Sci Transl Med July 2024 PMID 38985854

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system.

Carolina Rosselot, Yansui Li, Peng Wang, Alexandra Alvarsson, Kara Beliard, Geming Lu, Randy Kang, Rosemary Li, Hongtao Liu, Virginia Gillespie, Nikolaos Tzavaras, Kunal Kumar, Robert J DeVita, Andrew F Stewart, Sarah A Stanley

Mentions

129
Peak: 60 in Jul 2024
across 4 sources since Jul 2024

Extended reach

384,553
potential audience

Total likes

2,674

Video views

57,026

Mentions per month

Jul 2024 – Feb 2025

Where it's discussed

  • X / Twitter68 posts
  • News53 articles
  • Blogs5 articles
  • YouTube3 videos

AI synopsis

What people are saying

The overall tone reflects enthusiasm about the therapy’s ability to expand human beta cell mass, with discussions emphasizing its potential to reverse or significantly improve diabetes, exemplified by phrases like 'significant impact' and 'breakthrough.' Posts referencing collaboration and scientific advances, such as 'City of Hope and Mount Sinai scientists,' contribute to a perception of high impact, while some comments express curiosity about its mechanisms, showing moderate interest and engagement.

AgreementModerate agreement

Most discussions affirm the significance of the therapy and its potential for diabetes treatment, indicating general consensus.

InterestModerate interest

Participants show moderate interest, interested enough to share and comment on the novelty and significance of the therapy.

EngagementModerate engagement

Comments include references to scientific methods, collaborations, and terminology such as 'combination therapy' and 'beta cell mass,' demonstrating some depth.

ImpactHigh impact

Many posts highlight the potential to transform diabetes treatment, emphasizing breakthroughs and future implications, suggesting high perceived impact.

Top posts

Most liked on X and Bluesky
Blue Jack
@BlueJakk · X

داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷۰۰ درصد افزایش بده! https://t.co/s4JhnDIaqF

Jul 15, 2024 · 605 likes · 10 shares · 46,811 followers View post →
Adolfo Garcia Ocaña. Ph.D.
@AGOcanaLab_COH · X

Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system. https://t.co/TFLqLzEKYz

Jul 10, 2024 · 40 likes · 13 shares · 157 followers View post →
Heiko Lickert
@LickertHeiko · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/U1bf2huLJQ

Jul 10, 2024 · 24 likes · 3 shares · 3,048 followers View post →
Adolfo Garcia Ocaña. Ph.D.
@AGOcanaLab_COH · X

City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-producing cells in vivo https://t.co/CiufdrsM07 The related work is published in Science Translational Medicine. https://t.co/TFLqLzEKYz

Jul 10, 2024 · 23 likes · 5 shares · 157 followers View post →
Daniel J Drucker
@DanielJDrucker · X

Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function, and survival #islets @ScienceTM https://t.co/bKT5PfmCT7

Jul 10, 2024 · 18 likes · 7 shares · 34,083 followers View post →
Randy Kang
@randystyle · X

STM article from our lab is finally out!! https://t.co/qIwqvHif9u

Jul 10, 2024 · 10 likes · 1 share · 73 followers View post →

All mentions

WILSON GERALDO
@BrigidoGeraldo · X

https://t.co/VXeXQVKdRI

Feb 26, 2025 · 3,108 followers View post →
David G. Armstrong follow @dgarmstrong.bsky.social
@DGArmstrong · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/4hBCnmfrHx https://t.co/sDKhwzHHpk

Dec 7, 2024 · 11,916 followers View post →
Guías del Psiconauta
@guiaspsiconauta · X

Dec 6, 2024 · 809 followers View post →
Peeref
@Peeref1 · X

Nov 20, 2024 · 161 followers View post →
David G. Armstrong follow @dgarmstrong.bsky.social
@DGArmstrong · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/4hBCnmfrHx https://t.co/plZXViPPnL

Nov 3, 2024 · 11,916 followers View post →
⭐Pαlєσlíвєrtαríσ-
@FREE_PTY_2285 · X

@armandoalducin https://t.co/aCI06pzwHQ

Oct 12, 2024 · 540 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @DGArmstrong: Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science T…

Sep 26, 2024 · 1 share · 32,519 followers View post →
David G. Armstrong follow @dgarmstrong.bsky.social
@DGArmstrong · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/4hBCnmfrHx https://t.co/U1LcmiKBUC

Sep 26, 2024 · 2 likes · 1 share · 11,916 followers View post →
David G. Armstrong follow @dgarmstrong.bsky.social
@DGArmstrong · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/4hBCnmfrHx https://t.co/T94F5l5dd3

Aug 20, 2024 · 11,916 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

The original paper -> https://t.co/KqtCk6NnI6

Aug 5, 2024 · 1 like · 35,338 followers View post →
Prof Sam El-Osta
@SamElOsta1 · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/1YVEW8lC4f

