Publications by authors named "Gary Daughdrill"

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Discovery of peptidomimetic inhibitors of CREB/CBP by targeting hydrophobic grooves on the surface of the CBP KIX domain.
Bo Huang, Emily Gregory-Lott, Bingbing X Li, Timothy H Tran, Sihao Li, Gary Daughdrill

Acta Pharm Sin B· December 2025

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Recognition of the CREB-Binding Protein/Mixed Lineage Leukemia Interface by Sulfonyl-γ-AApeptides: Beyond Mimicry of Mixed Lineage Leukemia.
Bo Huang, Minghui Wang, Emily Gregory-Lott, Bingbing X Li, Yu Yu Win, Gary W Daughdrill

J Med Chem· June 2025

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Structural Adaptation of Secondary p53 Binding Sites on MDM2 and MDMX.
Pirada Serena Higbee, Guy W Dayhoff, Asokan Anbanandam, Sameer Varma, Gary Daughdrill

J Mol Biol· July 2024

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Protein disorder and autoinhibition: The role of multivalency and effective concentration.
Malissa Fenton, Emily Gregory, Gary Daughdrill

Curr Opin Struct Biol· December 2023

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The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX.
Malissa Fenton, Wade Borcherds, Lihong Chen, Asokan Anbanandam, Robin Levy, Gary Daughdrill

J Mol Biol· November 2022

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Sequence Properties of An Intramolecular Interaction That Inhibits p53 DNA Binding.
Emily Gregory, Gary W Daughdrill

Biomolecules· October 2022

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Conformational buffering underlies functional selection in intrinsically disordered protein regions.
Nicolás S González-Foutel, Juliana Glavina, Wade M Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Gary W Daughdrill

Nat Struct Mol Biol· August 2022

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Disorder for Dummies: Functional Mutagenesis of Transient Helical Segments in Disordered Proteins.
Gary W Daughdrill

Methods Mol Biol· March 2021

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Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein-Protein Interactions.
Yan Shi, Peng Sang, Junhao Lu, Pirada Higbee, Lihong Chen, Gary Daughdrill

J Med Chem· November 2020

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Correction to α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions.
Peng Sang, Yan Shi, Junhao Lu, Lihong Chen, Leixiang Yang, Gary Daughdrill

J Med Chem· September 2020

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Rational Design and Synthesis of Right-Handed d-Sulfono-γ-AApeptide Helical Foldamers as Potent Inhibitors of Protein-Protein Interactions.
Peng Sang, Yan Shi, Pirada Higbee, Minghui Wang, Sami Abdulkadir, Gary Daughdrill

J Org Chem· August 2020

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Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity.
Qingliang Li, Rezaul M Karim, Mo Cheng, Mousumi Das, Lihong Chen, Gary W Daughdrill

Oncogene· July 2020

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α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions.
Peng Sang, Yan Shi, Junhao Lu, Lihong Chen, Leixiang Yang, Gary Daughdrill

J Med Chem· February 2020

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Using NMR Chemical Shifts to Determine Residue-Specific Secondary Structure Populations for Intrinsically Disordered Proteins.
Wade M Borcherds, Gary W Daughdrill

Methods Enzymol· July 2019

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Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding.
Fan He, Wade Borcherds, Tanjing Song, Xi Wei, Mousumi Das, Gary W Daughdrill

Proc Natl Acad Sci U S A· April 2019

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p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX.
Robin Levy, Emily Gregory, Wade Borcherds, Gary Daughdrill

Biomolecules· March 2019

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Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A.
Oluwakemi T Sowemimo, Patrick Knox-Brown, Wade Borcherds, Tobias Rindfleisch, Anja Thalhammer, Gary W Daughdrill

Biomolecules· March 2019

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Uncoupling the Folding and Binding of an Intrinsically Disordered Protein.
Anusha Poosapati, Emily Gregory, Wade M Borcherds, Lucia B Chemes, Gary W Daughdrill

J Mol Biol· August 2018

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Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex.
Michael D Crabtree, Wade Borcherds, Anusha Poosapati, Sarah L Shammas, Gary W Daughdrill

Biochemistry· May 2017

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Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX.
Wade Borcherds, Andreas Becker, Lihong Chen, Jiandong Chen, Lucía B Chemes, Gary W Daughdrill

Biophys J· May 2017

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Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.
Xi Wei, Shaofang Wu, Tanjing Song, Lihong Chen, Ming Gao, Gary W Daughdrill

Proc Natl Acad Sci U S A· May 2016

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Autoinhibition of MDMX by intramolecular p53 mimicry.
Lihong Chen, Wade Borcherds, Shaofang Wu, Andreas Becker, Ernst Schonbrunn, Gary W Daughdrill

Proc Natl Acad Sci U S A· April 2015

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Using chemical shifts to generate structural ensembles for intrinsically disordered proteins with converged distributions of secondary structure.
F Marty Ytreberg, Wade Borcherds, Hongwei Wu, Gary W Daughdrill

Intrinsically Disord Proteins· February 2015

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Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Wade Borcherds, François-Xavier Theillet, Andrea Katzer, Ana Finzel, Katie M Mishall, Gary W Daughdrill

Nat Chem Biol· December 2014

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Classification of intrinsically disordered regions and proteins.
Robin van der Lee, Marija Buljan, Benjamin Lang, Robert J Weatheritt, Gary W Daughdrill

Chem Rev· July 2014

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