Publications by authors named "Fukui Shen"

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Targeting RPS16 with cinnamaldehyde to suppress cervical cancer: inhibition of the PI3K/AKT pathway and degradation of HPV E6 and E7 proteins.
Shulipan Mulati, Fukui Shen, Ziruo Talihati, Yuqing Zhang, Hao Huang

Biochem Pharmacol· August 2025

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Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion.
Kaixin Liu, Chuanjing Cheng, Jin Yan, Fuyun Chi, Wenshuang Wang, Fukui Shen

Phytomedicine· March 2025

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Ligustilide improves functional constipation by non-covalently activating TRPA1 in colon tissue.
Kaixue Zhang, Guoqing Luan, Wenjuan Liu, Fukui Shen, Min Jiang

J Ethnopharmacol· February 2025

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Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1.
Weiyi Zhang, Wei Lei, Fukui Shen, Mukuo Wang, Linlin Li

Phytother Res· October 2024

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Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury.
Kaixue Zhang, Wenjuan Liu, Fukui Shen, Guoqing Luan, Yanqi Han

J Ethnopharmacol· August 2024

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Sinapine targeting PLCβ3 EF hands disrupts Gαq-PLCβ3 interaction and ameliorates cardiovascular diseases.
Simeng Chu, Fukui Shen, Wenjuan Liu, Jin Zhang, Xiaoying Wang

Phytomedicine· April 2024

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Catalpolaglycone disrupts mitochondrial thermogenesis by specifically binding to a conserved lysine residue of UCP2 on the proton leak tunnel.
Fukui Shen, Wen Yang, Guoqing Luan, Jiamin Peng, Zhenqiang Li

Phytomedicine· March 2024

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Ginsenoside CK targeting KEAP1-DGR/Kelch domain disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage.
Chuanjing Cheng, Jinling Zhang, Kaixin Liu, Yanyan Xu, Fukui Shen

Phytomedicine· October 2023

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Ligustilide covalently binds to Cys129 of HMGCS1 to ameliorate dyslipidemia.
Kaixue Zhang, Fukui Shen, Wei Lei, Yanqi Han, Xiaoyao Ma

Biomed Pharmacother· October 2023

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Evaluating the Anti-Melanoma Effects and Toxicity of Cinnamaldehyde Analogues.
Rongsong Jiang, Fukui Shen, Miaomiao Zhang, Shulipan Mulati, Jinfeng Wang

Molecules· October 2023

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Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain.
Lin Niu, Yu-Jie Lu, Xing-Wang Zu, Wen Yang, Fu-Kui Shen

Phytother Res· September 2023

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Astragaloside IV targets PRDX6, inhibits the activation of RAC subunit in NADPH oxidase 2 for oxidative damage.
Chuanjing Cheng, Kaixin Liu, Fukui Shen, Jinling Zhang, Yang Xie

Phytomedicine· June 2023

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Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3-SARA interaction.
Yu-Jie Lu, Lin Niu, Fu-Kui Shen, Wen Yang, Yang Xie

Phytother Res· February 2023

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Cinnamaldehyde Regulates the Generation of γ-aminobutyric Acid to Exert Sedation via Irreversible Inhibition of ENO1 in the Cerebellar Granular Layer.
Xiaoyao Ma, Kaixin Liu, Yiman Han, Yongping Bai, Fukui Shen

Mol Nutr Food Res· June 2022

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CaMKII, that binds with ligustilide, as a potential drug target of Suxiao jiuxin pill, a traditional Chinese medicine to dilate thoracic aorta.
Yujie Lu, Jie Ji, Simeng Chu, Fukui Shen, Wen Yang

Clin Transl Med· June 2022

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Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle.
Lin Niu, Jie Wang, Fukui Shen, Jie Gao, Min Jiang

J Ethnopharmacol· May 2022

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Okicamelliaside targets the N-terminal chaperone pocket of HSP90 disrupts the chaperone protein interaction of HSP90-CDC37 and exerts antitumor activity.
Chuan-Jing Cheng, Kai-Xin Liu, Man Zhang, Fu-Kui Shen, Li-Li Ye

Acta Pharmacol Sin· April 2022

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A novel mode of action for COX-2 inhibition: Targeting ATPase domain of HSP90 induces ubiquitin degradation of new client protein COX-2.
Man Zhang, Jing Cui, Fukui Shen, Lili Ye, Chuanjing Cheng

Clin Transl Med· January 2022

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Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or in Mice via Regulating the Expression and Phosphorylation of AKT.
Man Zhang, Lili Ye, Chuanjing Cheng, Fukui Shen, Lin Niu

Nutrients· December 2021

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Small-Molecule Fluorogenic Probe for the Detection of Mitochondrial Temperature .
Fukui Shen, Wen Yang, Jing Cui, Yuanyuan Hou, Gang Bai

Anal Chem· October 2021

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Cinnamaldehyde changes the dynamic balance of glucose metabolism by targeting ENO1.
Weiyi Zhang, Jie Gao, Fukui Shen, Xiaoyao Ma, Zhihua Wang

Life Sci· October 2020

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Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy.
Man Zhang, Lili Ye, Hao Huang, Dandan Cheng, Kaixin Liu, Fukui Shen

J Nanobiotechnology· October 2020

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Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1.
Chuanjing Cheng, Fukui Shen, Guoyu Ding, Aina Liu, Simeng Chu

Mol Nutr Food Res· May 2020

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Genipin, a natural AKT inhibitor, targets the PH domain to affect downstream signaling and alleviates inflammation.
Yanting Jiao, Fukui Shen, Zhihua Wang, Lili Ye, Man Zhang

Biochem Pharmacol· December 2019

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Micro-PET Imaging Demonstrates 3--β-D-Glucopyranosyl Platycodigenin as an Effective Metabolite Affects Permeability of Cell Membrane and Improves Dosimetry of [F]-Phillygenin in Lung Tissue.
Fukui Shen, Wenbo Wu, Man Zhang, Xiaoyao Ma, Qingxin Cui

Front Pharmacol· September 2019

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