Publications by authors named "Frederic Brocard"

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Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model.
Yaroslav I Molkov, Florent Krust, Russell Jeter, Tommy Stell, Mohammed A Y Mohammed, Frédéric Brocard

Front Cell Neurosci· November 2025

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Functional contribution of astrocytic Kir4.1 channels to spasticity after spinal cord injury.
Tony Barbay, Emilie Pecchi, Jorge Ramirez-Franco, Anton Ivanov, Frédéric Brocard

Brain· October 2025

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Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model.
Yaroslav I Molkov, Florent Krust, Russell Jeter, Tommy Stell, Mohammed A Y Mohammed, Frédéric Brocard

bioRxiv· September 2025

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Calpains at the Crossroads of Spinal Cord Physiology, Plasticity, and Pathology.
Frédéric Brocard, Nejada Dingu

Cells· September 2025

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The SpasT-SCI-T trial protocol: Investigating calpain-mediated sodium channel fragments as biomarkers for traumatic CNS injuries and spasticity prediction.
Guillaume Baucher, Sylvie Liabeuf, Cécile Brocard, Aurélie Ponz, Karine Baumstarck, Frédéric Brocard

PLoS One· May 2025

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Knockdown of calpain1 in lumbar motoneurons reduces spasticity after spinal cord injury in adult rats.
Marjorie Kerzonkuf, Jérémy Verneuil, Cécile Brocard, Nejada Dingu, Virginie Trouplin, Frédéric Brocard

Mol Ther· April 2024

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Effect of size on expression of bistability in mouse spinal motoneurons.
Ronald M Harris-Warrick, Emilie Pecchi, Benoît Drouillas, Frédéric Brocard, Rémi Bos

J Neurophysiol· April 2024

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Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.
Benoît Drouillas, Cécile Brocard, Sébastien Zanella, Rémi Bos, Frédéric Brocard

Cell Rep· September 2023

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A size principle for bistability in mouse spinal motoneurons.
Ronald M Harris-Warrick, Emilie Pecchi, Benoît Drouillas, Frédéric Brocard, Rémi Bos

bioRxiv· September 2023

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Astrocytic Kir4.1 channels regulate locomotion by orchestrating neuronal rhythmicity in the spinal network.
Tony Barbay, Emilie Pecchi, Myriam Ducrocq, Nathalie Rouach, Frédéric Brocard

Glia· May 2023

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Riluzole for treating spasticity in patients with chronic traumatic spinal cord injury: Study protocol in the phase ib/iib adaptive multicenter randomized controlled RILUSCI trial.
Maëva Cotinat, Isabelle Boquet, Moreno Ursino, Cécile Brocard, Elisabeth Jouve, Frédéric Brocard

PLoS One· January 2023

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Altered action potential waveform and shorter axonal initial segment in hiPSC-derived motor neurons with mutations in VRK1.
Rémi Bos, Khalil Rihan, Patrice Quintana, Lara El-Bazzal, Nathalie Bernard-Marissal, Frédéric Brocard

Neurobiol Dis· March 2022

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Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice.
Rémi Bos, Benoît Drouillas, Mouloud Bouhadfane, Emilie Pecchi, Virginie Trouplin, Frédéric Brocard

Nat Commun· November 2021

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The M-current works in tandem with the persistent sodium current to set the speed of locomotion.
Jérémy Verneuil, Cécile Brocard, Virginie Trouplin, Laurent Villard, Julie Peyronnet-Roux, Frédéric Brocard

PLoS Biol· November 2020

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Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis.
Guillem Mòdol-Caballero, Belén García-Lareu, Sergi Verdés, Lorena Ariza, Irene Sánchez-Brualla, Frédéric Brocard

Neurotherapeutics· July 2020

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Alteration of glycinergic receptor expression in lumbar spinal motoneurons is involved in the mechanisms underlying spasticity after spinal cord injury.
Karina Sadlaoud, Loubna Khalki, Fredéric Brocard, Laurent Vinay, Pascale Boulenguez

J Chem Neuroanat· July 2020

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Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity.
Vanessa Plantier, Irene Sanchez-Brualla, Nejada Dingu, Cécile Brocard, Sylvie Liabeuf, Frédéric Brocard

Elife· December 2019

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Activation of 5-HT Receptors Restores KCC2 Function and Reduces Neuropathic Pain after Spinal Cord Injury.
Irene Sánchez-Brualla, Pascale Boulenguez, Cécile Brocard, Sylvie Liabeuf, Annelise Viallat-Lieutaud, Frédéric Brocard

Neuroscience· September 2018

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[Calpain as a new therapeutic target for treating spasticity after a spinal cord injury].
Vanessa Plantier, Frédéric Brocard

Med Sci (Paris)· June 2018

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Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.
Rémi Bos, Ronald M Harris-Warrick, Cécile Brocard, Liliia E Demianenko, Marin Manuel, Frédéric Brocard

Cell Rep· March 2018

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Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury.
Sylvie Liabeuf, Laetitia Stuhl-Gourmand, Florian Gackière, Renzo Mancuso, Irene Sanchez Brualla, Frédéric Brocard

J Neurotrauma· December 2017

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Cleavage of Na(+) channels by calpain increases persistent Na(+) current and promotes spasticity after spinal cord injury.
Cécile Brocard, Vanessa Plantier, Pascale Boulenguez, Sylvie Liabeuf, Mouloud Bouhadfane, Frédéric Brocard

Nat Med· April 2016

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KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
Yves Cazals, Michelle Bévengut, Sébastien Zanella, Frédéric Brocard, Jacques Barhanin

Nat Commun· November 2015

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Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin.
Mouloud Bouhadfane, Attila Kaszás, Balázs Rózsa, Ronald M Harris-Warrick, Laurent Vinay, Frédéric Brocard

Elife· March 2015

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Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats.
Mouloud Bouhadfane, Sabrina Tazerart, Aziz Moqrich, Laurent Vinay, Frédéric Brocard

J Neurosci· September 2013

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