Publications by authors named "Gavin MacBeath"

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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.
Qinqin Jiang, David A Braun, Karl R Clauser, Vijyendra Ramesh, Nitin H Shirole, Gavin MacBeath

Cell· April 2025

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A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics.
Miriam Meyer, Andrea Mahr, Joanna Brewer, Volker Daniel, Justine Dell'Aringa, Gavin MacBeath

Nat Rev Drug Discov· January 2024

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Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.
Adrienne M Luoma, Shengbao Suo, Yifan Wang, Lauren Gunasti, Caroline B M Porter, Gavin MacBeath

Cell· August 2022

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Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors.
Crystal S Denlinger, Vicki L Keedy, Victor Moyo, Gavin MacBeath, Geoffrey I Shapiro

Invest New Drugs· December 2021

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Phenotype, specificity and avidity of antitumour CD8 T cells in melanoma.
Giacomo Oliveira, Kari Stromhaug, Susan Klaeger, Tomasz Kula, Dennie T Frederick, Gavin MacBeath

Nature· August 2021

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Unbiased Screens Show CD8 T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.
Andrew P Ferretti, Tomasz Kula, Yifan Wang, Dalena M V Nguyen, Adam Weinheimer, Gavin MacBeath

Immunity· November 2020

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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Jessica B Casaletto, Melissa L Geddie, Adnan O Abu-Yousif, Kristina Masson, Aaron Fulgham, Gavin MacBeath

Proc Natl Acad Sci U S A· April 2019

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Estimation of immune cell content in tumour tissue using single-cell RNA-seq data.
Max Schelker, Sonia Feau, Jinyan Du, Nav Ranu, Edda Klipp, Gavin MacBeath

Nat Commun· December 2017

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Predicting ligand-dependent tumors from multi-dimensional signaling features.
Helge Hass, Kristina Masson, Sibylle Wohlgemuth, Violette Paragas, John E Allen, Gavin MacBeath

NPJ Syst Biol Appl· September 2017

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A phase 1 study combining the HER3 antibody seribantumab (MM-121) and cetuximab with and without irinotecan.
James M Cleary, Autumn J McRee, Geoffrey I Shapiro, Sara M Tolaney, Bert H O'Neil, Gavin MacBeath

Invest New Drugs· February 2017

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Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).
Birgit Schoeberl, Art Kudla, Kristina Masson, Ashish Kalra, Michael Curley, Gavin MacBeath

NPJ Syst Biol Appl· January 2017

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Randomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer.
Joyce F Liu, Isabelle Ray-Coquard, Frederic Selle, Andrés M Poveda, David Cibula, Gavin MacBeath

J Clin Oncol· December 2016

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Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model.
Michael D Curley, Gauri J Sabnis, Lucia Wille, Bambang S Adiwijaya, Gabriela Garcia, Gavin MacBeath

Mol Cancer Ther· November 2015

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Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma.
Guoqing Qian, Ning Jiang, Dongsheng Wang, Scott Newman, Sungjin Kim, Gavin MacBeath

Cancer· October 2015

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Heregulin-ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells.
Defne Yarar, Johanna Lahdenranta, William Kubasek, Ulrik B Nielsen, Gavin MacBeath

Mol Cancer Ther· September 2015

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A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.
Mohammed AlQuraishi, Grigoriy Koytiger, Anne Jenney, Gavin MacBeath, Peter K Sorger

Nat Genet· December 2014

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A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
Taranjit S Gujral, Marina Chan, Leonid Peshkin, Peter K Sorger, Marc W Kirschner, Gavin MacBeath

Cell· November 2014

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Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.
Chae-ryun Yi, John E Allen, Brian Russo, Soo Young Lee, Jason E Heindl, Gavin MacBeath

J Biol Chem· October 2014

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Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma.
Ning Jiang, Dongsheng Wang, Zhongliang Hu, Hyung Ju C Shin, Guoqing Qian, Gavin MacBeath

Mol Cancer Ther· July 2014

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Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients.
Matthew D Onsum, Elena Geretti, Violette Paragas, Arthur J Kudla, Sharon P Moulis, Gavin MacBeath

Am J Pathol· November 2013

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Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.
Joel P Wagner, Alejandro Wolf-Yadlin, Mark Sevecka, Jennifer K Grenier, David E Root, Gavin MacBeath

Sci Signal· July 2013

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Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions.
Taranjit S Gujral, Ethan S Karp, Marina Chan, Bryan H Chang, Gavin MacBeath

Chem Biol· June 2013

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Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected.
Grigoriy Koytiger, Alexis Kaushansky, Andrew Gordus, John Rush, Peter K Sorger, Gavin MacBeath

Mol Cell Proteomics· May 2013

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Suppression of host p53 is critical for Plasmodium liver-stage infection.
Alexis Kaushansky, Albert S Ye, Laura S Austin, Sebastian A Mikolajczak, Ashley M Vaughan, Gavin MacBeath

Cell Rep· March 2013

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Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.
Michael J Lee, Albert S Ye, Alexandra K Gardino, Anne Margriet Heijink, Peter K Sorger, Gavin MacBeath

Cell· May 2012

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