Publications by authors named "Ganesh Umapathy"

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Comparative analysis of whole-genome sequencing of tumor and cfDNA in a neuroblastoma patient: a case report.
Susanne Fransson, Kleopatra Georgantzi, Anna Djos, Jennie Gaarder, Johanna Svensson, Ganesh Umapathy

Front Oncol· May 2025

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Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance.
Anna Djos, Johanna Svensson, Jennie Gaarder, Ganesh Umapathy, Staffan Nilsson

Genes Chromosomes Cancer· July 2024

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The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the central nervous system.
Sanjay Kumar Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly, Malak Kleit, Ganesh Umapathy

Elife· June 2024

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ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition.
Marcus Borenäs, Ganesh Umapathy, Dan E Lind, Wei-Yun Lai, Jikui Guan

Proc Natl Acad Sci U S A· January 2024

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Telomere Maintenance Mechanisms in a Cohort of High-Risk Neuroblastoma Tumors and Its Relation to Genomic Variants in the and Genes.
Anna Djos, Ketan Thombare, Roshan Vaid, Jennie Gaarder, Ganesh Umapathy

Cancers (Basel)· December 2023

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ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via expression.
Tzu-Po Chuang, Wei-Yun Lai, Jonatan L Gabre, Dan E Lind, Ganesh Umapathy

Proc Natl Acad Sci U S A· February 2023

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Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation.
Diana Treis, Ganesh Umapathy, Susanne Fransson, Jikui Guan, Patricia Mendoza-García

JCO Precis Oncol· January 2022

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Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling.
Farzaneh Aboualizadeh, Zhong Yao, Jikui Guan, Luka Drecun, Shivanthy Pathmanathan, Ganesh Umapathy

J Mol Biol· November 2021

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In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain.
Ezgi Uçkun, Georg Wolfstetter, Vimala Anthonydhason, Sanjay Kumar Sukumar, Ganesh Umapathy

J Mol Biol· November 2021

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ATR inhibition enables complete tumour regression in ALK-driven NB mouse models.
Joanna Szydzik, Dan E Lind, Badrul Arefin, Yeshwant Kurhe, Ganesh Umapathy

Nat Commun· November 2021

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ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
Marcus Borenäs, Ganesh Umapathy, Wei-Yun Lai, Dan E Lind, Barbara Witek

EMBO J· February 2021

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Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGα) in neuroblastoma patient samples with chromosome arm 2p rearrangements.
Niloufar Javanmardi, Susanne Fransson, Anna Djos, Ganesh Umapathy, Malin Östensson

Genes Chromosomes Cancer· January 2020

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The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness.
Liselot M Mus, Irina Lambertz, Shana Claeys, Candy Kumps, Wouter Van Loocke, Ganesh Umapathy

Sci Rep· January 2020

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Alectinib, an Anaplastic Lymphoma Kinase Inhibitor, Abolishes ALK Activity and Growth in ALK-Positive Neuroblastoma Cells.
Muhammad Wasi Alam, Marcus Borenäs, Dan E Lind, Diana Cervantes-Madrid, Ganesh Umapathy

Front Oncol· July 2019

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Targeting anaplastic lymphoma kinase in neuroblastoma.
Ganesh Umapathy, Patricia Mendoza-Garcia, Bengt Hallberg, Ruth H Palmer

APMIS· May 2019

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Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways.
Jimmy Van den Eynden, Ganesh Umapathy, Arghavan Ashouri, Diana Cervantes-Madrid, Joanna Szydzik

Sci Signal· November 2018

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Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib.
Jikui Guan, Susanne Fransson, Joachim Tetteh Siaw, Diana Treis, Jimmy Van den Eynden, Ganesh Umapathy

Cold Spring Harb Mol Case Stud· August 2018

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MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas.
Ganesh Umapathy, Jikui Guan, Dan E Gustafsson, Niloufar Javanmardi, Diana Cervantes-Madrid

Sci Signal· November 2017

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FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.
Jikui Guan, Ganesh Umapathy, Yasuo Yamazaki, Georg Wolfstetter, Patricia Mendoza

Elife· September 2015

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The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.
Ganesh Umapathy, Abeer El Wakil, Barbara Witek, Louis Chesler, Laura Danielson

Sci Signal· October 2014

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Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.
Kamaraj Sattu, Falko Hochgräfe, Jianmin Wu, Ganesh Umapathy, Christina Schönherr

FEBS J· November 2013

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