Aug 3, 2024 · 805 followers View post →
Harmalogy
@harmalogy · X

RT @DanielJDrucker: Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function…

Jul 29, 2024 · 7 shares · 70 followers View post →
Otomo
@GravityParticle · X

ハルミンとエキセンディン-4の併用療法は、マウス異種移植システムにおいて、体内でヒトβ細胞量を安全に増加させる https://t.co/wiqAvgZSEV インスリン細胞を700%増加させる有望な糖尿病治療が病気を逆転させる希望をもたらす。 -糖尿病患者において内因性ベータ細胞を安全な方法で増殖実現すれば凄い

Jul 29, 2024 · 2 likes · 1,018 followers View post →
Dr. Pedro Luis -Longevidad
@DrPedroLuisGS · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/3RoTpOygvy

Jul 21, 2024 · 1,065 followers View post →
Alberto Bartolomé
@a_bartolome · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 19, 2024 · 13 shares · 129 followers View post →
Guy Rutter1
@guy_rutter · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 18, 2024 · 13 shares · 1,443 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/EBMIdPApXV

Jul 18, 2024 · 3,107 followers View post →
Sharon Baumel-Alterzon
@SAlterzon · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 18, 2024 · 13 shares · 584 followers View post →
David G. Armstrong follow @dgarmstrong.bsky.social
@DGArmstrong · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/4hBCnmfrHx https://t.co/M6DCxN7xfq

Jul 18, 2024 · 1 like · 11,916 followers View post →
Mitra_121
@121_mitra · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 18, 2024 · 10 shares · 1,949 followers View post →
Hassan Soltani
@Hassansoltani29 · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 16, 2024 · 10 shares · 852 followers View post →
Yaser
@yaser_m1900 · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 15, 2024 · 10 shares · 70 followers View post →
پلاک 100
@Suv850S · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 15, 2024 · 10 shares · 196 followers View post →
محسن
@Kf0exqZc7azuviP · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 15, 2024 · 10 shares · 30 followers View post →
poria
@poria_PNB · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 15, 2024 · 10 shares · 426 followers View post →
MPK50
@MehdiT60 · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 15, 2024 · 10 shares · 22 followers View post →
D M
@DavMo2020 · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 15, 2024 · 10 shares · 2,163 followers View post →
Cengiz
@Cengiz_AU · X

RT @erwinloh: #Diabetes-reversing drug boosts #insulin-producing cells by 700% Scientists have tested a new drug therapy in #diabetic mic…

Jul 15, 2024 · 1 share · 195 followers View post →
آمدنم بهر چه بود؟
@HaMohajer · X

RT @BlueJakk: داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷…

Jul 15, 2024 · 10 shares · 534 followers View post →
Blue Jack
@BlueJakk · X

داروی جدیدی ساخته شده که تونسته با کمک بازسازی سلولهای تولیدکننده #انسولین، ظرف ۳ ماه، تولید انسولین تو موشهای دیابتی را تا ۷۰۰ درصد افزایش بده! https://t.co/s4JhnDIaqF

Jul 15, 2024 · 605 likes · 10 shares · 46,811 followers View post →
Professor Erwin Loh
@erwinloh · X

#Diabetes-reversing drug boosts #insulin-producing cells by 700% Scientists have tested a new drug therapy in #diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease. https://t.co/F4E5O31cIa https://t.co/0fYnodD026

Jul 15, 2024 · 1 like · 1 share · 9,569 followers View post →
THERADELICS
@theradelics · X

Harmine and exendin-4 combination therapy safely expands human beta cell mass in vivo in a mouse xenograft system https://t.co/T4rOX8isUB https://t.co/mx7ETIRAmt

Jul 15, 2024 · 3,392 followers View post →
MARCELO MAIA PINHEIRO
@MARCELOMAIADr · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/KYeXUf8ST8

Jul 13, 2024 · 25 followers View post →
City of Hope Surgery
@CityofHopeSurg · X

RT @AGOcanaLab_COH: City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-produci…

Jul 12, 2024 · 5 shares · 987 followers View post →
profShonku
@daproteinator · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 12, 2024 · 13 shares · 61 followers View post →
Islet Biology Lab - UMH
@isletbiologylab · X

RT @AGOcanaLab_COH: City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-produci…

Jul 11, 2024 · 5 shares · 1,150 followers View post →
Geming (Brian) Lu
@Brian74534732 · X

RT @HayrTopcu: https://t.co/boj6cD56BM

Jul 11, 2024 · 1 share · 726 followers View post →
Geming (Brian) Lu
@Brian74534732 · X

RT @zenbrainest: Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science T…

Jul 11, 2024 · 1 share · 726 followers View post →
Geming (Brian) Lu
@Brian74534732 · X

RT @DanielJDrucker: Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function…

