T Allain

Nat Commun· October 2022

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Structural basis for Cas9 off-target activity.
Martin Pacesa, Chun-Han Lin, Antoine Cléry, Aakash Saha, Pablo R Arantes, Frédéric H-T Allain

Cell· October 2022

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