Publications by authors named "Frederic D Bushman"

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Pooled CAR-T screening in pig-tailed macaques identifies designs with enhanced proliferation, trafficking, and persistence.
Lucy H Maynard, Eric J Cavanaugh, Haiying Zhu, Carly E Starke, Sarah M Doherty, Frederic D Bushman

Blood· November 2025

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Baseline intestinal microbiota composition influences response to a real-world dietary fiber intervention.
Fabiana A Hoffmann Sardá, Eliana B Giuntini, Aline Oliveira, Gabriela S Souza, Samira B R Prado, Frederic D Bushman

NPJ Biofilms Microbiomes· November 2025

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Human gut prophage landscape identifies a prophage-mediated fucosylation mechanism alleviating colitis.
Hongyan Gao, Yating Wang, Yulin Zhao, Xianyue Jiao, Zihan Guo, Frederic D Bushman

Nat Commun· November 2025

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Lung transplant for CF: Low lung bacterial burden and immune mediators in year one associate with clad development.
Samantha A Whiteside, John E McGinniss, Rebecca A Deek, Carter Merenstein, Noel Britton, Frederic D Bushman

J Cyst Fibros· October 2025

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Optimizing methods for virome analysis based on studies of a synthetic viral community.
Jiayi Duan, Andrew D Marques, Matthew Hogenauer, Young Hwang, Yanjia Zhang, Frederic D Bushman

bioRxiv· October 2025

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Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors.
Saira Montermoso, Grant Eilers, Audrey Allen, Robert Sharp, Young Hwang, Frederic D Bushman

J Mol Biol· September 2025

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Small molecule inhibition of SUMOylation increases expression from AAV vectors both during and after initial transduction in mice.
Maria C Seleme, Aradhana Kasimsetty, Young Hwang, Carole Lee, Aoife M Roche, Frederic D Bushman

Mol Ther· August 2025

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An integrated enzymatic and computational pipeline for quantifying off-target base-editing.
Alexander G McFarland, Soon-Keat Ooi, Davin Tafuri, Elahe Kamali, Natalie Cooper, Frederic D Bushman

bioRxiv· August 2025

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Structures of Nucleotide-Bound Redondovirus Rep Protein Link Conformation and Function.
Saira Montermoso, Kushol Gupta, Ruth Anne Pumroy, Vera Moiseenkova-Bell, Frederic D Bushman

bioRxiv· August 2025

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Lentiviral gene therapy with reduced-intensity conditioning for sickle cell disease: a phase 1/2 trial.
Michael Grimley, Stella M Davies, Archana Shrestha, Amy Shova, Monika Asnani, Frederic D Bushman

Nat Med· July 2025

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Antigenic Characterization of H1N1 Influenza Viruses That Circulated During the 2019-2020 Season in Philadelphia, Pennsylvania.
Lydia M Mendoza, Elizabeth M Anderson, Ashley Sobel Leonard, Alexander G McFarland, Jordan T Ort, Frederic D Bushman

Influenza Other Respir Viruses· June 2025

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Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use.
Kayla Barekat, Soumita Ghosh, Christin Herrmann, Karl Keat, Charles-Antoine Assenmacher, Frederic D Bushman

bioRxiv· May 2025

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Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice.
Lev Litichevskiy, Maya Considine, Jasleen Gill, Vasuprada Shandar, Timothy O Cox, Frederic D Bushman

Nat Microbiol· May 2025

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Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies.
Julie K Jadlowsky, Elizabeth O Hexner, Amy Marshall, Stephan A Grupp, Noelle V Frey, Frederic D Bushman

Nat Med· April 2025

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Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease.
Steicy Sobrino, Laure Joseph, Elisa Magrin, Anne Chalumeau, Nicolas Hebert, Frederic D Bushman

Nat Commun· April 2025

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Virolithopanspermia: Might viruses be transported in rocks through space?
Frederic D Bushman

PLoS Pathog· March 2025

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CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in .
Karlo Perica, Nayan Jain, Michael Scordo, Ruchi Patel, Ozgur Can Eren, Frederic D Bushman

N Engl J Med· February 2025

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Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia.
Richard A Voit, Xiaotian Liao, Alexis Caulier, Mateusz Antoszewski, Blake Cohen, Frederic D Bushman

Cell Stem Cell· January 2025

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Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15.
Gengwen Tian, Amy N Courtney, Hangjin Yu, Saleh Bhar, Xin Xu, Frederic D Bushman

J Immunother Cancer· January 2025

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Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History.
Mary Eapen, Lynn M Malec, Myriam A Armant, Bryon D Johnson, Qizhen Shi, Frederic D Bushman

N Engl J Med· January 2025

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Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021-2024.
Andrew D Marques, Matthew Hogenauer, Natalie Bauer, Michelle Gibison, Beatrice DeMarco, Frederic D Bushman

PLoS Pathog· January 2025

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Modulation of AAV transduction and integration targeting by topoisomerase poisons.
Aradhana Kasimsetty, Young Hwang, John K Everett, Alexander G McFarland, Sonja A Zolnoski, Frederic D Bushman

Mol Ther Methods Clin Dev· December 2024

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Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs.
Soumita Ghosh, Nick Lahens, Kayla Barekat, Soon-Yew Tang, Katherine N Theken, Frederic D Bushman

bioRxiv· December 2024

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Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors.
Scott E James, Sophia Chen, Brandon D Ng, Jacob S Fischman, Lorenz Jahn, Frederic D Bushman

Nat Biomed Eng· December 2024

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TET2 regulates early and late transitions in exhausted CD8 T cell differentiation and limits CAR T cell function.
Alexander J Dimitri, Amy E Baxter, Gregory M Chen, Caitlin R Hopkins, Geoffrey T Rouin, Frederic D Bushman

Sci Adv· November 2024

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