Publications by authors named "Geert Raes"

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Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD-1 Immunotherapy.
Sana M Arnouk, Daliya Kancheva, Helena Van Damme, Guillaume E Courtoy, Romina Mora Barthelmess, Geert Raes

Cancer Res· December 2025

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VSIG4 Is Dispensable for Tumor Growth and Metastasis in Murine Colorectal and Breast Cancer Models.
Els Lebegge, Neema Ahishakiye Jumapili, Jolien Van Craenenbroeck, Daliya Kancheva, Máté Kiss, Geert Raes

Cancers (Basel)· October 2025

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VSIG4-Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity.
Els Lebegge, Daliya Kancheva, Jolien Van Craenenbroeck, Sam Ernst, Pauline M R Bardet, Geert Raes

Eur J Immunol· May 2025

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Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.
Timo W M De Groof, Yoline Lauwers, Tessa De Pauw, Mohit Saxena, Cécile Vincke, Geert Raes

Eur J Nucl Med Mol Imaging· December 2024

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Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer.
Yoline Lauwers, Timo W M De Groof, Cécile Vincke, Jolien Van Craenenbroeck, Neema Ahishakiye Jumapili, Geert Raes

Proc Natl Acad Sci U S A· December 2024

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Editorial: Immunometabolism in autoimmune and autoinflammatory disorders.
Fang Zheng, Geert Raes, Shemin Lu, Qian Chen

Front Immunol· December 2023

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Current status and future expectations of nanobodies in oncology trials.
Tessa De Pauw, Lynn De Mey, Jens M Debacker, Geert Raes, Jo A Van Ginderachter

Expert Opin Investig Drugs· November 2023

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In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4 T cells.
Robin Maximilian Awad, Yannick De Vlaeminck, Fien Meeus, Thomas Ertveldt, Katty Zeven, Geert Raes

Sci Rep· November 2023

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Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT.
Katty Zeven, Timo W M De Groof, Hannelore Ceuppens, Robin Maximilian Awad, Thomas Ertveldt, Geert Raes

Front Immunol· October 2023

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A few good reasons to use nanobodies for cancer treatment.
Neema Ahishakiye Jumapili, Maida Zivalj, Romina Mora Barthelmess, Geert Raes, Timo W M De Groof

Eur J Immunol· September 2023

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Phase I Study of [Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I).
Odrade Gondry, Catarina Xavier, Laurens Raes, Johannes Heemskerk, Nick Devoogdt, Geert Raes

J Nucl Med· September 2023

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Applications of nanobodies in brain diseases.
Fang Zheng, Yucheng Pang, Luyao Li, Yuxing Pang, Jiaxin Zhang, Geert Raes

Front Immunol· November 2022

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Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages.
Zohreh Varasteh, Miriam Braeuer, Sarajo Mohanta, Anna-Lena Steinsiek, Andreas Habenicht, Geert Raes

Front Cardiovasc Med· April 2022

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Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
Karen De Vlaminck, Ema Romão, Janik Puttemans, Ana Rita Pombo Antunes, Daliya Kancheva, Geert Raes

Front Immunol· February 2022

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Dendritic Cell-Based Immunotherapy in Multiple Myeloma: Challenges, Opportunities, and Future Directions.
Emma Verheye, Jesús Bravo Melgar, Sofie Deschoemaeker, Geert Raes, Anke Maes

Int J Mol Sci· January 2022

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Single-Domain Antibody Nuclear Imaging Allows Noninvasive Quantification of LAG-3 Expression by Tumor-Infiltrating Leukocytes and Predicts Response of Immune Checkpoint Blockade.
Quentin Lecocq, Robin Maximilian Awad, Yannick De Vlaeminck, Wout de Mey, Thomas Ertveldt, Geert Raes

J Nucl Med· November 2021

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Development and Characterization of Nanobodies Targeting the Kupffer Cell.
Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Geert Raes

Front Immunol· September 2021

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Lyophilization of NOTA-sdAbs: First step towards a cold diagnostic kit for Ga-labeling.
Henri Baudhuin, Pieter-Jan Van Bockstal, Thomas De Beer, Ilse Vaneycken, Jessica Bridoux, Geert Raes

Eur J Pharm Biopharm· September 2021

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Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade.
Robin Maximilian Awad, Quentin Lecocq, Katty Zeven, Thomas Ertveldt, Lien De Beck, Geert Raes

Mol Ther Methods Clin Dev· September 2021

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Phase I Trial of I-GMIB-Anti-HER2-VHH1, a New Promising Candidate for HER2-Targeted Radionuclide Therapy in Breast Cancer Patients.
Matthias D'Huyvetter, Jens De Vos, Vicky Caveliers, Ilse Vaneycken, Johannes Heemskerk, Geert Raes

J Nucl Med· August 2021

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Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers.
Henri Baudhuin, Julie Cousaert, Philippe Vanwolleghem, Geert Raes, Vicky Caveliers

Pharmaceuticals (Basel)· May 2021

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Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality.
Henri Baudhuin, Janik Puttemans, Heleen Hanssens, Philippe Vanwolleghem, Sophie Hernot, Geert Raes

Pharmaceuticals (Basel)· April 2021

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IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D.
Máté Kiss, Lieselotte Vande Walle, Pedro H V Saavedra, Els Lebegge, Helena Van Damme, Geert Raes

Cancer Immunol Res· March 2021

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Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation.
Jessica Bridoux, Katrijn Broos, Quentin Lecocq, Pieterjan Debie, Charlotte Martin, Geert Raes

Biomolecules· September 2020

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Systemic Reprogramming of Monocytes in Cancer.
Máté Kiss, Aarushi Audhut Caro, Geert Raes, Damya Laoui

Front Oncol· September 2020

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