Publications by authors named "Frederic Checler"

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Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.
De-Hua Chui, Hiroshi Tanahashi, Kazuharu Ozawa, Sachiya Ikeda, Frédéric Checler

Nat Med· August 2025

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Hampered AMPK-ULK1 cascade in Alzheimer's disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin.
Arnaud Mary, Samantha Barale, Fanny Eysert, Audrey Valverde, Sandra Lacas-Gervais, Frédéric Checler

Alzheimers Res Ther· June 2025

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α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance.
Eric Duplan, Aurore Bernardin, Thomas Goiran, Nathalie Leroudier, Mathew Casimiro, Frédéric Checler

Cell Death Dis· March 2025

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TFinder: A Python Web Tool for Predicting Transcription Factor Binding Sites.
Julien Minniti, Frédéric Checler, Eric Duplan, Cristine Alves da Costa

J Mol Biol· February 2025

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Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion.
Inger Lauritzen, Anaïs Bini, Anaïs Bécot, Anne-Sophie Gay, Céline Badot, Frédéric Checler

J Extracell Vesicles· January 2025

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Suppression of MT5-MMP Reveals Early Modulation of Alzheimer's Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice.
Dominika Pilat, Jean-Michel Paumier, Laurence Louis, Christine Manrique, Laura García-González, Frédéric Checler

Biomolecules· December 2024

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Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17.
Guillaume Dolla, Sarah Nicolas, Ligia Ramos Dos Santos, Alexandre Bourgeois, Raphaëlle Pardossi-Piquard, Frédéric Checler

J Biol Chem· July 2024

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Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks.
Fanny Eysert, Paula-Fernanda Kinoshita, Julien Lagarde, Sandra Lacas-Gervais, Laura Xicota, Frédéric Checler

Acta Neuropathol Commun· June 2024

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The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.
Loan Vaillant-Beuchot, Fanny Eysert, Blandine Duval, Paula Fernanda Kinoshita, Raphaëlle Pardossi-Piquard, Frédéric Checler

Cell Death Dis· May 2024

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Potentially Pathogenic Mutations Observed in Autosomal-Dominant Cases of Alzheimer's Disease Do Not Modulate APP Physiopathological Processing.
Charlotte Bauer, Eric Duplan, Peter Saint-George-Hyslop, Frédéric Checler

Cells· December 2023

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Correction to: Intraneuronal aggregation of the β‑CTF fragment of APP (C99) induces Aβ‑independent lysosomal-autophagic pathology.
Inger Lauritzen, Raphaëlle Pardossi-Piquard, Alexandre Bourgeois, Sophie Pagnotta, Maria-Grazia Biferi, Frederic Checler

Acta Neuropathol· October 2023

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The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production.
Elissa Afram, Inger Lauritzen, Alexandre Bourgeois, Wejdane El Manaa, Eric Duplan, Frederic Checler

Cell Mol Life Sci· March 2023

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Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches.
Arnaud Mary, Fanny Eysert, Frédéric Checler, Mounia Chami

Mol Psychiatry· January 2023

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Aminopeptidase A and dipeptidyl peptidase 4: a pathogenic duo in Alzheimer's disease?
Frédéric Checler, Audrey Valverde

Neural Regen Res· October 2022

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Parkin as a Molecular Bridge Linking Alzheimer's and Parkinson's Diseases?
Frédéric Checler, Cristine Alves da Costa

Biomolecules· April 2022

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Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models.
Lila Rouland, Eric Duplan, Lígia Ramos Dos Santos, Aurore Bernardin, Karen S Katula, Frédéric Checler

Theranostics· February 2022

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Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.
Wejdane El Manaa, Eric Duplan, Thomas Goiran, Inger Lauritzen, Loan Vaillant Beuchot, Frédéric Checler

Autophagy· December 2021

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Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, AnaÑ—s-Camille Vreulx, Amandine Flaig

Mol Psychiatry· October 2021

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[Mitochondrial dysfunction and mitophagy failure in Alzheimer's disease].
Arnaud Mary, Loan Vaillant-Beuchot, Frédéric Checler, Mounia Chami

Med Sci (Paris)· October 2021

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Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains.
Audrey Valverde, Julie Dunys, Thomas Lorivel, Delphine Debayle, Anne-Sophie Gay, Frédéric Checler

J Biol Chem· August 2021

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Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
Frédéric Checler, Elissa Afram, Raphaëlle Pardossi-Piquard, Inger Lauritzen

J Biol Chem· July 2021

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MT5-MMP controls APP and β-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer's disease.
Laura García-González, Jean-Michel Paumier, Laurence Louis, Dominika Pilat, Anne Bernard, Frédéric Checler

FASEB J· July 2021

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Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.
Audrey Valverde, Julie Dunys, Thomas Lorivel, Delphine Debayle, Anne-Sophie Gay, Frédéric Checler

Acta Neuropathol· June 2021

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Frédéric Checler

Autophagy· January 2021

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Pyk2 overexpression in postsynaptic neurons blocks amyloid β-induced synaptotoxicity in microfluidic co-cultures.
Devrim Kilinc, Anaïs-Camille Vreulx, Tiago Mendes, Amandine Flaig, Diego Marques-Coelho, Frédéric Checler

Brain Commun· August 2020

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