Publications by authors named "Geoffrey Ku"

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A First-in-Human Study of Givastomig, a CLDN18.2 and 4-1BB Bispecific Antibody, as Monotherapy in Patients with CLDN18.2-Positive Advanced or Metastatic Solid Tumors.
Geoffrey Ku, Lin Shen, Farshid Dayyani, Jeremy Kratz, Xinjun Liang, Jou-Ku Chung

Clin Cancer Res· December 2025

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Characterization of the Safety Profile of Trastuzumab Deruxtecan by Dose: A Pooled Analysis Across DESTINY Studies.
Yeon Hee Park, Javier Cortes, Shanu Modi, Sara A Hurvitz, Giampaolo Bianchini, Geoffrey Y Ku, Nataliya Kuptsova-Clarkson

Oncologist· December 2025

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Genomic and clinical parallels between US and Japanese gastric cancers: a propensity score-matched cohort study.
Masaya Nakauchi, Colin Court, Henry S Walch, Miseker Abate, Shoji Shimada, Geoffrey Y Ku

Br J Surg· November 2025

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Intraperitoneal CAR T-cell therapy for peritoneal carcinomatosis from gastroesophageal cancer: preclinical investigations to a phase I clinical trial (NCT06623396).
David Restle, Alfredo Amador-Molina, Kyohei Misawa, Srijita Banerjee, Geoffrey Ku

J Immunother Cancer· September 2025

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Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study.
Kohei Shitara, Sylvie Lorenzen, Jin Li, Yuxian Bai, Manuel González Fernández, Geoffrey Ku, Shu-Kui Qin

J Clin Oncol· August 2025

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Esophagectomy may have a role in stage IV esophageal adenocarcinoma.
Marisa Sewell, Nicolas Toumbacaris, Kay See Tan, Nadia Bahadur, John Philip, Geoffrey Y Ku

J Thorac Cardiovasc Surg· July 2025

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Zanidatamab plus chemotherapy as first-line treatment for patients with HER2-positive advanced gastro-oesophageal adenocarcinoma: primary results of a multicentre, single-arm, phase 2 study.
Elena Elimova, Jaffer Ajani, Howard Burris, Crystal S Denlinger, Syma Iqbal, Geoffrey Ku

Lancet Oncol· July 2025

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Nonoperative Management of Mismatch Repair-Deficient Tumors.
Andrea Cercek, Michael B Foote, Benoit Rousseau, J Joshua Smith, Jinru Shia, Miteshkumar Patel, Geoffrey Ku

N Engl J Med· June 2025

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Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer.
Henry S Walch, Raktim Borpatragohain, Justin Jee, Waleed Chatila, Christopher Fong, Geoffrey Y Ku

Clin Cancer Res· May 2025

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A First-in-Human Study of Cinrebafusp Alfa, a HER2/4-1BB Bispecific Molecule, in Patients with HER2-Positive Advanced Solid Malignancies.
Sarina Piha-Paul, Shane A Olwill, Erika Hamilton, Anthony Tolcher, Paula Pohlmann, Raman Kumar, Markus Zettl, Geoffrey Ku

Clin Cancer Res· January 2025

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The efficacy of plasma exosomal miRNAs as predictive biomarkers for PD-1 blockade plus chemotherapy in gastric cancer.
Yunqi Hua, Shuang Luo, Qian Li, Ge Song, Xiaoling Tian, Geoffrey Ku

Transl Cancer Res· November 2024

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State of the art and upcoming trends in HER2-directed therapies in gastrointestinal malignancies.
Jaeyop Lee, Geoffrey Ku

Curr Opin Oncol· July 2024

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Advances in Human Epidermal Growth Factor Receptor 2-Targeted Therapy in Upper Gastrointestinal Cancers.
Jaeyop Lee, Geoffrey Ku

Hematol Oncol Clin North Am· June 2024

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Patient metabolic profile defined by liver and muscle F-FDG PET avidity is independently associated with overall survival in gastric cancer.
Gerardo A Vitiello, Vetri Sudar Jayaprakasam, Laura H Tang, Mark A Schattner, Yelena Y Janjigian, Geoffrey Y Ku

Gastric Cancer· May 2024

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F-BMS-986229 PET to Assess Programmed-Death Ligand 1 Status in Gastroesophageal Cancer.
Samuel L Cytryn, Neeta Pandit-Taskar, Melissa A Lumish, Steven B Maron, Ping Gu, Geoffrey Y Ku

J Nucl Med· May 2024

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Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer.
Melissa A Lumish, Henry Walch, Steven B Maron, Walid Chatila, Yelena Kemel, Geoffrey Y Ku

J Natl Cancer Inst· February 2024

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The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction.
Stephanie G Worrell, Karyn A Goodman, Nasser K Altorki, Jonathan B Ashman, Traves D Crabtree, Geoffrey Y Ku

Pract Radiat Oncol· January 2024

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The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction.
Stephanie G Worrell, Karyn A Goodman, Nasser K Altorki, Jonathan B Ashman, Traves D Crabtree, Geoffrey Y Ku

Ann Thorac Surg· January 2024

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Prognostic value of circumferential radial margin involvement in esophagectomy for esophageal cancer: a case series.
Thomas Boerner, Rebecca Carr, Meier Hsu, Kay See Tan, Carlie Sigel, Geoffrey Y Ku

Int J Surg· November 2023

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Unique Genomic Alterations and Microbial Profiles Identified in Patients With Gastric Cancer of African, European, and Asian Ancestry: A Novel Path for Precision Oncology.
Miseker Abate, Henry Walch, Kanika Arora, Chad M Vanderbilt, Teng Fei, Geoffrey Y Ku

Ann Surg· October 2023

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First-line regorafenib with nivolumab and chemotherapy in advanced oesophageal, gastric, or gastro-oesophageal junction cancer in the USA: a single-arm, single-centre, phase 2 trial.
Samuel L Cytryn, Ryan H Moy, Darren Cowzer, Ronak H Shah, Joanne F Chou, Geoffrey Y Ku

Lancet Oncol· October 2023

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Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer.
Steven B Maron, Walid Chatila, Henry Walch, Joanne F Chou, Nicholas Ceglia, Geoffrey Yuyat Ku

Clin Cancer Res· September 2023

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Trastuzumab deruxtecan in patients in the USA and Europe with HER2-positive advanced gastric or gastroesophageal junction cancer with disease progression on or after a trastuzumab-containing regimen (DESTINY-Gastric02): primary and updated analyses from a single-arm, phase 2 study.
Eric Van Cutsem, Maria di Bartolomeo, Elizabeth Smyth, Ian Chau, Haeseong Park, Geoffrey Ku

Lancet Oncol· July 2023

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Perioperative versus total neoadjuvant chemotherapy in gastric cancer.
Jessica Yang, Megan Greally, Vivian E Strong, Daniel G Coit, Joanne F Chou, Geoffrey Y Ku

J Gastrointest Oncol· June 2023

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Clinical Utility of F-2-Fluoro-deoxy-d-glucose PET Imaging in Locally Advanced Esophageal/Gastroesophageal Junction Adenocarcinoma.
Darren Cowzer, Fergus Keane, Geoffrey Y Ku

Diagnostics (Basel)· May 2023

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