Publications by authors named "Gary Acton"

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Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Simon Eschweiler, Ciro Ramírez-Suástegui, Yingcong Li, Emma King, Lindsey Chudley, Gary Acton

Nature· May 2022

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Phase Ib dose-escalation study of the selective, non-covalent, reversible Bruton's tyrosine kinase inhibitor vecabrutinib in B-cell malignancies.
John N Allan, Javier Pinilla-Ibarz, Douglas E Gladstone, Krish Patel, Jeff P Sharman, Gary Acton

Haematologica· April 2022

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Clinical proof of concept for a safe and effective NF-κB-targeting strategy in multiple myeloma.
Laura Tornatore, Daria Capece, Daniel D'Andrea, Federica Begalli, Daniela Verzella, Gary Acton

Br J Haematol· May 2019

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Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3.
Laura Tornatore, Daria Capece, Daniel D'Andrea, Federica Begalli, Daniela Verzella, Gary Acton

Toxicol Rep· April 2019

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Phase 3 results for vosaroxin/cytarabine in the subset of patients ≥60 years old with refractory/early relapsed acute myeloid leukemia.
Farhad Ravandi, Ellen K Ritchie, Hamid Sayar, Jeffrey E Lancet, Michael D Craig, Gary Acton

Haematologica· November 2018

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Trends in the characteristics, dose-limiting toxicities and efficacy of phase I oncology trials: The Cancer Research UK experience.
Han Hsi Wong, Claire Barton, Gary Acton, Robert McLeod, Sarah Halford

Eur J Cancer· October 2016

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Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.
Yvette Drew, Jonathan Ledermann, Geoff Hall, Daniel Rea, Ros Glasspool, Gary Acton

Br J Cancer· June 2016

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Antarctic ice sheet sensitivity to atmospheric CO2 variations in the early to mid-Miocene.
Richard Levy, David Harwood, Fabio Florindo, Francesca Sangiorgi, Robert Tripati, Gary Acton

Proc Natl Acad Sci U S A· March 2016

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Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.
Yvette Drew, Jonathan Ledermann, Geoff Hall, Daniel Rea, Ros Glasspool, Gary Acton

Br J Cancer· March 2016

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Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study.
Farhad Ravandi, Ellen K Ritchie, Hamid Sayar, Jeffrey E Lancet, Michael D Craig, Gary Acton

Lancet Oncol· September 2015

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Statistical Considerations in Clinical Trial Design of Immunotherapeutic Cancer Agents.
George Dranitsaris, Roger B Cohen, Gary Acton, Llew Keltner, Melissa Price

J Immunother· September 2015

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A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study.
Lucas Moreno, Lynley V Marshall, Andrew D J Pearson, Bruce Morland, Martin Elliott, Gary Acton

Clin Cancer Res· January 2015

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Paleoceanography. Onset of Mediterranean outflow into the North Atlantic.
F Javier Hernández-Molina, Dorrik A V Stow, Carlos A Alvarez-Zarikian, Gary Acton, André Bahr

Science· June 2014

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A Cenozoic record of the equatorial Pacific carbonate compensation depth.
Heiko Pälike, Mitchell W Lyle, Hiroshi Nishi, Isabella Raffi, Andy Ridgwell, Gary Acton

Nature· August 2012

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Randomized phase II trial of letrozole plus anti-MUC1 antibody AS1402 in hormone receptor-positive locally advanced or metastatic breast cancer.
Nuhad K Ibrahim, Kemal O Yariz, Ihor Bondarenko, Alexei Manikhas, Vladimir Semiglazov, Gary Acton

Clin Cancer Res· November 2011

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A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma.
Sarah M Rudman, Michael B Jameson, Mark J McKeage, Philip Savage, Duncan I Jodrell, Gary Acton

Clin Cancer Res· April 2011

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Transient retinal effects of 5,6-dimethylxanthenone-4-acetic acid (DMXAA, ASA404), an antitumor vascular-disrupting agent in phase I clinical trials.
Michael B Jameson, Dianne M Sharp, Jennifer I Sissingh, Christopher R Hogg, Paul I Thompson, Gary Acton

Invest Ophthalmol Vis Sci· June 2009

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Drilling to gabbro in intact ocean crust.
Douglas S Wilson, Damon A H Teagle, Jeffrey C Alt, Neil R Banerjee, Susumu Umino, Gary D Acton

Science· May 2006

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