Jul 11, 2024 · 7 shares · 726 followers View post →
Hayrı Topcu
@HayrTopcu · X

https://t.co/boj6cD56BM

Jul 11, 2024 · 1 like · 1 share · 249 followers View post →
Esra Karaköse
@ekarakose · X

RT @AGOcanaLab_COH: City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-produci…

Jul 11, 2024 · 5 shares · 130 followers View post →
BryanRoth
@zenbrainest · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/JEPYSoHK7x

Jul 11, 2024 · 3 likes · 1 share · 17,004 followers View post →
Scott Soleimanpour
@SoleimanpourLab · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 11, 2024 · 13 shares · 1,741 followers View post →
Islet Biology Lab - UMH
@isletbiologylab · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 11, 2024 · 13 shares · 1,150 followers View post →
Diego Balboa
@_DiegoBalboa_ · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 11, 2024 · 13 shares · 1,229 followers View post →
Gavin Bewick
@GavBew · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 11, 2024 · 13 shares · 1,253 followers View post →
Geming (Brian) Lu
@Brian74534732 · X

RT @LickertHeiko: Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science…

Jul 10, 2024 · 3 shares · 726 followers View post →
Geming (Brian) Lu
@Brian74534732 · X

RT @randystyle: STM article from our lab is finally out!! https://t.co/qIwqvHif9u

Jul 10, 2024 · 1 share · 726 followers View post →
Matthew Merrins
@merrinslab · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 10, 2024 · 13 shares · 398 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @DanielJDrucker: Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function…

Jul 10, 2024 · 7 shares · 32,519 followers View post →
Dario F De Jesus
@DarioFDeJesus · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 10, 2024 · 13 shares · 445 followers View post →
Matthew Wortham
@WorthamLab · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 10, 2024 · 13 shares · 212 followers View post →
Neslihan Erdem
@erdem_nes · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 10, 2024 · 13 shares · 667 followers View post →
Waggoner Lab
@LabWaggoner · X

Harmine and exendin-4 (DYRK1A inhibitor–GLP1RA) combination therapy safely expands human β cell mass in vivo in a mouse xenograft system as an approach to diabetes treatment @ScienceTM https://t.co/vRnGxuswar https://t.co/qPblphHhxl

Jul 10, 2024 · 11,282 followers View post →
Randy Kang
@randystyle · X

STM article from our lab is finally out!! https://t.co/qIwqvHif9u

Jul 10, 2024 · 10 likes · 1 share · 73 followers View post →
Carolina Rosselot
@Carolinar353 · X

RT @AGOcanaLab_COH: City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-produci…

Jul 10, 2024 · 5 shares · 713 followers View post →
Geming (Brian) Lu
@Brian74534732 · X

RT @AGOcanaLab_COH: City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-produci…

Jul 10, 2024 · 5 shares · 726 followers View post →
Geming (Brian) Lu
@Brian74534732 · X

RT @AGOcanaLab_COH: Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely ex…

Jul 10, 2024 · 13 shares · 726 followers View post →
Adolfo Garcia Ocaña. Ph.D.
@AGOcanaLab_COH · X

City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-producing cells in vivo https://t.co/CiufdrsM07 The related work is published in Science Translational Medicine. https://t.co/TFLqLzEKYz

Jul 10, 2024 · 23 likes · 5 shares · 157 followers View post →
Shugo Sasaki
@shugosasaki · X

RT @LickertHeiko: Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science…

Jul 10, 2024 · 3 shares · 240 followers View post →
Adolfo Garcia Ocaña. Ph.D.
@AGOcanaLab_COH · X

Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system. https://t.co/TFLqLzEKYz

Jul 10, 2024 · 40 likes · 13 shares · 157 followers View post →
Diana
@PharmphoodTM · X

RT @DanielJDrucker: Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function…

Jul 10, 2024 · 7 shares · 557 followers View post →
Seigo Izumo
@SeigoIzumo · X

RT @DanielJDrucker: Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function…

Jul 10, 2024 · 7 shares · 3,968 followers View post →
nike
@wot_mikey · X

RT @LickertHeiko: Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science…

Jul 10, 2024 · 3 shares · 464 followers View post →
Ranganath Muniyappa
@dr_muniyappa · X

RT @DanielJDrucker: Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function…

Jul 10, 2024 · 7 shares · 1,090 followers View post →
Alberto Bartolomé
@a_bartolome · X

RT @DanielJDrucker: Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function…

Jul 10, 2024 · 7 shares · 129 followers View post →
Heiko Lickert
@LickertHeiko · X

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system | Science Translational Medicine https://t.co/U1bf2huLJQ

Jul 10, 2024 · 24 likes · 3 shares · 3,048 followers View post →
Daniel J Drucker
@DanielJDrucker · X

Advances in expanding human beta cell mass #diabetes Harmine + Exendin-4 promote altered β cell proliferation, function, and survival #islets @ScienceTM https://t.co/bKT5PfmCT7

Jul 10, 2024 · 18 likes · 7 shares · 34,083 followers View post →