Publications by authors named "Gangjun Lei"

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CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity.
Bin-Jin Hwang, Erika J Crosby, David T Severson, Timothy N Trotter, Jason McBane, Gangjun Lei

Sci Immunol· December 2025

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Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).
Li-Chung Tsao, John S Wang, Xingru Ma, Sirajbir Sodhi, Joey V Ragusa, Gangjun Lei

Nat Commun· April 2025

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Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer.
Julio C Tinoco, Harmony I Saunders, Lauryn Rose Werner, Xiaopeng Sun, Eilidh I Chowanec, Gangjun Lei

J Immunother Cancer· March 2025

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Vaccines targeting activating mutations elicit anti-tumor immune responses and suppress estrogen signaling in therapy resistant ER+ breast cancer.
Gabrielle P Dailey, Christopher A Rabiola, Gangjun Lei, Junping Wei, Xiao-Yi Yang

Hum Vaccin Immunother· December 2024

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Vaccination Against Androgen Receptor Splice Variants to Immunologically Target Prostate Cancer.
Robert D Marek, Selena Halabi, Mu-En Wang, Jason McBane, Junping Wei, Gangjun Lei

Vaccines (Basel)· November 2024

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Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent "NoGlow" Mice.
Timothy N Trotter, Andrea Wilson, Jason McBane, Carina E Dagotto, Xiao-Yi Yang, Gangjun Lei

Cancer Res Commun· April 2024

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Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3.
Timothy N Trotter, Carina E Dagotto, Delila Serra, Tao Wang, Xiao Yang, Gangjun Lei

JCI Insight· November 2023

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Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.
Li-Chung Tsao, Erika J Crosby, Timothy N Trotter, Junping Wei, Tao Wang, Gangjun Lei

JCI Insight· March 2022

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Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression.
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R Acharya, Timothy Trotter, Pankaj Agarwal, Gangjun Lei

J Immunother Cancer· March 2022

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Progesterone promotes immunomodulation and tumor development in the murine mammary gland.
Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Gangjun Lei

J Immunother Cancer· May 2021

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Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer.
Erika J Crosby, Chaitanya R Acharya, Anthony-Fayez Haddad, Christopher A Rabiola, Gangjun Lei

Clin Cancer Res· September 2020

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IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.
Timothy N Trotter, Casey W Shuptrine, Li-Chung Tsao, Robert D Marek, Chaitanya Acharya, Gangjun Lei

Cancer Res· August 2020

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HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression.
Alan Chen Chen, Renhuan Xu, Tao Wang, Junping Wei, Xiao-Yi Yang, Gangjun Lei

J Immunother Cancer· June 2020

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CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis.
Li-Chung Tsao, Erika J Crosby, Timothy N Trotter, Pankaj Agarwal, Bin-Jin Hwang, Gangjun Lei

JCI Insight· December 2019

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Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.
Takuya Osada, Zachary C Hartman, Junping Wei, Gangjun Lei, Amy C Hobeika

Breast Cancer Res· August 2018

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Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors.
Erika J Crosby, Junping Wei, Xiao Yi Yang, Gangjun Lei, Tao Wang

Oncoimmunology· January 2018

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Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.
Xiu-Rong Ren, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu

Breast Cancer Res· June 2012

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Increasing vaccine potency through exosome antigen targeting.
Zachary C Hartman, Junping Wei, Oliver K Glass, Hongtao Guo, Gangjun Lei

Vaccine· November 2011

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HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis.
Zachary C Hartman, Xiao-Yi Yang, Oliver Glass, Gangjun Lei, Takuya Osada

Cancer Res· July 2011

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Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity.
Zachary C Hartman, Takuya Osada, Oliver Glass, Xiao Y Yang, Gang-Jun Lei

Cancer Res· September 2010

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Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.
Michael A Morse, Junping Wei, Zachary Hartman, Wenle Xia, Xiu-Rong Ren, Gangjun Lei

Int J Cancer· June 2010

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An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity.
Zachary C Hartman, Junping Wei, Takuya Osada, Oliver Glass, Gangjun Lei

Clin Cancer Res· March 2010

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Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine.
Takuya Osada, Christopher Y Woo, Matthew McKinney, Xiao Yi Yang, Gangjun Lei

Clin Cancer Res· April 2009

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