Publications by authors named "Gagan D Flora"

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The mitochondrial calcium uniporter regulates calcium dynamics to drive platelet function, bioenergetics, and thrombosis.
Madankumar Ghatge, Gagan D Flora, Rakesh B Patel, Manasa K Nayak, Mariia Kumskova

J Thromb Haemost· November 2025

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Platelet defects in patients and mice with Ehlers-Danlos syndrome.
Mariia Kumskova, Gagan D Flora, Manasa K Nayak, Ivan Budnik, Aditi Jain

Blood· November 2025

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Pyruvate kinase M2 promotes venous thrombosis by enhancing SNAP23-mediated platelet exocytosis and consequent NETosis.
Manasa K Nayak, Gagan D Flora, Ivan Budnik, Tarun Barbhuyan, Rakesh B Patel

Blood Adv· October 2025

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Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice.
Gagan D Flora, Madankumar Ghatge, Manasa K Nayak, Tarun Barbhuyan, Mariia Kumskova

Blood Adv· August 2024

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Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI-Stimulated Human Platelets-Brief Report.
Madankumar Ghatge, Gagan D Flora, Manasa K Nayak, Anil K Chauhan

Arterioscler Thromb Vasc Biol· February 2024

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Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm?
Gagan D Flora, Manasa K Nayak, Madankumar Ghatge, Anil K Chauhan

Cardiovasc Res· November 2023

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Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis.
Madankumar Ghatge, Manasa K Nayak, Gagan D Flora, Mariia Kumskova, Aditi Jain

J Thromb Haemost· August 2023

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Characterization of bleeding symptoms in Ehlers-Danlos syndrome.
Mariia Kumskova, Gagan D Flora, Janice Staber, Steven R Lentz, Anil K Chauhan

J Thromb Haemost· July 2023

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Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis.
Gagan D Flora, Manasa K Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B Patel

Blood Adv· June 2023

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Constitutively active ADAMTS13: An emerging thrombolytic agent for acute ischemic stroke.
Manasa K Nayak, Gagan D Flora, Anil K Chauhan

J Thromb Haemost· April 2022

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PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke.
Nirav Dhanesha, Rakesh B Patel, Prakash Doddapattar, Madankumar Ghatge, Gagan D Flora

Blood· February 2022

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The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis.
Manasa K Nayak, Madankumar Ghatge, Gagan D Flora, Nirav Dhanesha, Manish Jain

Blood· March 2021

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Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets.
Khaled A Sahli, Gagan D Flora, Parvathy Sasikumar, Ali H Maghrabi, Lisa-Marie Holbrook

Blood· February 2021

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A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes.
Gagan D Flora, Manasa K Nayak

Curr Pharm Des· June 2020

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Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice.
Nirav Dhanesha, Manasa K Nayak, Prakash Doddapattar, Manish Jain, Gagan D Flora

Blood· March 2020

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Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis.
Gagan D Flora, Khaled A Sahli, Parvathy Sasikumar, Lisa-Marie Holbrook, Alexander R Stainer

Sci Rep· November 2019

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Non-genomic effects of nuclear receptors: insights from the anucleate platelet.
Amanda J Unsworth, Gagan D Flora, Jonathan M Gibbins

Cardiovasc Res· April 2018

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RXR Ligands Negatively Regulate Thrombosis and Hemostasis.
Amanda J Unsworth, Gagan D Flora, Parvathy Sasikumar, Alexander P Bye, Tanya Sage

Arterioscler Thromb Vasc Biol· May 2017

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Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.
Leonardo A Moraes, Amanda J Unsworth, Sakthivel Vaiyapuri, Marfoua S Ali, Parvathy Sasikumar, Gagan D Flora

Arterioscler Thromb Vasc Biol· December 2016

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Pharmacological actions of nobiletin in the modulation of platelet function.
Sakthivel Vaiyapuri, Harvey Roweth, Marfoua S Ali, Amanda J Unsworth, Alexander R Stainer, Gagan D Flora

Br J Pharmacol· August 2015

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Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis.
Sakthivel Vaiyapuri, Gagan D Flora, Jonathan M Gibbins

Biochem Soc Trans· June 2015

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