Publications by authors named "Frederick Buckner"

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A novel methionyl-tRNA synthetase inhibitor targeting gram-positive bacterial pathogens.
Nora M R Molasky, Zhongsheng Zhang, J Robert Gillespie, John Domagala, Dawn Reyna, Frederick S Buckner

Antimicrob Agents Chemother· December 2024

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Descriptive and molecular epidemiology of leishmaniasis diagnosed from clinical samples in the United States, 2021-2022.
Thao T Truong, Karissa Crawford, Ichih Wang-McGuire, Kendal Jensen, Aisha Mushtaq, Frederick S Buckner

Microbiol Spectr· October 2024

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Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads.
Michael H Gelb, Frederick S Buckner

ACS Infect Dis· July 2021

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Spontaneous Selection of Drug Resistance in a Calf Model of Infection.
Muhammad M Hasan, Erin E Stebbins, Robert K M Choy, J Robert Gillespie, Eugenio L de Hostos, Frederick S Buckner

Antimicrob Agents Chemother· May 2021

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Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis.
Sheridan Joseph, Timothy J Whitman, Frederick S Buckner, Anna L Cogen

Am J Trop Med Hyg· May 2021

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Synthesis and Structure-Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases.
Daniel G Silva, Anna Junker, Shaiani M G de Melo, Fernando Fumagalli, J Robert Gillespie, Frederick S Buckner

ChemMedChem· March 2021

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The Tryp and the Pendulum.
Frederick S Buckner

EBioMedicine· February 2021

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Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington.
Frederick S Buckner, Denise J McCulloch, Vidya Atluri, Michela Blain, Sarah A McGuffin

Clin Infect Dis· November 2020

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Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against .
Zhongsheng Zhang, Ximena Barros-Álvarez, J Robert Gillespie, Ranae M Ranade, Wenlin Huang, Frederick S Buckner

RSC Med Chem· August 2020

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Hydroxychloroquine for Treatment of SARS-CoV-2 Infection? Improving Our Confidence in a Model-Based Approach to Dose Selection.
Samuel L M Arnold, Frederick Buckner

Clin Transl Sci· July 2020

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Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.
Samantha A Michaels, Han-Wei Shih, Bailin Zhang, Edelmar D Navaluna, Zhongsheng Zhang, Frederick S Buckner

J Antimicrob Chemother· May 2020

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Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach.
Frederick S Buckner, Andriy Buchynskyy, Pendem Nagendar, Donald A Patrick, J Robert Gillespie

Trop Med Infect Dis· February 2020

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Bioactivity of Farnesyltransferase Inhibitors Against and .
Alexandra Probst, Thi N Nguyen, Nelly El-Sakkary, Danielle Skinner, Brian M Suzuki, Frederick S Buckner

Front Cell Infect Microbiol· January 2020

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A new chemotype with promise against Trypanosoma cruzi.
Xiaofang Wang, Monica Cal, Marcel Kaiser, Frederick S Buckner, Galina I Lepesheva

Bioorg Med Chem Lett· January 2020

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Setting Our Sights on Infectious Diseases.
Manu De Rycker, David Horn, Bree Aldridge, Richard K Amewu, Clifton E Barry, Frederick S Buckner

ACS Infect Dis· January 2020

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A 71-year-old man with recurrent pulmonary mycobacterial avium complex infections and lymphopenia.
Taha Al-Shaikhly, Frederick S Buckner, Matthew C Altman, Hans D Ochs, Andrew G Ayars

Allergy Asthma Proc· January 2020

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Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Infection.
Frederick S Buckner, Ranae M Ranade, J Robert Gillespie, Sayaka Shibata, Matthew A Hulverson

Antimicrob Agents Chemother· April 2019

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Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis.
Pendem Nagendar, J Robert Gillespie, Zackary M Herbst, Ranae M Ranade, Nora M R Molasky, Frederick S Buckner

ACS Med Chem Lett· January 2019

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The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Ximena Barros-Álvarez, Stewart Turley, Ranae M Ranade, J Robert Gillespie, Nicole A Duster, Frederick S Buckner

Acta Crystallogr F Struct Biol Commun· April 2018

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Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Omeed Faghih, Zhongsheng Zhang, Ranae M Ranade, J Robert Gillespie, Sharon A Creason, Frederick S Buckner

Antimicrob Agents Chemother· November 2017

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1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti- Agents: SAR and in Vivo Efficacy.
Andriy Buchynskyy, J Robert Gillespie, Zackary M Herbst, Ranae M Ranade, Frederick S Buckner

ACS Med Chem Lett· August 2017

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Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.
Ximena Barros-Álvarez, Keshia M Kerchner, Cho Yeow Koh, Stewart Turley, Els Pardon, Frederick S Buckner

Biochimie· July 2017

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New Class of Antitrypanosomal Agents Based on Imidazopyridines.
Daniel G Silva, J Robert Gillespie, Ranae M Ranade, Zackary M Herbst, Uyen T T Nguyen, Frederick S Buckner

ACS Med Chem Lett· July 2017

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Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Wenlin Huang, Zhongsheng Zhang, Ranae M Ranade, J Robert Gillespie, Ximena Barros-Álvarez, Frederick S Buckner

Bioorg Med Chem Lett· June 2017

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Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Andriy Buchynskyy, J Robert Gillespie, Matthew A Hulverson, Joshua McQueen, Sharon A Creason, Frederick S Buckner

Bioorg Med Chem· March 2017

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