Publications by authors named "Geming Lu"

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Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system.
Carolina Rosselot, Yansui Li, Peng Wang, Alexandra Alvarsson, Kara Beliard, Geming Lu, Randy Kang, Rosemary Li, Hongtao Liu, Virginia Gillespie

Sci Transl Med· July 2024

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Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles.
Randy B Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F Stewart, Donald K Scott, Adolfo Garcia-Ocana, Geming Lu

Genome Med· May 2023

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A simple approach of nuclei isolation for single nucleus multiome sequencing.
Yin Wang, Di Ren, Randy Kang, Kai Zhang, Yunqian Peng, Geming Lu

J Mol Cell Cardiol· November 2025

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Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene.
Randy B Kang, Miguel Varela, Eunjin Oh, Jungeun Lee, Tuo Zhang, Geming Lu

Nat Commun· October 2025

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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK.
Joanna Filipowska, Zelda Cisneros, Sneha S Varghese, Nancy Leon-Rivera, Peng Wang, Geming Lu, Nagesha Guthalu Kondegowda

Mol Metab· February 2025

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Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors.
Esra Karakose, Xuedi Wang, Peng Wang, Saul Carcamo, Deniz Demircioglu, Luca Lambertini, Geming Lu

Cell Rep Med· December 2024

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A Phase 1 single ascending dose study of pure oral harmine in healthy volunteers.
Jessica L Ables, Leah Israel, Olivia Wood, Usha Govindarajulu, Rachel T Fremont, Geming Lu

J Psychopharmacol· October 2024

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Cholesterol 25-Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4.
Lu Zhang, Zhengying Fang, Qingqing Zhu, Shumin Yang, Jia Fu, Geming Lu

Adv Sci (Weinh)· August 2024

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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK.
Joanna Filipowska, Zelda Cisneros, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Nagesha Guthalu Kondegowda

bioRxiv· May 2024

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Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms.
Randy B Kang, Jungeun Lee, Miguel Varela, Yansui Li, Carolina Rosselot, Geming Lu

bioRxiv· November 2023

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Puerarin attenuates diabetic kidney injury through interaction with Guanidine nucleotide-binding protein Gi subunit alpha-1 (Gnai1) subunit.
Qingqing Zhu, Shumin Yang, Chengguo Wei, Geming Lu, Kyung Lee

J Cell Mol Med· July 2022

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The many lives of Myc in the pancreatic β-cell.
Carolina Rosselot, Sharon Baumel-Alterzon, Yansui Li, Gabriel Brill, Luca Lambertini, Geming Lu

J Biol Chem· July 2021

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Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes.
Geming Lu, Francisco Rausell-Palamos, Jiamin Zhang, Zihan Zheng, Tuo Zhang

Diabetes· August 2020

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Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet.
Carolina Rosselot, Anil Kumar, Jayalakshmi Lakshmipathi, Pili Zhang, Geming Lu, Luca Lambertini

Diabetes· October 2019

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T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.
Ruihua Zhang, Chen-Feng Qi, Yuan Hu, Yanhong Shan, Yuan-Pang Hsieh, Geming Lu

J Autoimmun· January 2019

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NLRP3 Inflammasome Activation Regulates Aged RBC Clearance.
Li Qin, Zhao Fengyong, Zhang Jiamin, Yang Qixiu, Lu Geming

Inflammation· August 2018

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Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Ka Lung Cheung, Fan Zhang, Anbalagan Jaganathan, Rajal Sharma, Qiang Zhang, Geming Lu

Mol Cell· March 2017

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BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Kalung Cheung, Geming Lu, Rajal Sharma, Adam Vincek, Ruihua Zhang

Proc Natl Acad Sci U S A· March 2017

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Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5.
Liang Peng, Hui Zhang, Yuanyuan Hao, Feihong Xu, Jianjun Yang, Geming Lu

EBioMedicine· December 2016

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Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells.
Chuanping Si, Ruihua Zhang, Tianshu Wu, Geming Lu, Yuan Hu

Oncotarget· November 2016

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A network medicine approach to build a comprehensive atlas for the prognosis of human cancer.
Fan Zhang, Chunyan Ren, Kwun Kit Lau, Zihan Zheng, Geming Lu

Brief Bioinform· November 2016

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5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation.
Juan Wang, Liang Peng, Ruihua Zhang, Zihan Zheng, Chun Chen, Ka Lung Cheung, Geming Lu

Oncotarget· April 2016

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IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation.
Amy V Paschall, Ruihua Zhang, Chen-Feng Qi, Kankana Bardhan, Liang Peng, Geming Lu

J Immunol· March 2015

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Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization.
Geming Lu, Ruihua Zhang, Shuo Geng, Liang Peng, Padmini Jayaraman

Nat Commun· March 2015

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iNOS expression in CD4+ T cells limits Treg induction by repressing TGFβ1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity.
Padmini Jayaraman, Matthew G Alfarano, Peter F Svider, Falguni Parikh, Geming Lu

Clin Cancer Res· December 2014

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