Publications by authors named "Frederic Donche"

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Philip A Harris, Nicolas Faucher, Nicolas George, Patrick M Eidam, Bryan W King, Frederic Donche

J Med Chem· May 2019

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Discovery of Pyridones As Oral AMPK Direct Activators.
Olivier Mirguet, Stéphane Sautet, Catherine-Anne Clément, Jérôme Toum, Frédéric Donche

ACS Med Chem Lett· July 2013

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From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.
Olivier Mirguet, Yann Lamotte, Frédéric Donche, Jérôme Toum, Françoise Gellibert

Bioorg Med Chem Lett· April 2012

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Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).
Jonathan Seal, Yann Lamotte, Frédéric Donche, Anne Bouillot, Olivier Mirguet

Bioorg Med Chem Lett· April 2012

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Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity.
Marie-Hélène Fouchet, Frédéric Donche, Christelle Martin, Anne Bouillot, Christophe Junot

Bioorg Med Chem· June 2008

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Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
Michael L Sierra, Véronique Beneton, Anne-Bénédict Boullay, Thierry Boyer, Andrew G Brewster, Frédéric Donche

J Med Chem· February 2007

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