Publications by authors named "Gary D Lopaschuk"

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The Impact of Obesity on Cardiac Energy Metabolism and Efficiency in Heart Failure With Preserved Ejection Fraction.
Ezra B Ketema, Gary D Lopaschuk

Can J Cardiol· September 2025

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The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC.
Gabriele Fragasso, Davide Stolfo, Markus S Anker, Antoni Bayes-Genis, Ovidiu Chioncel, Gary D Lopaschuk

Eur J Heart Fail· September 2025

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Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.
Qutuba G Karwi, Liyan Zhang, Keshav Gopal, Cory S Wagg, Kim L Ho, Gary D Lopaschuk

Circ Heart Fail· September 2025

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Alterations of myocardial ketone metabolism in heart failure with preserved ejection fraction (HFpEF).
Qiuyu Sun, Cory S Wagg, Nathan Wong, Kaleigh Wei, Ezra B Ketema, Gary D Lopaschuk

ESC Heart Fail· August 2025

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Sweeteners: erythritol, xylitol and cardiovascular risk-friend or foe?
Bettina K Wölnerhanssen, Anne Christin Meyer-Gerspach, Arduino Arduini, Angelo D'Alessandro, Edoardo Gronda, Gary D Lopaschuk

Cardiovasc Res· August 2025

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Casein Kinase 2α Ablation Confers Protection Against Metabolic Dysfunction-Associated Steatotic Liver Disease: Role of FUN14 Domain Containing 1-Dependent Regulation of Mitophagy and Ferroptosis.
Ke He, Meixiao Zhan, Xuanming Luo, Ruibing Li, Ling Lin, Gary D Lopaschuk

MedComm (2020)· July 2025

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Cardiac energy substrate utilization in heart failure with preserved ejection fraction: reconciling conflicting evidence on fatty acid and glucose metabolism.
Lina A Shehadeh, Emely Robleto, Gary D Lopaschuk

Am J Physiol Heart Circ Physiol· June 2025

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Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications.
Archee Panwar, Sufyan O Malik, Muhtasim Adib, Gary D Lopaschuk

Am J Physiol Heart Circ Physiol· May 2025

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Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3.
Ahmed M Darwesh, Liye Fang, Tariq R Altamimi, K Lockhart Jamieson, Wesam Bassiouni, Gary D Lopaschuk

Cardiovasc Res· April 2025

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Impact of Cholesterol on Cardiac Mitochondrial Function.
Gary D Lopaschuk

Circ Res· April 2025

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Invited Commentary: What Is the Link Between Ferroptosis and Cardiac Hypertrophy?
Qiuyu Sun, Gary D Lopaschuk

Can J Cardiol· February 2025

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Glycolysis in heart failure with preserved ejection fraction.
Gary D Lopaschuk, Qiuyu Sun, Ezra B Ketema

Eur J Heart Fail· December 2024

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Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond.
Qiuyu Sun, Qutuba G Karwi, Nathan Wong, Gary D Lopaschuk

Cardiovasc Res· December 2024

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Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics.
Karm A Alhasan, Melissa A King, Badal S B Pattar, Ian A Lewis, Gary D Lopaschuk

Cardiovasc Res· December 2024

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The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischaemic heart failure.
Kim L Ho, Qutuba G Karwi, Faqi Wang, Cory Wagg, Liyan Zhang, Gary D Lopaschuk

Cardiovasc Res· September 2024

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The role of acetylation in obesity-induced cardiac metabolic alterations.
Ezra B Ketema, Gary D Lopaschuk

J Pharm Pharm Sci· August 2024

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The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance.
Abdualrahman Mohammed Abdualkader, Qutuba G Karwi, Gary D Lopaschuk, Rami Al Batran

J Pharm Pharm Sci· July 2024

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Impaired Cardiac AMPK (5'-Adenosine Monophosphate-Activated Protein Kinase) and Ca-Handling, and Action Potential Duration Heterogeneity in Ibrutinib-Induced Ventricular Arrhythmia Vulnerability.
Yanan Zhao, Beibei Du, Praloy Chakraborty, Nathan Denham, Stéphane Massé, Gary D Lopaschuk

J Am Heart Assoc· June 2024

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A self-reinforcing cycle hypothesis in heart failure pathogenesis.
Carlos Fernandez-Patron, Gary D Lopaschuk, Eugenio Hardy

Nat Cardiovasc Res· June 2024

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Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation.
Simran Pherwani, David Connolly, Qiuyu Sun, Qutuba G Karwi, Michael Carr, Gary D Lopaschuk

Metabolism· May 2024

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Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy.
Amanda A Greenwell, Seyed Amirhossein Tabatabaei Dakhili, Cory S Wagg, Christina T Saed, Jordan S F Chan, Gary D Lopaschuk

J Am Heart Assoc· April 2024

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Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction.
Qiuyu Sun, Berna Güven, Cory S Wagg, Amanda Almeida de Oliveira, Heidi Silver, Gary D Lopaschuk

Cardiovasc Res· March 2024

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Stimulating cardiac glucose oxidation lessens the severity of heart failure in aged female mice.
Qiuyu Sun, Cory S Wagg, Berna Güven, Kaleigh Wei, Amanda A de Oliveira, Gary D Lopaschuk

Basic Res Cardiol· February 2024

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Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF).
Sungji Cho, Keith Dadson, Hye Kyoung Sung, Oyeronke Ayansola, Ali Mirzaesmaeili, Gary D Lopaschuk

Biomed Pharmacother· February 2024

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Protein lysine acetylation does not contribute to the high rates of fatty acid oxidation seen in the post-ischemic heart.
Ezra B Ketema, Muhammad Ahsan, Liyan Zhang, Qutuba G Karwi, Gary D Lopaschuk

Sci Rep· January 2024

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