Publications by authors named "Gary McCort"

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SAR340835, a Novel Selective Na/Ca Exchanger Inhibitor, Improves Cardiac Function and Restores Sympathovagal Balance in Heart Failure.
Michel Pelat, Fabrice Barbe, Cyril Daveu, Laetitia Ly-Nguyen, Thomas Lartigue, Gary McCort

J Pharmacol Exp Ther· May 2021

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SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Maysoun Shomali, Jane Cheng, Fangxian Sun, Malvika Koundinya, Zhuyan Guo, Gary McCort

Mol Cancer Ther· February 2021

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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
Youssef El-Ahmad, Michel Tabart, Frank Halley, Victor Certal, Fabienne Thompson, Gary McCort

J Med Chem· January 2020

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Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.
Benoit Pasquier, Youssef El-Ahmad, Bruno Filoche-Rommé, Christine Dureuil, Florence Fassy, Gary McCort

J Med Chem· January 2015

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The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1.
Kwame Amaning, Maryse Lowinski, Francois Vallee, Valerie Steier, Christophe Marcireau, Gary McCort

Bioorg Med Chem Lett· June 2013

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Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.
Hans Matter, Bodo Scheiper, Henning Steinhagen, Zsolt Böcskei, Valérie Fleury, Gary McCort

Bioorg Med Chem Lett· September 2011

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Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
Bodo Scheiper, Hans Matter, Henning Steinhagen, Zsolt Böcskei, Valérie Fleury, Gary McCort

Bioorg Med Chem Lett· September 2011

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Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.
Bodo Scheiper, Hans Matter, Henning Steinhagen, Ulrich Stilz, Zsolt Böcskei, Gary McCort

Bioorg Med Chem Lett· November 2010

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Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists.
Frédérique Guilbert, Pierre Lainée, Brigitte Dubreuil, Gary McCort, Stephen E O'Connor

Eur J Pharmacol· August 2004

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