Publications by authors named "Frederic Simonin"

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GPRASP1 deletion in mice abrogates adverse side effects associated with chronic stimulation of Beta2-adrenoceptor.
Alaa Abu-Helo, François Daubeuf, Thibaud Tranchant, Christine Lehalle, Khadija Elhabazi, Frédéric Simonin

Biomed Pharmacother· June 2025

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Multitarget μ-Opioid Receptor Agonists─Neuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects.
Jolien De Neve, Khadija Elhabazi, Simon Gonzalez, Claire Herby, Séverine Schneider, Frédéric Simonin

J Med Chem· May 2024

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Characterization of anti-GASP motif antibodies that inhibit the interaction between GPRASP1 and G protein-coupled receptors.
Gabrielle Zeder-Lutz, Olivier Bornert, Rosine Fellmann-Clauss, Adeline Knittel-Obrecht, Thibaud Tranchant, Frédéric Simonin

Anal Biochem· March 2023

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Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization.
Manon Gerum, Frédéric Simonin

Pharmacol Ther· May 2022

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GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners.
Juliette Kaeffer, Gabrielle Zeder-Lutz, Frédéric Simonin, Sandra Lecat

Curr Top Med Chem· July 2021

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Identification of an -acylated-Arg-Leu-NH Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia.
Raphaëlle Quillet, Séverine Schneider, Valérie Utard, Armand Drieu la Rochelle, Khadija Elhabazi, Frédéric Simonin

J Med Chem· June 2021

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Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.
Jolien De Neve, Thomas M A Barlow, Dirk Tourwé, Frédéric Bihel, Frédéric Simonin

RSC Med Chem· June 2021

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Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia.
Hassan Hammoud, Khadija Elhabazi, Raphäelle Quillet, Isabelle Bertin, Valérie Utard, Frédéric Simonin

ACS Chem Neurosci· November 2018

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A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.
Armand Drieu la Rochelle, Karel Guillemyn, Maria Dumitrascuta, Charlotte Martin, Valérie Utard, Frédéric Simonin

Pain· September 2018

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[The neuropeptide FF: a signal for M1 to M2 type switching in macrophages from the adipose tissue].
Raphaëlle Quillet, Frédéric Simonin

Med Sci (Paris)· January 2018

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Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.
Syed F Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Frédéric Simonin

J Clin Invest· September 2017

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Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.
Laurie-Anne Roeckel, Valérie Utard, David Reiss, Jinane Mouheiche, Hervé Maurin, Frédéric Simonin

Sci Rep· September 2017

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Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.
Syed F Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Frédéric Simonin

J Clin Invest· June 2017

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RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
Khadija Elhabazi, Jean-Paul Humbert, Isabelle Bertin, Raphaelle Quillet, Valérie Utard, Frédéric Simonin

Neuropharmacology· May 2017

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Opioid-induced hyperalgesia: Cellular and molecular mechanisms.
Laurie-Anne Roeckel, Glenn-Marie Le Coz, Claire Gavériaux-Ruff, Frédéric Simonin

Neuroscience· December 2016

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Development of Dipeptidic hGPR54 Agonists.
Christelle Doebelin, Isabelle Bertin, Séverine Schneider, Martine Schmitt, Jean-Jacques Bourguignon, Frédéric Simonin

ChemMedChem· October 2016

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RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions.
Raphaëlle Quillet, Safia Ayachi, Frédéric Bihel, Khadija Elhabazi, Brigitte Ilien, Frédéric Simonin

Pharmacol Ther· April 2016

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Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.
Karel Guillemyn, Joanna Starnowska, Camille Lagard, Jolanta Dyniewicz, Ewelina Rojewska, Frédéric Simonin

J Med Chem· April 2016

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Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
Laurent Rouméas, Jean-Paul Humbert, Séverine Schneider, Christelle Doebelin, Isabelle Bertin, Frédéric Simonin

Peptides· September 2015

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Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
Jeanelle Portelli, Alfred Meurs, Frederic Bihel, Hassan Hammoud, Martine Schmitt, Frederic Simonin

Neuropharmacology· August 2015

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Rapid and scalable synthesis of innovative unnatural α,β or γ-amino acids functionalized with tertiary amines on their side-chains.
Séverine Schneider, Hussein Ftouni, Songlin Niu, Martine Schmitt, Frédéric Simonin

Org Biomol Chem· July 2015

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Development of a peptidomimetic antagonist of neuropeptide FF receptors for the prevention of opioid-induced hyperalgesia.
Frédéric Bihel, Jean-Paul Humbert, Séverine Schneider, Isabelle Bertin, Patrick Wagner, Frédéric Simonin

ACS Chem Neurosci· March 2015

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Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors.
Ine Buffel, Alfred Meurs, Jeanelle Portelli, Robrecht Raedt, Veerle De Herdt, Frederic Simonin

Epilepsia· March 2015

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Involvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in Rodents.
Safia Ayachi, Frédéric Simonin

Front Endocrinol (Lausanne)· October 2014

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Assessment of morphine-induced hyperalgesia and analgesic tolerance in mice using thermal and mechanical nociceptive modalities.
Khadija Elhabazi, Safia Ayachi, Brigitte Ilien, Frédéric Simonin

J Vis Exp· July 2014

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